Abstract:
:Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was demonstrated in a case of nodular "regenerative" hyperplasia of liver. The lack of marker antigens (alphafetoprotein, carcinoembryonic antigen, alpha 1-antitrypsin) in the hyperplastic nodules in this patient may be related to the discontinuation of oral contraceptive steroids four years earlier. The phenotypic changes of enzyme activity suggest that nodular "regenerative" hyperplasia of the liver in man is preneoplastic.
journal_name
Cancerjournal_title
Cancerauthors
Thung SN,Gerber MAdoi
10.1002/1097-0142(19810401)47:7<1796::aid-cncr2820subject
Has Abstractpub_date
1981-04-01 00:00:00pages
1796-9issue
7eissn
0008-543Xissn
1097-0142journal_volume
47pub_type
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