Chemotherapy of Metastatic Bladder Cancer.

Abstract:

:Recent disease-oriented phase II clinical trials in advanced transitional cell carcinoma of the urothelial tract have defined the therapeutic efficacy of cis-diamminedichloride platinum II, Adriamycin and methotrexate. Other agents which may have some activity include cyclophosphamide, the podophyllotoxins, hexamethylmelamine, and possibly 5-flourouracil. While combination drug regimens have been reported to induce higher remission rates when compared to single agents, prospective randomized trials will be needed to document enhanced therapeutic benefit. The problems in selecting appropriate patients and in defining response criteria in clinical trials in urothelial tumors are discussed. Chemotherapy data in the treatment of bladder cancer is summarized, using strict response criteria.

journal_name

Cancer

journal_title

Cancer

authors

Yagoda A

doi

10.1002/cncr.1980.45.s7.1879

subject

Has Abstract

pub_date

1980-04-01 00:00:00

pages

1879-1888

eissn

0008-543X

issn

1097-0142

journal_volume

45 Suppl 7

pub_type

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