Enzyme pattern and marker antigens in nodular "regenerative" hyperplasia of the liver.

Abstract:

:Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was demonstrated in a case of nodular "regenerative" hyperplasia of liver. The lack of marker antigens (alphafetoprotein, carcinoembryonic antigen, alpha 1-antitrypsin) in the hyperplastic nodules in this patient may be related to the discontinuation of oral contraceptive steroids four years earlier. The phenotypic changes of enzyme activity suggest that nodular "regenerative" hyperplasia of the liver in man is preneoplastic.

journal_name

Cancer

journal_title

Cancer

authors

Thung SN,Gerber MA

doi

10.1002/1097-0142(19810401)47:7<1796::aid-cncr2820

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

1796-9

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

47

pub_type

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