Abstract:
:Forty-four patients with advanced carcinoma of the head and neck were treated with cyclophosphamide, 400 mg/m2 plus BCNU, 100 mg/m2 day 1 followed by adriamycin 40 mg/m2 day 2, with therapy repeated every 4 weeks. Of 31 evaluable patients, there were 1 complete response, and 10 partial responses (35%). Four of 8 patients without prior chemotherapy had complete or partial responses, as did 7 of 23 patients who had received prior chemotherapy. The mean survival for patients with partial responses was 8.8 months, and for patients with stable disease was 7.8 months. The mean time to progression for patients with partial responses was 5.4 months, and for patients with stable disease was 3.2 months. Granulocytopenia was the dose limiting toxicity, and patients with increasing degrees of myelosuppression appeared to have higher quality responses and longer survival. The ABC treatment program is useful in the palliative management of patients with advanced carcinoma of the head and neck.
journal_name
Cancerjournal_title
Cancerauthors
Presant CA,Ratkin G,Klahr C,Brown Cdoi
10.1002/1097-0142(197911)44:5<1571::aid-cncr282044subject
Has Abstractpub_date
1979-11-01 00:00:00pages
1571-5issue
5eissn
0008-543Xissn
1097-0142journal_volume
44pub_type
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