Cisplatin and bleomycin in the treatment of esophageal carcinoma. A final report.

abstract：BACKGROUND:The incidence of bronchioloalveolar carcinoma of the lung (BAC), a pathologically distinct type of nonsmall cell lung carcinoma (NSCLC), appears to be rising. In this study, the authors compared data on the clinical presentation and clinical courses of patients with Stage IIIB and IV BAC with data on other t...

journal_title：Cancer

authors： Breathnach OS,Ishibe N,Williams J,Linnoila RI,Caporaso N,Johnson BE

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients. METHODS:The authors reviewed the records of 124 patients > 1 year of age at diagnosis of International Neuroblas...

journal_title：Cancer

authors： McGregor LM,Rao BN,Davidoff AM,Billups CA,Hongeng S,Santana VM,Hill DA,Fuller C,Furman WL

更新日期：2005-12-15 00:00:00

abstract：BACKGROUND:National Cancer Institute of Canada Clinical Trials Group PA.3 (NCIC CTG PA.3) was a phase 3 study (n = 569) that demonstrated benefits for overall survival and progression-free survival with the addition of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib to gemcitabine ...

journal_title：Cancer

authors： da Cunha Santos G,Dhani N,Tu D,Chin K,Ludkovski O,Kamel-Reid S,Squire J,Parulekar W,Moore MJ,Tsao MS

更新日期：2010-12-15 00:00:00

abstract：BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...

journal_title：Cancer

authors： Suzuki M,Shigematsu H,Iizasa T,Hiroshima K,Nakatani Y,Minna JD,Gazdar AF,Fujisawa T

更新日期：2006-05-15 00:00:00

abstract：:The efficacy of mitoxantrone in combination with vinblastine was assessed in 156 patients with metastatic breast cancer who had been treated previously with one or multiple chemotherapeutic regimens. Mitoxantrone was given by random assignment, either as a 10 mg/m2 single intravenous dose or in five consecutive daily ...

journal_title：Cancer

authors： Fraschini G,Yap HY,Mann G,Buzdar AU,Blumenschein GR,Hortobagyi GN

更新日期：1987-10-15 00:00:00

abstract：:This report documents, in seven infants younger than 2 years of age, a previously unrecognized association of a renal embryonal neoplasm (malignant rhabdoid tumor in six patients and a Wilms' tumor in one) with an embryonal primary tumor originating in the central nervous system. The neuroepithelial tumors included th...

journal_title：Cancer

authors： Bonnin JM,Rubinstein LJ,Palmer NF,Beckwith JB

更新日期：1984-11-15 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia (CML) can be treated effectively with tyrosine kinase inhibitor therapy directed at BCR-ABL, but access to care, medication cost, and adherence may be barriers to treatment. This study was designed to determine whether the insurance status at diagnosis influences CML patient outcomes...

journal_title：Cancer

authors： Perry AM,Brunner AM,Zou T,McGregor KL,Amrein PC,Hobbs GS,Ballen KK,Neuberg DS,Fathi AT

更新日期：2017-07-01 00:00:00

abstract：:One hundred and sixty-two cases of Stage IA microinvasive carcinoma of the cervix are presented. These patients represent the combined experience at the University of Miami School of Medicine, Miami, Florida, and Downstate Medical Center, Brooklyn, New York. The criteria used in both institutions are 1) penetration of...

journal_title：Cancer

authors： Averette HE,Nelson JH Jr,Ng AB,Hoskins WJ,Boyce JG,Ford JH Jr

更新日期：1976-07-01 00:00:00

abstract：:Interleukin (IL)-2 therapy leads to respiratory dysfunction due to increased vascular permeability. This study examines the role of the chemoattractant, immunomodulator, and permeability-promoting agent leukotriene (LT) B4 in this setting. Sheep with chronic lung lymph fistulae were given IL-2, 10(5) U/kg as an IV bol...

journal_title：Cancer

authors： Klausner JM,Goldman G,Skornick Y,Valeri R,Inbar M,Shepro D,Hechtman HB

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Between 1980-1990, 126 patients were treated with radiation therapy (RT) and hyperthermia using 915-MHz external microwave applicators. All but 11 patients had failed to respond to previous therapy. METHODS:The mean tumor volume was 73 +/- 13 cm3, and the mean radiation dose delivered was 45 +/- 1 Gy. Hyper...

journal_title：Cancer

authors： Engin K,Leeper DB,Tupchong L,Waterman FM,Mansfield CM

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is dysregulated in patients with metastatic renal cell carcinoma (mRCC). Buparlisib is a pan-PI3K inhibitor with activity in advanced solid tumors. The primary objective of the current study was to determine the maximum...

journal_title：Cancer

authors： McKay RR,De Velasco G,Werner L,Bellmunt J,Harshman L,Sweeney C,Rosenberg JE,Hirsch M,Signoretti S,Van Allen EM,Walsh M,Vaishampayan U,McDermott DF,Choueiri TK

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Patients with invasive breast carcinoma who are ages 35-40 years or younger at the time of diagnosis have been found in several studies to have worse prognosis and higher local failure rates after breast-conserving therapy (BCT) compared with older patients. However, it is uncertain whether specific clinical...

journal_title：Cancer

authors： Zhou P,Recht A

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:Axillary reverse mapping (ARM) is a novel technique to preserve upper extremity lymphatics that may reduce the incidence of lymphedema after axillary lymph node dissection. Early reports have suggested that ARM lymph nodes do not contain metastatic disease from breast cancer; however, these studies were cond...

journal_title：Cancer

authors： Bedrosian I,Babiera GV,Mittendorf EA,Kuerer HM,Pantoja L,Hunt KK,Krishnamurthy S,Meric-Bernstam F

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Reports on lymphoid malignancy and its treatment in children infected with human immunodeficiency virus (HIV) are limited. METHODS:Antibodies to Epstein-Barr virus (EBV) were detected by indirect immunofluorescence. DNA was extracted from peripheral blood lymphocytes or biopsy specimens. Polymerase chain re...

journal_title：Cancer

authors： Nadal D,Caduff R,Frey E,Hassam S,Zimmermann DR,Seigneurin JM,Plüss HJ,Seger RA

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Treatment of febrile neutropenia (FN) is costly, because it typically involves hospitalization. As cancer rates continue to increase, the number of patients suffering from FN will also increase, making it important to quantify the costs of treating this condition accurately and comprehensively. METHODS:A co...

journal_title：Cancer

authors： Lathia N,Mittmann N,DeAngelis C,Knowles S,Cheung M,Piliotis E,Shear N,Walker S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The optimal use of radiation therapy for cancer treatment is hampered by the application of tolerance limits of normal tissues derived empirically from population averages. Such limits do not reflect the considerable differences from patient to patient in susceptibility to late radiation sequelae. Assays tha...

journal_title：Cancer

authors： Peters LJ

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Chemotherapy improves survival for patients with stage III colon cancer, but some older patients with lymph node-positive colon cancer do not see a medical oncologist and, thus, do not receive adjuvant chemotherapy. METHODS:To evaluate the role of the surgeon in determining referrals to medical oncology amo...

journal_title：Cancer

authors： Luo R,Giordano SH,Zhang DD,Freeman J,Goodwin JS

更新日期：2007-03-01 00:00:00

abstract：:A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer t...

journal_title：Cancer

authors： Black MM,Zachrau RE,Shore B,Moore DH,Leis HP Jr

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...

journal_title：Cancer

authors： Hillner BE,Radice D

更新日期：2001-02-01 00:00:00

abstract：:The urinary neopterin excretion was measured by high-performance liquid chromatography in 417 healthy subjects and in 76 patients with clinically and pathohistologically verified neoplasias of the urinary tract (bladder tumor, carcinoma of the prostate, and renal cell carcinoma). The patients with early tumor stages b...

journal_title：Cancer

authors： Aulitzky W,Frick J,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Cetuximab in combination with docetaxel was examined in chemotherapy-refractory/resistant patients with advanced nonsmall-cell lung cancer (NSCLC) to determine response rate, survival, safety, and pharmacokinetics (PK). METHODS:Patients had evidence of epidermal growth factor receptor (EGFR) expression (> o...

journal_title：Cancer

authors： Kim ES,Mauer AM,William WN Jr,Tran HT,Liu D,Lee JJ,Windt P,Hong WK,Vokes EE,Herbst RS

更新日期：2009-04-15 00:00:00

abstract：:The authors describe the results of a hospital-based incident case-control study of lung cancer conducted in a high-risk region of southern Louisiana from January 1979 through April 1982. Dietary intake of carotene, retinol, and vitamin C was estimated from food frequency questionnaires administered to 1253 cases and ...

journal_title：Cancer

authors： Fontham ET,Pickle LW,Haenszel W,Correa P,Lin YP,Falk RT

更新日期：1988-11-15 00:00:00

abstract：:Fourteen examples of intravenous leiomyomatosis in the FIP files were studied. Growth beyond the uterus occurred in 10 of the 14 examples, largely in vessels in the broad ligament and in uterine and iliac veins. Metastasis to the heart occurred in 1 example. The study provides evidence that is consistent with both the...

journal_title：Cancer

authors： Norris HJ,Parmley T

更新日期：1975-12-01 00:00:00

abstract：:A 21-year-old patient, after radiation therapy to the mediastinum for Hodgkin's disease, died six years later of a spinal cord glioma, believed to be caused by irradiation therapy. That the x-ray therapy provoked neoplastic changes seems likely, although it could be coincidental. ...

journal_title：Cancer

authors： Clifton MD,Amromin GD,Perry MC,Abadir R,Watts C,Levy N

更新日期：1980-04-15 00:00:00

abstract：BACKGROUND:Validation of the prognostic indices for the recurrence-free interval of patients with parotid carcinoma, the development of which was described in a previous report, is needed to be confident of their generalizability and justified prospective use. METHODS:The Dutch Cooperative Group on Head and Neck Cance...

journal_title：Cancer

authors： Vander Poorten VL,Hart AA,van der Laan BF,Baatenburg de Jong RJ,Manni JJ,Marres HA,Meeuwis CA,Lubsen H,Terhaard CH,Balm AJ

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:Ultrasound (US) is more sensitive than physical examination alone in determining axillary lymph node involvement during preliminary staging of breast carcinoma. Due to occasional overlap of sonographic features of benign and indeterminate lymph nodes, fine-needle aspiration (FNA) of sonographically indetermi...

journal_title：Cancer

authors： Krishnamurthy S,Sneige N,Bedi DG,Edieken BS,Fornage BD,Kuerer HM,Singletary SE,Hunt KK

更新日期：2002-09-01 00:00:00

abstract：:Seventeen patients with primary or secondary liver tumors were treated by dearterialization of the liver and intraportal infusion of cytotoxic drugs. In 14 cases, ligation of the main (10), right and left (1), right and middle (1), and right (2) hepatic arteries was performed. In three in whom hepatic artery ligation ...

journal_title：Cancer

authors： Nagasue N,Inokuchi K,Kobayashi M,Ogawa Y,Iwaki A

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Hypoxia inducible factor-1 (HIF-1) plays a critical role in angiogenesis during vascular development. The authors tested the hypothesis that HIF-1 expression correlates with progression and angiogenesis in brain tumors. METHODS:The authors investigated the expression of the HIF-1alpha and HIF-1beta subunits...

journal_title：Cancer

authors： Zagzag D,Zhong H,Scalzitti JM,Laughner E,Simons JW,Semenza GL

更新日期：2000-06-01 00:00:00

abstract：:Despite relatively high response rates to chemotherapy for ovarian carcinoma, most patients eventually will have progressive disease that will require additional therapy. Most efforts to study such second-line or "salvage" chemotherapy have been single-arm trials of small numbers of patients, which report widely varia...

journal_title：Cancer

authors： Thigpen JT,Vance RB,Khansur T

更新日期：1993-02-15 00:00:00

abstract：:A questionnaire evaluating attitudes towards cancer (the Cancer Attitudes Questionnaire) was constructed to compare the attitudes of first-year medical students before and after taking a clinical oncology program with those of students who did not participate in the program. A factor and reliability analysis revealed ...

journal_title：Cancer

authors： Lebovits AH,Croen LG,Goetzel RZ

更新日期：1984-09-15 00:00:00