Abstract:
:Carboplatin (diammine [1,1-cyclobutanedicarboxylate(2-)-O,o']platinum) is a second generation platinum coordination complex. It has a spectrum of activity that is similar to that of cisplatin and is less nephrotoxic and emetogenic in experimental animals. Fifty-two 30-minute infusions of carboplatin were given to 20 evaluable patients with a variety of solid tumors. Maximum tolerated dose was 440 mg/m2. Thrombocytopenia (less than 100,000/mm3) occurred in six of seven patients; two patients experienced a leukocyte count less than 2000/mm3. Platelet and leukocyte count nadirs occurred on day 21. No nephrotoxicity was seen. Blood urea nitrogen, serum creatine levels, and creatinine clearances remained normal, and no consistent elevation of urinary beta 2-microglobulin, leucine aminopeptidase, or N-acetyl-beta-glucosaminidase occurred. Nausea and vomiting were mild to moderate. A single patient developed mild peripheral neuropathy. No auditory toxicity was noted. The recommended dose for Phase II studies is 400 mg/m2 every 28 days for good risk patients; heavily pretreated patients should receive 320 mg/m2.
journal_name
Cancerjournal_title
Cancerauthors
Koeller JM,Trump DL,Tutsch KD,Earhart RH,Davis TE,Tormey DCdoi
10.1002/1097-0142(19860115)57:2<222::aid-cncr28205subject
Has Abstractpub_date
1986-01-15 00:00:00pages
222-5issue
2eissn
0008-543Xissn
1097-0142journal_volume
57pub_type
杂志文章相关文献
CANCER文献大全abstract::Mitomycin C (MMC) has been evaluated in combination with several antitumor agents. Full dose response curves were established for all drugs and drug combinations. Synergy was shown with MMC plus either cyclophosphamide (CYC) or methotrexate (MTX). In testing MMC and CYC against P388 leukemia, the combined treatment yi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830215)51:4<600::aid-cncr28205
更新日期:1983-02-15 00:00:00
abstract:BACKGROUND:Occult hepatitis B virus (HBV) infection frequently occurs in patients with HBV surface antigen (HBsAg)-negative chronic liver disease, and much evidence suggests that it is a risk factor for hepatocellular carcinoma (HCC) development. However, to the authors' knowledge, no follow-up study has been performed...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21702
更新日期:2006-03-15 00:00:00
abstract:BACKGROUND:Congenital sacrococcygeal teratoma is the most common germ cell tumor in infants and children. It usually is diagnosed at birth, is benign, and consists of fully differentiated mature tissues. Congenital sacrococcygeal teratomas (SCTs) also may contain immature tissues, most commonly of neural origin. The pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20000815)89:4<932::aid-cncr29>3.
更新日期:2000-08-15 00:00:00
abstract:BACKGROUND:Clear cell tumors of the thyroid gland in general are uncommon. Metastatic renal cell carcinoma (RCC) to the thyroid gland is a rare occurrence but must be considered in the differential diagnosis of a thyroid gland clear cell neoplasm to prevent misclassification, potentially resulting in inappropriate clin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10901
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Nonperioperative strokes are rare yet potentially devastating events for children with central nervous system (CNS) tumors. The incidence of and risk factors for nonperioperative strokes in children with CNS tumors is unknown. METHODS:The authors performed a retrospective review of children from their insti...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract:BACKGROUND:The epidophyllotoxin VM 26 has been shown to have single-agent activity in patients with diffuse aggressive lymphoma. In an attempt to determine its activity in combination with other agents known to be effective in lymphoma, a Phase II trial of a novel chemotherapy regimen was conducted. METHODS:Forty-two ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19930115)71:2<464::aid-cncr28207
更新日期:1993-01-15 00:00:00
abstract:BACKGROUND:The authors hypothesized that insurance payer and race would influence the care and outcomes for patients with breast carcinoma. METHODS:The authors examined treatments and adjusted risk of death (through 1997) for all incident cases of breast carcinoma occurring in Florida in 1994 (n = 11,113) by using sta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001201)89:11<2202::aid-cncr8>3
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:In late reproductive-aged breast cancer survivors, there is a need for real-time biomarkers of postchemotherapy ovarian function. The objective was to determine whether antimullerian hormone (AMH) and inhibin B are such biomarkers. The authors tested whether AMH and inhibin B were impacted by breast cancer t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24746
更新日期:2010-02-01 00:00:00
abstract::Local and systemic toxicities associated with hepatic arterial infusion of human recombinant tumor necrosis factor (rTNF) were studied in healthy adult mongrel dogs. The animals received saline containing human serum albumin with or without rTNF (0.02, 0.2, or 2.0 mg/m2). Arteriograms were made, and blood samples were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890601)63:11<2096::aid-cncr282
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Treatment of localized prostate carcinoma (LPC) using radiotherapy (RT) can induce disturbances in a patient's quality of life (QOL) and urinary and intestinal function. Late symptoms and QOL were evaluated in a randomized trial between RT and deferred treatment (DT). METHODS:Quality of life was evaluated w...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20011215)92:12<3111::aid-cncr101
更新日期:2001-12-15 00:00:00
abstract::A hospital-based case-control study was done to examine the hypothesis that persons with a family history of multiple myeloma (MM) or other cancers are at increased risk of multiple myeloma. Study members were 439 cases of multiple myeloma and 1317 matched controls seen at the Duke University Medical Center. Only 3 ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851015)56:8<2133::aid-cncr2820
更新日期:1985-10-15 00:00:00
abstract:BACKGROUND:Matrix metalloproteinases (MMP) are a gene family of zinc enzymes capable of degrading almost all of the extracellular matrix macromolecules in vivo. Their enzymic activities are believed to be responsible for tumor invasion and metastasis. METHODS:In this study, using peroxidase-antiperoxidase method, mono...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921215)70:12<2747::aid-cncr282
更新日期:1992-12-15 00:00:00
abstract:BACKGROUND:Hispanics now represent a majority of residents in Miami-Dade County, Florida. In this report, the authors present new cancer incidence and mortality data for South Florida's Hispanic men for the period 1990-1998 and compare them with data from a previous report from the 1980s. Periodic updating of cancer in...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract::Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<472::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract::After a series of studies on the linkage of reserpine with breast cancer, both evidence and interpretation appeared to be in conflict. Our case-control survey of long-term, comprehensive records from the Kaiser Foundation Medical Care Program, on 108 hypertensive breast cancer cases and 324 hypertensive controls, matc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<761::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:Although Kaposi sarcoma (KS) initially was described over a century ago, its biology remains enigmatic and conflicting. Whereas the classic type occurs mainly in older men of Mediterranean or Eastern European backgrounds and is not linked to impairment of the host immune response, iatrogenic and human immuno...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Fifty-eight patients with Dukes' C classification of carcinoma of the large bowel were placed on adjuvant immuno- or chemoimmunotherapy with Bacillus calmette guerin (BCG) or combination of 5-fluorouracil (5-FU) plus BCG following primary and definitive surgery, and were followed for up to 21 months. Of twenty-six pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197512)36:6<2421::aid-cncr282036
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND:The current study reports on the significance of cervical smears identified as atypical squamous cells of undetermined significance (ASCUS) in the largest Asian screening population to date. METHODS:From January 1998 to December 1999, 190,000 cervical smears were evaluated by the cervical cytology laborator...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20045
更新日期:2004-04-25 00:00:00
abstract:BACKGROUND:The long-term impact of breast carcinoma and its treatment was assessed in 153 breast carcinoma survivors previously treated on a Phase III randomized trial (Cancer and Leukemia Group B [CALGB 7581]) a median of 20 years after entry to CALGB 7581. METHODS:Survivors were interviewed by telephone using the fo...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.11531
更新日期:2003-08-15 00:00:00
abstract:BACKGROUND:To compare the diagnostic value of thoracoscopic biopsy, fluid cytology, and Abrams needle biopsy, the authors analyzed prospectively the records of 188 patients with malignant pleural mesothelioma examined between 1973 and 1990. Symptoms were pleural effusion in 173 patients, empyema in 1, spontaneous pneum...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19930715)72:2<389::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract::Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891215)64:12<2515::aid-cncr282
更新日期:1989-12-15 00:00:00
abstract:BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25826
更新日期:2011-05-15 00:00:00
abstract:METHODS:Between 1983 and 1989, 42 patients with Stage II, III, and IV, node-negative, squamous cell head and neck cancer were treated with concurrent 5-fluorouracil, cisplatin, and radiation therapy. Two courses of chemotherapy with 30 Gy of concurrent radiation therapy were to be followed in all patients by definitive...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19921201)70:11<2685::aid-cncr282
更新日期:1992-12-01 00:00:00
abstract::The current study determines the prognostic factors after hepatectomy for hepatocellular carcinomas. The 295 patients who underwent hepatectomy from 1973 through 1987 were included for a univariate and a Cox multivariate analysis. The favoring conditions were determined as follows. The essential requirements are (1) t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1104::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract::Amputation is often a component in the treatment of bone tumors such as osteogenic sarcoma, which is most prevalent in the adolescent age group. Adaptation to cancer and loss of a limb requires a significant multidimensional effort. To examine the role of social support systems, 27 adolescents who had undergone amputa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850815)56:4<965::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract:BACKGROUND:Approximately 5-10% of patients with rhabdomyosarcomas (RMS) are diagnosed during the first year of life, and their clinical characteristics have been well documented. However, because RMS rarely occurs during the neonatal period, little is known about neonatal RMS. METHODS:Four patients with neonatal RMS w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010915)92:6<1613::aid-cncr1487
更新日期:2001-09-15 00:00:00
abstract:BACKGROUND:Although cutaneous desmoplastic malignant melanoma (DMM) has been well characterized, those arising from the oral mucosa have been less well defined. METHODS:We evaluated the clinical and pathologic features of three patients with biopsy-proven DMM examined at the North Carolina Baptist Hospital. Routine he...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960801)78:3<383::AID-CNC
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori recently was identified as a risk factor for gastric cancer. Its association with preneoplastic conditions of the stomach, however, is undocumented. METHODS:Gastric biopsy specimens from 245 symptomatic patients were examined for neoplastic and preneoplastic lesions and for gastric H. py...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930115)71:2<297::aid-cncr28207
更新日期:1993-01-15 00:00:00
abstract::A specimen from the small intestine with multiple (three) classic carcinoid tumors and one appendiceal carcinoid tumor displaying argentaffinity, argyrophilia (Grimelius stain), and serotonin and neuron specific enolase immunoreactivity was examined by light microscopy with regard to the tumor cell histopathogenesis. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870715)60:2<201::aid-cncr28206
更新日期:1987-07-15 00:00:00
abstract:BACKGROUND:We investigated p16(INK4A) expression in branchial cleft cysts and its utility in distinguishing branchial cleft cysts from metastatic head and neck squamous cell carcinomas (SCCs) in fine-needle aspiration biopsies (FNABs). METHODS:A study set comprising 41 resections (15 SCC and 26 branchial cleft cysts) ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20001
更新日期:2009-04-25 00:00:00