Abstract:
:Earlier literature suggests a high incidence of multicentricity and bilaterality, with an overall poor prognosis, in patients with invasive lobular carcinoma of the breast. Consequently, there is considerable disagreement regarding appropriate local management of this disease. To determine the influence of invasive lobular histologic findings on local tumor control, disease-free survival, and overall survival, the authors reviewed 60 patients with Stage I and II invasive lobular breast carcinoma treated with local tumor excision and radiation therapy between 1981 and 1987 (mean follow-up, 5.5 years; range, 2.5 to 10 years). The 5-year actuarial risk of locoregional recurrence was 5%, with two of three failures occurring in the regional lymphatics. The mean time to locoregional failure was 28 months. The 5-year actuarial disease-free survival (84%) and overall survival (91%) were comparable to those seen in several large series of similarly treated patients with invasive ductal carcinoma. Contralateral breast cancer occurred at a rate of approximately 0.6% per year. This study and a review of the literature suggest that breast conservation, with local resection and radiation therapy, is appropriate therapy for invasive lobular breast cancer.
journal_name
Cancerjournal_title
Cancerauthors
Poen JC,Tran L,Juillard G,Selch MT,Giuliano A,Silverstein M,Fingerhut A,Lewinsky B,Parker RGdoi
10.1002/1097-0142(19920601)69:11<2789::aid-cncr282subject
Has Abstractpub_date
1992-06-01 00:00:00pages
2789-95issue
11eissn
0008-543Xissn
1097-0142journal_volume
69pub_type
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