The role of radical surgery in the management of radiation recurrent and large volume prostate cancer.

Abstract:

:Twenty-two patients seen between 1975 and 1988 were analyzed who had surgical attempts to cure locally advanced prostate cancer by exenterative procedures or salvage surgery for radiation recurrent disease. Twelve patients (Group I) underwent either a salvage cystoprostatectomy or perineal prostatectomy for radiorecurrent disease, including three patients with a Kock continent urinary diversion done in combination with the salvage operation. Five of the 12 (41.7%) recurrent disease confined to the surgical specimen and 11 of 12 (91.7%) are alive at a mean follow-up of 49 months, including four patients (25%) with a completely negative serum prostate-specific antigen (PSA) value (less than 0.2 ng/dl). All perineal prostatectomy patients are continent, and two of the three Kock pouch patients are continent. Ten of the 22 patients (Group II) had a cystoprostatectomy or exenteration for locally advanced disease that the surgeon did not think was amenable to standard radical prostatectomy. Only one of these ten patients had negative surgical margins, capsule, and seminal vesicles. Nine are alive (although only one patient has no evidence of disease) at a mean follow-up of 59 months. Morbidity was substantial with a 50% major complication rate including four patients requiring reoperation because of bleeding, abscess, bowel obstruction, or colostomy closure. Salvage procedures for radiorecurrent disease can be done safely, even with the inclusion of a continent diversion, and may be curative or provide survival benefit to carefully selected patients. Cystoprostatectomy or exenteration for locally advanced disease does not appear to be a curative endeavor for most patients and may be accompanied by significant morbidity.

journal_name

Cancer

journal_title

Cancer

authors

Moul JW,Paulson DF

doi

10.1002/1097-0142(19910915)68:6<1265::aid-cncr2820

subject

Has Abstract

pub_date

1991-09-15 00:00:00

pages

1265-71

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

68

pub_type

杂志文章

相关文献

CANCER文献大全
  • Tissue diagnosis for carcinoma of the pancreas and periampullary structures.

    abstract::In a county hospital, 217 patients were operated on for suspected cancer of the pancreas (186 patients) and periampullary structures (31 patients). The surgeons' philosophy was to avoid biopsy of the pancreas whenever possible, they often performed radical resection based on clinical judgment alone (8% of the resectio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820301)49:5<1035::aid-cncr2820

    authors: Lee YT

    更新日期:1982-03-01 00:00:00

  • Pathologic findings and clinical outcome of patients undergoing retroperitoneal lymph node dissection after multiple chemotherapy regimens for metastatic testicular germ cell tumors.

    abstract:BACKGROUND:Postchemotherapy surgery is an essential component in the management of patients with metastatic germ cell tumors (GCT). The authors assessed their institutional experience of retroperitoneal lymph node dissection (RPLND) after multiple chemotherapy regimens for advanced GCT. METHODS:By analyzing the instit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22440

    authors: Eggener SE,Carver BS,Loeb S,Kondagunta GV,Bosl GJ,Sheinfeld J

    更新日期:2007-02-01 00:00:00

  • Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas.

    abstract:BACKGROUND:The 5-year survival rate of patients with submucosal (sm) esophageal carcinoma continues to be much worse than that with intramucosal (m) lesions. The reasons are unclear, but matrix metalloproteinases (MMPs) and membrane type matrix metalloproteinases (MT-MMPs) are known to be involved in degradation of ext...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Ohashi K,Nemoto T,Nakamura K,Nemori R

    更新日期:2000-05-15 00:00:00

  • French registry of acute leukemia and myelodysplastic syndromes. Age distribution and hemogram analysis of the 4496 cases recorded during 1982-1983 and classified according to FAB criteria. Groupe Francais de Morphologie Hematologique.

    abstract::During 1982 and 1983, 4496 new cases were recorded in the French Registry of acute leukemia and myelodysplastic syndromes by the French Group of Hematologic Morphology. This cooperative group associated members of 37 university centers spread throughout France; these centers handle the overwhelming majority of acute l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1987-09-15 00:00:00

  • Distinct cytogenetic and clinicopathologic features in acute myeloid leukemia after occupational exposure to pesticides and organic solvents.

    abstract:BACKGROUND:To study the correlation of environmental exposure to potentially mutagenic agents and the clinicopathologic picture in acute myeloid leukemia (AML), clinical features, morphologic characteristics, immunophenotype, and cytogenetics were studied in 59 patients with newly diagnosed AML. METHODS:Based on inter...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920701)70:1<77::aid-cncr282070

    authors: Fagioli F,Cuneo A,Piva N,Carli MG,Previati R,Balboni M,Tomasi P,Cariani D,Scapoli G,Castoldi G

    更新日期:1992-07-01 00:00:00

  • A safe and effective method for converting patients from transdermal to intravenous fentanyl for the treatment of acute cancer-related pain.

    abstract:BACKGROUND:The delayed effects (12-16 hours) of transdermal fentanyl make dose titration difficult during acute exacerbations of cancer pain. Patients at the authors' institution routinely are switched from transdermal to intravenous (IV) fentanyl using a 1:1 (transdermal:IV) conversion during severe episodes of pain. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11457

    authors: Kornick CA,Santiago-Palma J,Schulman G,O'Brien PC,Weigand S,Payne R,Manfredi PL

    更新日期:2003-06-15 00:00:00

  • Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results.

    abstract::Ninety-five malignant tumors in the submandibular gland, the sublingual gland, and the minor salivary glands seen in a 25-year period were reviewed. The patients were retrospectively staged using the Union Internationale Contre le Cancer (UICC) classification. The most frequent tumor was adenoid cystic carcinoma, foll...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911201)68:11<2431::aid-cncr282

    authors: Andersen LJ,Therkildsen MH,Ockelmann HH,Bentzen JD,Schiødt T,Hansen HS

    更新日期:1991-12-01 00:00:00

  • A phase II study of "decrescendo" interleukin-2 plus interferon-alpha-2a in patients with progressive metastatic melanoma after chemotherapy.

    abstract:BACKGROUND:The authors tested a biotherapy regimen involving recombinant interferon-alpha-2a (rIFN-alpha-2a) and recombinant human interleukin-2 (rhIL-2), given in a "decrescendo" schedule over 5 days, for its activity and toxicity in 21 patients who previously had received chemotherapy for advanced melanoma. METHODS:...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Eton O,Buzaid AC,Bedikian AY,Smith TM,Papadopoulos NE,Ellerhorst JA,Hibberts JL,Legha SS,Benjamin RS

    更新日期:2000-04-01 00:00:00

  • Long-term outcome in localized extranodal mucosa-associated lymphoid tissue lymphomas treated with radiotherapy.

    abstract:BACKGROUND:This study was conducted to evaluate the long-term outcomes in patients with stage IE and IIE mucosa-associated lymphoid tissue (MALT) lymphomas treated with involved field radiotherapy (RT). METHODS:Between 1989 and 2004, 192 patients with stage I and II MALT lymphomas were treated. The report focuses on 1...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25226

    authors: Goda JS,Gospodarowicz M,Pintilie M,Wells W,Hodgson DC,Sun A,Crump M,Tsang RW

    更新日期:2010-08-15 00:00:00

  • Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with radiotherapy-chemotherapy: study of 34 cases and review of the literature.

    abstract::Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with chemotherapy and radiotherapy to the chest and brain. Emphasis was placed on analysis of patterns of chest disease relapse, chest complications, and sites of initial chest disease relapse in relation to volume ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801215)46:12<2557::aid-cncr282

    authors: Mira JG,Livingston RB

    更新日期:1980-12-15 00:00:00

  • Organ modeling in the quantitation of planar images for distribution studies.

    abstract:BACKGROUND:The advantage of whole-body imaging for distribution studies is that it accounts for all activities. The problem, however, is that the classic approach to determining distribution from planar images does not accommodate overlapping structures. That approach assumes implicitly that the sampling region is a pr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940201)73:3+<919::aid-cncr2820

    authors: Goris ML,Knox SA,Nielsen KR,Bouillant O

    更新日期:1994-02-01 00:00:00

  • Prognostic factors in laryngeal carcinoma. Experience in 296 male patients.

    abstract:BACKGROUND:Laryngeal cancer is the primary cause of death among patients with head and neck cancer in Argentina. Different prognostic factors have been incidentally dealt with in a number of articles, but there are few studies of prognostic variables, such as age, tobacco, and alcohol, using multifactorial analysis. M...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930415)71:8<2472::aid-cncr2820

    authors: Pradier R,González A,Matos E,Loria D,Adan R,Saco P,Califano L

    更新日期:1993-04-15 00:00:00

  • Genetic variants in one-carbon metabolism-related genes contribute to NSCLC prognosis in a Chinese population.

    abstract:BACKGROUND:One-carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one-carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25301

    authors: Jin G,Huang J,Hu Z,Dai J,Tang R,Chen Y,Xu L,Huang X,Shu Y,Shen H

    更新日期:2010-12-15 00:00:00

  • The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas.

    abstract:BACKGROUND:Increasing knowledge of cancer genomes has triggered the development of specific targeted inhibitors, thus providing a valuable therapeutic pool. METHODS:In this report, the authors analyze the presence of targetable alterations in 136 tumor samples from 92 patients with melanoma using a comprehensive appro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31843

    authors: Appenzeller S,Gesierich A,Thiem A,Hufnagel A,Jessen C,Kneitz H,Regensburger M,Schmidt C,Zirkenbach V,Bischler T,Schilling B,Siedel C,Goebeler ME,Houben R,Schrama D,Gehrig A,Rost S,Maurus K,Bargou R,Rosenwald A,Sch

    更新日期:2019-02-15 00:00:00

  • The National Cancer Data Base report on carcinoma of the gallbladder, 1989-1995.

    abstract:BACKGROUND:Reports utilizing data from the Commission on Cancer's National Cancer Data Base (NCDB) have previously contained evaluations of time trends for stage of disease at diagnosis, treatment, and survival for multiple tumor sites. Data collected from 1989, 1990, 1994, and 1995 for carcinoma of the gallbladder are...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19981215)83:12<2618::aid-c

    authors: Donohue JH,Stewart AK,Menck HR

    更新日期:1998-12-15 00:00:00

  • Prevalence and clinical implications of cyclin D1 expression in diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program.

    abstract:BACKGROUND:Cyclin D1 expression has been reported in a subset of patients with diffuse large B-cell leukemia (DLBCL), but studies have been few and generally small, and they have demonstrated no obvious clinical implications attributable to cyclin D1 expression. METHODS:The authors reviewed 1435 patients who were diag...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28664

    authors: Ok CY,Xu-Monette ZY,Tzankov A,O'Malley DP,Montes-Moreno S,Visco C,Møller MB,Dybkaer K,Orazi A,Zu Y,Bhagat G,Richards KL,Hsi ED,Han van Krieken J,Ponzoni M,Farnen JP,Piris MA,Winter JN,Medeiros LJ,Young KH

    更新日期:2014-06-15 00:00:00

  • Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor.

    abstract:BACKGROUND:Alveolar soft part sarcoma (ASPS), chondrosarcoma (CS), chordoma, epithelioid sarcoma, and solitary fibrous tumor (SFT) are malignant tumors that are relatively resistant to chemotherapy and for which more effective drug therapy is needed. METHODS:The 5 listed subtypes were enrolled into a single indolent s...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.30379

    authors: Schuetze SM,Bolejack V,Choy E,Ganjoo KN,Staddon AP,Chow WA,Tawbi HA,Samuels BL,Patel SR,von Mehren M,D'Amato G,Leu KM,Loeb DM,Forscher CA,Milhem MM,Rushing DA,Lucas DR,Chugh R,Reinke DK,Baker LH

    更新日期:2017-01-01 00:00:00

  • Positive impact of the Patient Protection and Affordable Care Act Medicaid expansion on Louisiana women with breast cancer.

    abstract:BACKGROUND:Louisiana is one of the few Southern states that enacted the Medicaid expansion of the Patient Protection and Affordable Care Act (ACA). To the authors' knowledge, the issue of how this has affected the breast cancer landscape in Louisiana is unknown. The authors have postulated that ACA expansion had a posi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33265

    authors: Chu QD,Li T,Hsieh MC,Yi Y,Gibbs JF,Lyons JM 3rd,Wu XC

    更新日期:2020-11-03 00:00:00

  • Mammographically guided fine-needle aspiration biopsy of nonpalpable breast lesions. Can it replace open biopsy?

    abstract::The authors report the accuracy of mammographically guided fine-needle aspiration (FNA) for the diagnosis of nonpalpable breast lesions in a series of 71 patients. Each mammographically guided FNA was immediately followed by hookwire localization and open biopsy. Seven malignancies were identified cytologically, but t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911101)68:9<2007::aid-cncr2820

    authors: Layfield LJ,Parkinson B,Wong J,Giuliano AE,Bassett LW

    更新日期:1991-11-01 00:00:00

  • Association of Langerhans cell histiocytosis with malignant neoplasms.

    abstract:BACKGROUND:The association of Langerhans cell histiocytosis (LCH) with a malignant neoplasm is rare and generally has been the subject of isolated case reports. METHODS:A recent case of LCH seen at the University of Minnesota in combination with acute lymphoblastic leukemia led the authors to review their own charts f...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930201)71:3<865::aid-cncr28207

    authors: Egeler RM,Neglia JP,Puccetti DM,Brennan CA,Nesbit ME

    更新日期:1993-02-01 00:00:00

  • Gut microbiota-immune-brain interactions in chemotherapy-associated behavioral comorbidities.

    abstract::Increasing scientific attention is focused on the gut-brain axis, including the ability of the gastrointestinal (GI) tract to modulate central nervous system function. Changes in the intestinal microbiome can influence affective-like behavior, cognitive performance, fatigue, and sleep in rodents and humans. Patients w...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.31584

    authors: Jordan KR,Loman BR,Bailey MT,Pyter LM

    更新日期:2018-10-15 00:00:00

  • Changing prognosis of metastatic colorectal adenocarcinoma: Differential improvement by age and tumor location.

    abstract:BACKGROUND:Over the past 2 decades, significant progress has been made in the field of metastatic colorectal cancer (mCRC) regarding new imaging techniques, surgical interventions, and systemic therapy. It is not known whether the benefit from these interventions has extended overall survival (OS) within the general mC...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28143

    authors: Golan T,Urban D,Berger R,Lawrence YR

    更新日期:2013-08-15 00:00:00

  • Relationship between androgen receptor binding activity in human prostate cancer and clinical response to endocrine therapy.

    abstract::The authors investigated the ability of androgen receptor binding in prostate cancer tissue to predict the response of prostate cancer patients to endocrine therapy. The clinical response of 37 previously untreated patients with various grades and stages of prostate cancer was correlated with androgen receptor binding...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870501)59:9<1599::aid-cncr2820

    authors: Benson RC Jr,Gorman PA,O'Brien PC,Holicky EL,Veneziale CM

    更新日期:1987-05-01 00:00:00

  • Serum acute phase reactants and prognosis in renal cell carcinoma.

    abstract:BACKGROUND:Inflammatory parameters as acute phase proteins commonly are elevated in patients with renal cell carcinoma. Some of these acute phase reactants have been proposed to influence survival. METHODS:In 170 patients with renal cell carcinoma, the authors studied six acute phase reactant parameters (erythrocyte s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951015)76:8<1435::aid-cncr2820

    authors: Ljungberg B,Grankvist K,Rasmuson T

    更新日期:1995-10-15 00:00:00

  • Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapy.

    abstract::The c-Met/hepatocyte growth factor receptor and its family members are known to promote cancer cell migration and invasion. Signaling within and beyond this pathway contributes to the systemic spread of metastases through induction of the epithelial-mesenchymal transition, a process also implicated in mediating resist...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.27965

    authors: Bhardwaj V,Cascone T,Cortez MA,Amini A,Evans J,Komaki RU,Heymach JV,Welsh JW

    更新日期:2013-05-15 00:00:00

  • Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study.

    abstract:BACKGROUND:A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS:Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 aerobic c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23967

    authors: Jones LW,Eves ND,Peterson BL,Garst J,Crawford J,West MJ,Mabe S,Harpole D,Kraus WE,Douglas PS

    更新日期:2008-12-15 00:00:00

  • Activated CD4-positive T-lymphocytes and impaired cell-mediated immunity in patients with carcinoma of the urinary bladder with schistosomiasis.

    abstract::Patients with schistosomiasis of the urinary bladder (SB) associated with carcinoma of the bladder (SCB) or carcinoma of the prostate (SCP) have a variety of immunologic abnormalities, including the presence of HLA-DR+ and interleukin-2 receptor-positive (IL-2R+) T-lymphocytes in circulating blood. This study demonstr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900215)65:4<931::aid-cncr28206

    authors: Raziuddin S,Shetty S,Ibrahim A,Patil K

    更新日期:1990-02-15 00:00:00

  • Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features: National Cancer Data Base.

    abstract:BACKGROUND:There has been increasing interest in the primary surgical treatment of patients with early T classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de-escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest h...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29938

    authors: Cracchiolo JR,Baxi SS,Morris LG,Ganly I,Patel SG,Cohen MA,Roman BR

    更新日期:2016-05-15 00:00:00

  • Multimodality therapy in the management of angiosarcoma of the breast.

    abstract::Five patients with angiosarcoma of the breast were treated with surgery, radiotherapy and an adjuvant Adriamycin containing regimen. Two patients remain disease-free at 38+ and 20+ months. The median survival of previously reported cases is 22 months with only five patients disease-free at five years. Possible hormona...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821115)50:10<2000::aid-cncr282

    authors: Antman KH,Corson J,Greenberger J,Wilson R

    更新日期:1982-11-15 00:00:00

  • Typhlitis in childhood cancer.

    abstract:BACKGROUND:Typhlitis is increasingly recognized in children undergoing chemotherapy but is poorly characterized. The authors investigated the demographic, clinical, and imaging (ultrasonography and computed tomography [CT] scans) variables related to the diagnosis, risk, and outcome of typhlitis. METHODS:The authors r...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21134

    authors: McCarville MB,Adelman CS,Li C,Xiong X,Furman WL,Razzouk BI,Pui CH,Sandlund JT

    更新日期:2005-07-15 00:00:00