Abstract:
:Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with methotrexate alone. Response rate was increased to 76.2% with addition of cisplatin to methotrexate. Small lesions (less than 10 cm) showed better response as compared to advanced cases. Therapy was generally well tolerated and good palliation was obtained even after the first course. Postchemotherpy treatment either with surgery or radiotherapy was tolerated without any major complications. The data confirm the short-term usefulness of initial chemotherapy with methotrexate and cisplatin in esophageal cancer. Results of prolonged follow-up will help to evaluate the role of front loading chemotherapy on long-term survival.
journal_name
Cancerjournal_title
Cancerauthors
Advani SH,Saikia TK,Swaroop S,Ramakrishnan G,Nair CN,Dinshaw KA,Sharma S,Vyas JJ,Desai PBdoi
10.1002/1097-0142(19851001)56:7<1502::aid-cncr2820subject
Has Abstractpub_date
1985-10-01 00:00:00pages
1502-6issue
7eissn
0008-543Xissn
1097-0142journal_volume
56pub_type
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