Abstract:
:To examine the relationship between smoking and stage of colorectal cancer at diagnosis, data on 2788 current smokers and 6313 nonsmokers with known stage at diagnosis were obtained from the Massachusetts Cancer Registry. The stage at diagnosis was treated as a polytomous response variable in a logit-type, log-linear (Poisson) model, with smoking status, age, sex, and race as covariates. The relative frequency of disseminated colorectal cancer was 45% greater in smokers, compared with nonsmokers (relative risk [RR] = 1.45; 95% confidence interval, 1.00 to 2.09). A substudy was conducted to determine the accuracy of the registry's smoking data; the findings suggest that the actual association may be larger than that presented above. These results confirm the presence of an association between smoking and advanced stage of colorectal cancer at diagnosis. Whether the association is due to a biologic or behavioral phenomenon cannot be determined from these data.
journal_name
Cancerjournal_title
Cancerauthors
Longnecker MP,Clapp RW,Sheahan Kdoi
10.1002/1097-0142(19890915)64:6<1372::aid-cncr2820subject
Has Abstractpub_date
1989-09-15 00:00:00pages
1372-4issue
6eissn
0008-543Xissn
1097-0142journal_volume
64pub_type
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