Abstract:
BACKGROUND:Ordinary craniopharyngiomas affecting sellar regions of children and preadolescents are composed of ameloblastomatous and/or squamous constituents. The authors encountered an autopsy case of a stillborn infant with a large craniopharyngioma with unusual manifestations. METHODS:The craniopharyngioma was analyzed using detailed histologic and immunohistochemical techniques. RESULTS:An autopsy revealed a large tumor arising from the pituitary gland with associated severe hydrocephalus. Histologically, the cells of the tumor showed features of ameloblastoma and organoid structures simulating tooth buds and adenohypophyseal primordia in the stage of organogenesis. Cells of the latter were shown to be immunoreactive for chromogranin A and six adenohypophyseal hormones. CONCLUSIONS:Because embryology of the adenohypophysis and the teeth indicated that all of the epithelia in this tumor emerged during the normal development of the stomodeum, it was believed that an "embryonal form of craniopharyngioma" would characterize this organoid neoplasm best. The possible morphogenesis of craniopharyngioma is also discussed.
journal_name
Cancerjournal_title
Cancerauthors
Yamada H,Haratake J,Narasaki T,Oda Tdoi
10.1002/1097-0142(19950615)75:12<2971::aid-cncr282subject
Has Abstractpub_date
1995-06-15 00:00:00pages
2971-7issue
12eissn
0008-543Xissn
1097-0142journal_volume
75pub_type
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