Abstract:
BACKGROUND:Multifocal tumor areas occurred in 12-22% of patients with renal cell carcinoma. It is unknown whether these tumors have malignant potential and characterize a higher risk for metastases. The performance of nephron-sparing surgery in patients with low grade or low stage tumors is controversial. METHODS:Primary and secondary tumors were analyzed by conventional cytogenetics and fluorescence in situ hybridization. Production of interleukin (IL)-6, IL-10, IL-11, and transforming growth factor (TGF)-beta1 were determined using standard enzyme-linked immunosorbent assay and bioassays. RESULTS:In 15.2% of the renal cell carcinoma cases evaluated, multifocal tumors were detected. Cytogenetics revealed a concordance of primary and secondary tumors in 9 of 14 cases (64%). In 11 of 12 multifocal tumors (94%), the same immunologic activity status was observed in both primary and secondary tumors. CONCLUSIONS:Secondary tumors must be expected to have malignant potential similar to that of the primary tumors. This was underscored by the high concordance of cytogenetic, histopathologic, and immunologic data in this study.
journal_name
Cancerjournal_title
Cancerauthors
Junker K,Schlichter A,Junker U,Knöfel B,Kosmehl H,Schubert J,Claussen Usubject
Has Abstractpub_date
1997-03-01 00:00:00pages
975-81issue
5eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19970301)79:5<975::AID-CNCjournal_volume
79pub_type
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