Sentinel lymph node versus axillary lymph node dissection for early-stage breast carcinoma: a comparison using a utility-adjusted number needed to treat analysis.

Abstract:

BACKGROUND:The current study was performed to compare the value of sentinel lymph node dissection (SND) and axillary lymph node dissection (AND) in improving the utility-adjusted survival for early-stage breast carcinoma patients. METHODS:A number needed to treat (NNT) analysis was used to compare SND with AND. In the NNT equation, 1/(S(SND) - S(AND)), S is the 5-year utility-adjusted survival. A literature review was performed to estimate 1) the prevalence of axillary lymph node disease for early-stage breast carcinoma, 2) the sensitivity and specificity of SND and AND, 3) the 5-year overall survival as a function of axillary lymph node involvement, 4) the risk of arm lymphedema as a function of the intervention performed, and 5) the utility correction (Uc; impairment of quality of life) for arm lymphedema. RESULTS:The NNT method of analysis favored SND over nearly the entire range of parameters with a sign change to a negative value occurring only as Uc becomes very close to unity. This suggests the superiority of the SND approach. Only when there is minimal loss of utility does AND become favored and then only minimally. CONCLUSIONS:Compared with AND, SND improves the utility-adjusted survival in patients with early-stage breast carcinoma. This finding is quite robust and was found to remain constant over a range of values for utility and lymph node prevalence.

journal_name

Cancer

journal_title

Cancer

authors

Jani AB,Basu A,Heimann R,Hellman S

doi

10.1002/cncr.11081

subject

Has Abstract

pub_date

2003-01-15 00:00:00

pages

359-66

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

97

pub_type

杂志文章

相关文献

CANCER文献大全
  • Enzyme pattern and marker antigens in nodular "regenerative" hyperplasia of the liver.

    abstract::Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was dem...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810401)47:7<1796::aid-cncr2820

    authors: Thung SN,Gerber MA

    更新日期:1981-04-01 00:00:00

  • Bone-marrow examination in the staging of small-cell anaplastic carcinoma of the lung with special reference to subtyping. An evaluation of 203 consecutive patients.

    abstract::Histologic examination of bone-marrow from the posterior iliac crest was routinely done as a pretreatment staging procedure in 203 consecutive patients with small-cell anaplastic carcinoma of the lung. Subtyping of the patients according to the WHO classification included 27.8% with "fusiform" cell type (WHO II,1), 28...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197706)39:6<2563::aid-cncr282039

    authors: Hirsch F,Hansen HH,Dombernowsky P,Hainau B

    更新日期:1977-06-01 00:00:00

  • Caregiver symptom burden: the risk of caring for an underserved patient with advanced cancer.

    abstract:BACKGROUND:The growing diversity of the population of the United States and the high burden of cancer-related symptoms reflect the need for caregiver research within underserved groups. In this longitudinal study, the authors assessed changes in symptom severity in caregivers and underserved minority patients diagnosed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25695

    authors: Palos GR,Mendoza TR,Liao KP,Anderson KO,Garcia-Gonzalez A,Hahn K,Nazario A,Ramondetta LM,Valero V,Lynch GR,Jibaja-Weiss ML,Cleeland CS

    更新日期:2011-03-01 00:00:00

  • Cytogenetic studies of chronic myelocytic leukemia in children and adolescents.

    abstract::In a 3 1/2 year cytogenetic study of 107 leukemia patients diagnosed in childhood and adloescence, 8 presented with chronic myelogenous leukemia (CML). Seven of the 8 had chromosomal abnormalities. Six had the Ph1 chromosome; 5 had the usual 9;22 translocation. Two patients had involvement with chromosome 15; one had ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197907)44:1<210::aid-cncr2820440

    authors: Hays T,Morse H,Peakman D,Rose B,Robinson A

    更新日期:1979-07-01 00:00:00

  • The National Cancer Data Base. Report on colon cancer.

    abstract:BACKGROUND:Commission on Cancer data from the National Cancer Data Base (NCDB) report time trends in stage of disease, treatment patterns, and survival for patients with selected cancers. The most current data (1993) for patients with colon cancer are described. METHODS:Five calls for data yielded 3,700,000 cases of c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960815)78:4<918::AID-CNC

    authors: Jessup JM,McGinnis LS,Steele GD Jr,Menck HR,Winchester DP

    更新日期:1996-08-15 00:00:00

  • Proton therapy for low-grade gliomas: Results from a prospective trial.

    abstract:BACKGROUND:In this prospective study, the authors evaluated potential treatment toxicity and progression-free survival in patients with low-grade glioma who received treatment with proton radiation therapy. METHODS:Twenty patients with World Health Organization grade 2 glioma who were eligible for radiation therapy we...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.29237

    authors: Shih HA,Sherman JC,Nachtigall LB,Colvin MK,Fullerton BC,Daartz J,Winrich BK,Batchelor TT,Thornton LT,Mancuso SM,Saums MK,Oh KS,Curry WT,Loeffler JS,Yeap BY

    更新日期:2015-05-15 00:00:00

  • Racial differences in colorectal cancer survival in the Detroit Metropolitan Area.

    abstract:BACKGROUND:Colorectal carcinoma is the second most common cause of cancer death with African Americans having lower survival compared with White Americans. The purpose of this study was to investigate the effect of demographics, clinical factors, and socioeconomic status (SES) on racial disparities in colorectal cancer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24408

    authors: Yan B,Noone AM,Yee C,Banerjee M,Schwartz K,Simon MS

    更新日期:2009-08-15 00:00:00

  • Screening young adult cancer survivors with the PROMIS Depression Short Form (PROMIS-D-SF): Comparison with a structured clinical diagnostic interview.

    abstract:BACKGROUND:The current study was conducted to evaluate the Patient-Reported Outcomes Measurement Information System Depression Short Form (PROMIS-D-SF) as a screening measure for young adult cancer survivors (YACS) compared with a structured diagnostic interview. METHODS:A total of 249 YACS (aged 18-40 years) complete...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32689

    authors: Recklitis CJ,Blackmon JE,Chang G

    更新日期:2020-04-01 00:00:00

  • Elevation of serum lactic dehydrogenase levels as an early marker of occult malignant lymphoma.

    abstract::Elevated serum lactic dehydrogenase (LDH) levels, 595 to 615 microns/ml (normal less than 225 microns/ml) with predominance of LDH isoenzymes 2 and 3 was the early and only sign of occult malignant lymphoma in three patients. In the first patient, overt lymphoma appeared clinically only 2 months after the finding of e...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841001)54:7<1379::aid-cncr2820

    authors: Rotenberg Z,Weinberger I,Fuchs Y,Erdberg A,Davidson E,Agmon J

    更新日期:1984-10-01 00:00:00

  • The prognostic value of histologic subtypes in primary extremity liposarcoma.

    abstract::Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820

    authors: Chang HR,Hajdu SI,Collin C,Brennan MF

    更新日期:1989-10-01 00:00:00

  • Comparative genomic hybridization of esophageal squamous cell carcinoma: correlations between chromosomal aberrations and disease progression/prognosis.

    abstract:BACKGROUND:Esophageal carcinoma is a major cause of cancer-related deaths among males in Taiwan. However, to date, the genetic alterations that accompany this lethal disease are not understood. METHODS:Chromosomal aberrations of 46 samples of esophageal squamous cell carcinoma (EC-SCC) were analyzed by comparative gen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20011201)92:11<2769::aid-cncr101

    authors: Yen CC,Chen YJ,Chen JT,Hsia JY,Chen PM,Liu JH,Fan FS,Chiou TJ,Wang WS,Lin CH

    更新日期:2001-12-01 00:00:00

  • Extended-field radiation therapy for carcinoma of the cervix.

    abstract::The survival of cervical carcinoma patients with paraaortic/high common iliac nodal metastases was evaluated by retrospective chart review during a 13-year interval. Thirty-three patients with cervical carcinoma and surgically documented nodal metastases received primary, extended-field radiation therapy. Overall 2-ye...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900715)66:2<251::aid-cncr28206

    authors: Podczaski E,Stryker JA,Kaminski P,Ndubisi B,Larson J,DeGeest K,Sorosky J,Mortel R

    更新日期:1990-07-15 00:00:00

  • Parathyroid carcinoma of the oxyphil cell type. A report of two cases, light and electron microscopic study.

    abstract::Parathyroid adenomas are subdivided into chief cell and oxyphil cell variants. However, the parathyroid carcinomas described thus far have been only of the chief cell type. Two cases of oxyphil cell carcinoma of the parathyroid gland are reported, with light and electron microscopic study. The patients presented appar...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850401)55:7<1482::aid-cncr2820

    authors: Obara T,Fujimoto Y,Yamaguchi K,Takanashi R,Kino I,Sasaki Y

    更新日期:1985-04-01 00:00:00

  • I. Carcinoma of the rectum and rectosigmoid: cancer specific long-term survival. A series of 1061 cases treated by one surgeon.

    abstract::The long-term cancer specific survival based on individual follow-up and analysis of prospectively collected data from 1061 patients undergoing resection for carcinoma of the rectum is presented. All patients were operated on and managed by one surgeon. Survival data for 978 cases were analyzed according to the method...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800601)45:11<2902::aid-cncr282

    authors: Pihl E,Hughes ES,McDermott FT,Milne BJ,Korner JM,Price AB

    更新日期:1980-06-01 00:00:00

  • Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum.

    abstract::This study explores the patterns of recurrence after "curative" operation for colorectal cancer. For an 11-year period, 1960-1971, 281 evaluable patients were resected at the Peter Bent Brigham Hospital. Crude five-year survival in these patients was 49%, but only 10% of those with recurrence lived five years. A total...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800615)45:12<2969::aid-cncr282

    authors: Olson RM,Perencevich NP,Malcolm AW,Chaffey JT,Wilson RE

    更新日期:1980-06-15 00:00:00

  • A prospective pilot study to evaluate a new dental assessment and treatment paradigm for patients scheduled to undergo intensive chemotherapy for cancer.

    abstract:BACKGROUND:Patients scheduled to receive chemotherapy frequently undergo pretherapy dental treatment to eliminate potential sources of odontogenic infection. A prospective study was conducted to assess a new protocol emphasizing minimal pretherapy dental treatment. METHODS:Forty-eight consecutive patients diagnosed wi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Toljanic JA,Bedard JF,Larson RA,Fox JP

    更新日期:1999-04-15 00:00:00

  • Protease inhibitors and carcinoma of the esophagus.

    abstract:BACKGROUND:Squamous cell carcinoma of the esophagus is endemic in parts of South Africa. Previous case-control studies have shown many associations but no clear etiologic pathway has been established. METHODS:A case-control study of dietary and social factors was performed for 130 patient/control pairs matched for age...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Sammon AM

    更新日期:1998-08-01 00:00:00

  • Brain metastasis from renal cell carcinoma: presentation, recurrence, and survival.

    abstract:BACKGROUND:Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guideline...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23769

    authors: Shuch B,La Rochelle JC,Klatte T,Riggs SB,Liu W,Kabbinavar FF,Pantuck AJ,Belldegrun AS

    更新日期:2008-10-01 00:00:00

  • Two primary carcinomas of the lung: adenocarcinoma and a metachronous squamous cell carcinoma. A case report and review of the literature.

    abstract::The case of a patient who underwent a left lower lobe lobectomy for adenocarcinoma of the lung and developed a metachronous squamous cell carcinoma of the right lung eight years later, is presented. The unusual nature of the case is emphasized utilizing a review of the literature. The criteria for diagnosing metachron...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19830101)51:1<124::aid-cncr28205

    authors: Coffman B,Crum E,Forman WB

    更新日期:1983-01-01 00:00:00

  • Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors.

    abstract:BACKGROUND:Neuropilins (NRPs) are characterized as coreceptors of vascular endothelial growth factor (VEGF). In the current study, the authors assessed the expression of NRPs, VEGF, and vascular endothelial growth factor receptors (VEGFRs), as well as VEGF-induced cell proliferation, in pancreatic carcinoma cell lines ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20634

    authors: Li M,Yang H,Chai H,Fisher WE,Wang X,Brunicardi FC,Yao Q,Chen C

    更新日期:2004-11-15 00:00:00

  • Low clinical trial accrual of patients with myelodysplastic syndromes: Causes and potential solutions.

    abstract::Despite few effective therapies, only a small percentage of patients diagnosed with myelodysplastic syndromes (MDS) in the United States are enrolled in prospective, interventional clinical trials. MDS-specific barriers to trial accrual include a high frequency of elderly patients with comorbid conditions, atypical di...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31769

    authors: Steensma DP,Brunner AM,DeZern AE,Garcia-Manero G,Komrokji RS,Odenike OS,Roboz GJ,Savona MR,Stone RM,Sekeres MA

    更新日期:2018-12-15 00:00:00

  • Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514.

    abstract:BACKGROUND:The use of neoadjuvant and adjuvant chemotherapy in soft tissue sarcomas is controversial. This is a report of long-term (≥5 years) follow-up in patients with high-grade, high-risk soft tissue sarcomas treated with neoadjuvant chemotherapy, preoperative radiotherapy (RT), and adjuvant chemotherapy. METHODS:...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.25350

    authors: Kraybill WG,Harris J,Spiro IJ,Ettinger DS,DeLaney TF,Blum RH,Lucas DR,Harmon DC,Letson GD,Eisenberg B

    更新日期:2010-10-01 00:00:00

  • A prospective evaluation of the durability of palliative interventions for patients with metastatic breast cancer.

    abstract:BACKGROUND:Although systemic therapy for metastatic breast cancer (MBC) continues to evolve, there are scant data to guide physicians and patients when symptoms develop. In this article, the authors report the frequency and durability of palliative procedures performed in the setting of MBC. METHODS:From July 2002 to ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25034

    authors: Morrogh M,Miner TJ,Park A,Jenckes A,Gonen M,Seidman A,Morrow M,Jaques DP,King TA

    更新日期:2010-07-15 00:00:00

  • Medical oncology and geriatric medicine: is it time for fellowship integration?

    abstract::Although training programs exist in both medical oncology and geriatrics (approved by the American Board of Internal Medicine), neither is adequate to ensure an appropriate supply of physicians to assume a leadership role in the treatment of the increasing number of geriatric patients who have or will develop a malign...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971001)80:7<1351::aid-cn

    authors: Bennett JM,Sahasrabudhe DM,Hall WJ

    更新日期:1997-10-01 00:00:00

  • Lymphoma of the thyroid. An unusual clinical course in a patient possessing a 14/21 translocation.

    abstract::The unusual course of a lymphoma in a woman with a chromosome abnormality is reported. When aged 30 years, the right lobe of her thyroid gland was found to be infiltrated by a follicular lymphoma. Two years later, poorly differentiated diffuse lymphoctic lymphoma recurred locally, grew rapidly, and infiltrated the adj...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197607)38:1<259::aid-cncr2820380

    authors: Langlands AO,MacLean N

    更新日期:1976-07-01 00:00:00

  • Common expression of parathyroid hormone-related protein and no correlation of calcium level in renal cell carcinomas.

    abstract:BACKGROUND:Parathyroid hormone-related protein (PTHrP) is the predominant cause of humoral hypercalcemia of malignancy (HHM). METHODS:Using a PTHrP-specific monoclonal antibody (MoAb), 4B3, the authors investigated the immunohistochemical localization of PTHrP in formalin-fixed and paraffin-embedded sections of normal...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930501)71:9<2803::aid-cncr2820

    authors: Gotoh A,Kitazawa S,Mizuno Y,Takenaka A,Arakawa S,Matsumoto O,Kitazawa R,Fujimori T,Maeda S,Kamidono S

    更新日期:1993-05-01 00:00:00

  • Clinical evaluation of specific gamma-GTP isoenzyme in patients with hepatocellular carcinoma.

    abstract::The authors evaluated specific gamma-GTP isoenzyme (specific gamma-GTP) found in sera of patients with hepatocellular carcinoma (HCC). In addition to band II and II' which had been reported in our previous publication, band I' also had a high specificity for HCC. One or more of these bands were detectable in 109 (55%)...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830115)51:2<327::aid-cncr28205

    authors: Sawabu N,Nakagen M,Ozaki K,Wakabayashi T,Toya D,Hattori N,Ishii M

    更新日期:1983-01-15 00:00:00

  • Primary lymphoma of the breast: ultrastructural study of two cases.

    abstract::Two cases of primary non-Hodgkin's lymphomas of the breast were studied with light and electron microscopy. By light microscopy, according to Rappaport's classification, one was a poorly differentiated lymphocytic lymphoma, the other a diffuse histiocytic lymphoma. However, the ultrastructural features of the latter w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197705)39:5<2025::aid-cncr282039

    authors: Navas JJ,Battifora H

    更新日期:1977-05-01 00:00:00

  • Lymphatic flow in carcinoma of the distal bile duct based on a clinicopathologic study.

    abstract:BACKGROUND:Nodal status is one of the most important prognostic factors for distal bile duct cancer. The pattern of lymphatic spread of distal bile duct cancer was analyzed by determining the frequency of involvement of various lymph nodes. MATERIALS AND METHODS:From 1973 to 1991, 29 patients with distal bile duct can...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931001)72:7<2112::aid-cncr2820

    authors: Kayahara M,Nagakawa T,Ueno K,Ohta T,Takeda T,Miyazaki I

    更新日期:1993-10-01 00:00:00

  • Does socioeconomic status account for racial and ethnic disparities in childhood cancer survival?

    abstract:BACKGROUND:For many childhood cancers, survival is lower among non-Hispanic blacks and Hispanics in comparison with non-Hispanic whites, and this may be attributed to underlying socioeconomic factors. However, prior childhood cancer survival studies have not formally tested for mediation by socioeconomic status (SES). ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31560

    authors: Kehm RD,Spector LG,Poynter JN,Vock DM,Altekruse SF,Osypuk TL

    更新日期:2018-10-15 00:00:00