Abstract:
:Recent disease-oriented phase II clinical trials in advanced transitional cell carcinoma of the urothelial tract have defined the therapeutic efficacy of cis-diamminedichloride platinum II, Adriamycin and methotrexate. Other agents which may have some activity include cyclophosphamide, the podophyllotoxins, hexamethylmelamine, and possibly 5-flourouracil. While combination drug regimens have been reported to induce higher remission rates when compared to single agents, prospective randomized trials will be needed to document enhanced therapeutic benefit. The problems in selecting appropriate patients and in defining response criteria in clinical trials in urothelial tumors are discussed. Chemotherapy data in the treatment of bladder cancer is summarized, using strict response criteria.
journal_name
Cancerjournal_title
Cancerauthors
Yagoda Adoi
10.1002/cncr.1980.45.s7.1879subject
Has Abstractpub_date
1980-04-01 00:00:00pages
1879-1888eissn
0008-543Xissn
1097-0142journal_volume
45 Suppl 7pub_type
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