Associations between smoking status and stage of colorectal cancer at diagnosis in Massachusetts between 1982 and 1987.


:To examine the relationship between smoking and stage of colorectal cancer at diagnosis, data on 2788 current smokers and 6313 nonsmokers with known stage at diagnosis were obtained from the Massachusetts Cancer Registry. The stage at diagnosis was treated as a polytomous response variable in a logit-type, log-linear (Poisson) model, with smoking status, age, sex, and race as covariates. The relative frequency of disseminated colorectal cancer was 45% greater in smokers, compared with nonsmokers (relative risk [RR] = 1.45; 95% confidence interval, 1.00 to 2.09). A substudy was conducted to determine the accuracy of the registry's smoking data; the findings suggest that the actual association may be larger than that presented above. These results confirm the presence of an association between smoking and advanced stage of colorectal cancer at diagnosis. Whether the association is due to a biologic or behavioral phenomenon cannot be determined from these data.






Longnecker MP,Clapp RW,Sheahan K




Has Abstract


1989-09-15 00:00:00














  • Malignant thymoma with peripheral blood lymphocytosis.

    abstract::A 37-year-old woman with a giant, lymphocytic predominant thymoma involving the pleura and accompanied by a sharp peripheral blood lymphocytosis is described. Only electromicroscopic and immunohistologic studies could exclude the alternative diagnosis of mediastinal lymphoma. The tumor and peripheral blood lymphocytes...


    pub_type: 杂志文章


    authors: Shachor Y,Radnay J,Bernheim J,Rozenszajn A,Bruderman I,Klajman A,Steiner ZP

    更新日期:1988-03-15 00:00:00

  • Assessment of quality of survival in children with medulloblastoma and cerebellar astrocytoma.

    abstract::To determine the quality of survival for children with posterior fossa tumors, comprehensive neuropsychological, behavioral, and academic assessment and physician ratings of functional status were obtained on 15 brain tumor patients (ages 6-19 years) at a median of 20 months post-diagnosis. More than 50% of the childr...


    pub_type: 杂志文章


    authors: LeBaron S,Zeltzer PM,Zeltzer LK,Scott SE,Marlin AE

    更新日期:1988-09-15 00:00:00

  • State-of-the-science of patient navigation as a strategy for enhancing minority clinical trial accrual.

    abstract:BACKGROUND:Patient navigation programs are emerging that aim to address disparities in clinical trial participation among medically underserved populations, including racial/ethnic minorities. However, there is a lack of consensus on the role of patient navigators within the clinical trial process as well as outcome me...


    pub_type: 杂志文章,评审


    authors: Ghebre RG,Jones LA,Wenzel JA,Martin MY,Durant RW,Ford JG

    更新日期:2014-04-01 00:00:00

  • Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.

    abstract::Eighty-one primary ovarian carcinoids and intraovarian metastases from six mid-gut carcinoids were examined for the presence of tumor cells immunoreactive with antisera raised against various neurohormonal peptides, mostly of gastroenteropancreatic (GEP) origin. Twenty of the primary and two of the metastatic carcinoi...


    pub_type: 杂志文章


    authors: Sporrong B,Falkmer S,Robboy SJ,Alumets J,Håkanson R,Ljungberg O,Sundler F

    更新日期:1982-01-01 00:00:00

  • Endoscopic ultrasound-guided fine-needle aspiration biopsy of the adrenal glands: analysis of 24 patients.

    abstract:BACKGROUND:Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy allows the detailed imaging and FNA not only of both intramural and extramural structures and lesions of the gastrointestinal (GI) tract but also of various intraabdominal organs. Thus, EUS-FNA biopsy offers a novel opportunity to evaluate ...


    pub_type: 杂志文章


    authors: Jhala NC,Jhala D,Eloubeidi MA,Chhieng DC,Crowe DR,Roberson J,Eltoum I

    更新日期:2004-10-25 00:00:00

  • DNA ploidy of ovarian granulosa cell tumors. Lack of correlation between DNA index or proliferative index and outcome in 40 patients.

    abstract:BACKGROUND:Most cases of granulosa cell tumor of the ovary are characterized by relatively good outcome; however, some tumors behave aggressively, and some tend to recur many years after the initial diagnosis. Because DNA ploidy has been shown to predict biologic behavior better than conventional prognostic variables i...


    pub_type: 杂志文章


    authors: Evans MP,Webb MJ,Gaffey TA,Katzmann JA,Suman VJ,Hu TC

    更新日期:1995-05-01 00:00:00

  • The effects of radiotherapy on immunity in patients with cured localized carcinoma of the cervix uteri.

    abstract::The effects of radiotherapy on immune status in patients with localized carcinoma of the cervix have been assessed serially up to 5 years remission by a wide range of methods. Neutrophil function and serum immunoglobulins were essentially normal throughout. Peripheral blood neutrophil and lymphocyte counts and the pro...


    pub_type: 杂志文章


    authors: Hancock BW,Bruce L,Whitham MD,Ward AM

    更新日期:1984-02-15 00:00:00

  • Alternative bimonthly cycles of doxorubicin, cyclophosphamide, and etoposide, cisplatin with hematopoietic growth factor support in patients with carcinoma of unknown primary site.

    abstract:BACKGROUND:Because carcinomas of unknown primary origin are highly malignant tumors with a bad prognosis (median survival, 6-12 months) and no current optimal therapy, the authors designed a prospective dose-dense chemotherapy regimen with the objective of improving the results observed in patients who receive conventi...


    pub_type: 临床试验,杂志文章


    authors: Culine S,Fabbro M,Ychou M,Romieu G,Cupissol D,Pinguet F

    更新日期:2002-02-01 00:00:00

  • Oxaliplatin and capecitabine in the treatment of patients with recurrent or refractory carcinoma of unknown primary site: a phase 2 trial of the Sarah Cannon Oncology Research Consortium.

    abstract:BACKGROUND:Despite the widespread use of oxaliplatin-based regimens for colorectal and other gastrointestinal cancers, there is surprisingly little information regarding their empiric use for the treatment of carcinoma of unknown primary site (CUP). In the current study, the combination of oxaliplatin and capecitabine ...


    pub_type: 杂志文章,多中心研究


    authors: Hainsworth JD,Spigel DR,Burris HA 3rd,Shipley D,Farley C,Macias-Perez IM,Barton J,Greco FA

    更新日期:2010-05-15 00:00:00

  • Symptomatic mucocutaneous toxicity of hydroxyurea in Philadelphia chromosome-negative myeloproliferative neoplasms: the Mister Hyde face of a safe drug.

    abstract:BACKGROUND:The current study was conducted to evaluate severe mucocutaneous toxicity during treatment with hydroxyurea (HU) in a large cohort of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). METHODS:Among 993 consecutive patients newly diagnosed with MPN at 4 centers in Rome betwee...


    pub_type: 杂志文章


    authors: Latagliata R,Spadea A,Cedrone M,Di Giandomenico J,De Muro M,Villivà N,Breccia M,Anaclerico B,Porrini R,Spirito F,Rago A,Avvisati G,Alimena G,Montanaro M,Andriani A,Gruppo Laziale SMPC Ph1 neg.

    更新日期:2012-01-15 00:00:00

  • Meaningful endpoints for therapies approved for hematologic malignancies.

    abstract:BACKGROUND:Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new...


    pub_type: 杂志文章


    authors: Smith BD,DeZern AE,Bastian AW,Durie BGM

    更新日期:2017-05-15 00:00:00

  • A new method for analyzing the cell kinetics of human brain tumors by double labeling with bromodeoxyuridine in situ and with iododeoxyuridine in vitro.

    abstract:BACKGROUND:Cell kinetics studies performed with immunohistochemical techniques to estimate the S-phase fraction have elucidated the proliferative potential of individual brain tumors. METHODS:The authors developed a new double-labeling method that enables other cell kinetics variables, including the duration of the S-...


    pub_type: 杂志文章


    authors: Shibuya M,Ito S,Davis RL,Wilson CB,Hoshino T

    更新日期:1993-05-15 00:00:00

  • Comparison of two total body irradiation fractionation regimens with respect to acute and late pulmonary toxicity.

    abstract:BACKGROUND:Total body irradiation (TBI) is commonly used with autologous bone marrow transplantation (BMT) for treatment of hematologic malignancies. Pulmonary complications of TBI can cause long-term morbidity and mortality. The authors have compared the pulmonary toxicity and efficacy of two different TBI fractionati...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gopal R,Ha CS,Tucker SL,Khouri IF,Giralt SA,Gajewski JL,Andersson BS,Cox JD,Champlin RE

    更新日期:2001-10-01 00:00:00

  • Underestimation of malignancy of breast core-needle biopsy: concepts and precise overall and category-specific estimates.

    abstract:BACKGROUND:A review of the literature indicated variable underestimation rates for breast core-needle biopsy (CNB) based on generally small series. In this article, the authors present precise estimates for overall underestimation and for categories of histologic underestimates (including categories that reflect contem...


    pub_type: 杂志文章,meta分析


    authors: Houssami N,Ciatto S,Ellis I,Ambrogetti D

    更新日期:2007-02-01 00:00:00

  • Idiopathic giant cell myocarditis after autologous hematopoietic stem cell transplantation and interleukin-2 immunotherapy: a case report.

    abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...


    pub_type: 杂志文章


    authors: Truica CI,Hansen CH,Garvin DF,Meehan KR

    更新日期:1998-09-15 00:00:00

  • Imaging-based biomarkers: Changes in the tumor interface of pancreatic ductal adenocarcinoma on computed tomography scans indicate response to cytotoxic therapy.

    abstract:BACKGROUND:The assessment of pancreatic ductal adenocarcinoma (PDAC) response to therapy remains challenging. The objective of this study was to investigate whether changes in the tumor/parenchyma interface are associated with response. METHODS:Computed tomography (CT) scans before and after therapy were reviewed in 4...


    pub_type: 杂志文章


    authors: Amer AM,Zaid M,Chaudhury B,Elganainy D,Lee Y,Wilke CT,Cloyd J,Wang H,Maitra A,Wolff RA,Varadhachary G,Overman MJ,Lee JE,Fleming JB,Tzeng CW,Katz MH,Holliday EB,Krishnan S,Minsky BD,Herman JM,Taniguchi CM,Das P,

    更新日期:2018-04-15 00:00:00

  • Evaluation of fluorescence polarization of human blood lymphocytes (SCM test) in the diagnosis of cancer.

    abstract::Fluorescence polarization was performed on 82 individuals: 32 patients with malignant diseases, 30 apparently healthy individuals, and 20 patients with nonmalignant diseases. The blood lymphocytes from these cases were isolated and challenged with cancer basic protein (CaBP). Stimulation occurred in the majority of th...


    pub_type: 杂志文章


    authors: Schnuda ND

    更新日期:1980-09-01 00:00:00

  • Racial disparities in postmastectomy breast reconstruction: National trends in utilization from 2005 to 2014.

    abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...


    pub_type: 杂志文章


    authors: Epstein S,Tran BN,Cohen JB,Lin SJ,Singhal D,Lee BT

    更新日期:2018-07-01 00:00:00

  • Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction. A proposed classification of DNA histograms in breast cancer.

    abstract::To optimize the prognostic value of DNA flow cytometry in breast cancer the authors calculated several parameters from the DNA histogram, including the DNA index, the size and number of aneuploid peaks as well as S-phase and G2/M-phase cell cycle fractions. Of these, DNA index and S-phase fraction (SPF) proved to be t...


    pub_type: 杂志文章


    authors: Kallioniemi OP,Blanco G,Alavaikko M,Hietanen T,Mattila J,Lauslahti K,Lehtinen M,Koivula T

    更新日期:1988-11-15 00:00:00

  • Early referral to supportive care specialists for symptom burden in lung cancer patients: a comparison of non-Hispanic whites, Hispanics, and non-Hispanic blacks.

    abstract:BACKGROUND:Effective management of symptoms in cancer patients requires early intervention. This study assessed whether the timing of referral to the Supportive Care Center (SCC) and symptom burden outcome varied by race or ethnicity in lung cancer patients who had been seen at a tertiary cancer center. METHODS:Non-Hi...


    pub_type: 杂志文章


    authors: Reyes-Gibby CC,Anderson KO,Shete S,Bruera E,Yennurajalingam S

    更新日期:2012-02-01 00:00:00

  • Intracystic papillary carcinoma: a review of 917 cases.

    abstract:BACKGROUND:Intracystic papillary carcinoma (IPC) is an uncommon breast neoplasm. To the authors' knowledge there are limited data regarding its epidemiology and only small studies focusing on outcomes. By using a large, population-based database, this study aimed to identify specific characteristics of patients with IP...


    pub_type: 杂志文章


    authors: Grabowski J,Salzstein SL,Sadler GR,Blair S

    更新日期:2008-09-01 00:00:00

  • The immunochemical complexity of CEA: a golden dream or molecular nightmare?

    abstract::Carcinoembryonic antigen is only a tumor assoicated antigen and is less clinically useful than the original report suggested. However, the CEA assays in clinical use utilize reagents operationally defined by old criteria. There is now abundant evidence that "CEA" consists of a heterogenous family of related glycoprote...


    pub_type: 杂志文章


    authors: Alpert E

    更新日期:1978-09-01 00:00:00

  • Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer.

    abstract:BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...


    pub_type: 杂志文章


    authors: Suzuki M,Shigematsu H,Iizasa T,Hiroshima K,Nakatani Y,Minna JD,Gazdar AF,Fujisawa T

    更新日期:2006-05-15 00:00:00

  • Multivariate analysis for histologic prognostic factors in soft tissue sarcomas.

    abstract::To investigate histologic prognostic factors in soft tissue sarcomas (STS), multivariate analysis was performed on 236 patients with complete clinical information. These included 141 males and 95 females with an age range from 1 to 85 years (median, 47.6 years). Histologically, malignant fibrous histiocytoma (33.5%) w...


    pub_type: 杂志文章


    authors: Tsujimoto M,Aozasa K,Ueda T,Morimura Y,Komatsubara Y,Doi T

    更新日期:1988-09-01 00:00:00

  • Fine-needle aspiration biopsy of granulocytic sarcoma: a clinicopathologic study of 27 cases.

    abstract:BACKGROUND:Because of morphologic similarities, the differential diagnosis of granulocytic sarcoma (GS) in fine-needle aspiration (FNA) specimens includes non-Hodgkin or Hodgkin lymphoma, extramedullary hematopoiesis, poorly differentiated carcinoma, and infection. METHODS:Twenty-six FNAs and 1 pleural effusion fluid ...


    pub_type: 杂志文章


    authors: Suh YK,Shin HJ

    更新日期:2000-12-25 00:00:00

  • Evaluation of a protective environment in the management of granulocytopenic patients: a comparative study.

    abstract::Fever, clinical infection, bacteriologically documented infection, and death from infection were evaluated in 95 consecutive uninfected patients with severe granulocytopenia (less than 0.5 x 10(6)/liter). Patients were randomly allocated to reverse isolation and prophylactic oral nonabsorbable antibiotics or to open w...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ribas-Mundo M,Granena A,Rozman C

    更新日期:1981-07-15 00:00:00

  • Risk of mortality in patients with cancer who experience febrile neutropenia.

    abstract:BACKGROUND:Febrile neutropenia (FN) is a serious and potentially life-threatening condition that may develop in patients with cancer who receive myelosuppressive chemotherapy. The risk of mortality from FN is not well characterized in current clinical practice. METHODS:Patients with cancer who were receiving chemother...


    pub_type: 杂志文章


    authors: Lyman GH,Michels SL,Reynolds MW,Barron R,Tomic KS,Yu J

    更新日期:2010-12-01 00:00:00

  • Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential.

    abstract::Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive pot...


    pub_type: 杂志文章,评审


    authors: Varughese RS,Lam WS,Marican AABH,Viganeshwari SH,Bhave AS,Syn NL,Wang J,Wong AL,Kumar AP,Lobie PE,Lee SC,Sethi G,Goh BC,Wang L

    更新日期:2019-06-01 00:00:00

  • Preliminary results of aggressive multimodality therapy for metastatic osteosarcoma.

    abstract::Ten patients with metastatic osteosarcoma were treated at the Joint Center for Radiation Therapy, the Sidney Farber Cancer Institute, and the Children's Hospital Medical Center from 1973 to 1976. Patients were treated with an aggressive multimodality approach with included surgery, chemotherapy, and radiation therapy....


    pub_type: 杂志文章


    authors: Weichselbaum RR,Cassady JR,Jaffe N,Filler RM

    更新日期:1977-07-01 00:00:00

  • Inhibition of radiogenic mammary carcinoma in rats by estriol or tamoxifen.

    abstract::Mammary carcinomas have been induced by 3.5 Gy whole-body gamma radiation administered at age 40 to 50 days to virgin female Sprague-Dawley rats. In 142 irradiated controls carcinoma incidence averaged 7.8% in survivors observed less than 300 days and 38.3% of those surviving longer (P less than 0.001 by t test). Mamm...


    pub_type: 杂志文章


    authors: Lemon HM,Kumar PF,Peterson C,Rodriguez-Sierra JF,Abbo KM

    更新日期:1989-05-01 00:00:00