Treatment of myelodysplastic syndromes with daily oral idarubicin. A phase I-II study.

abstract：BACKGROUND:Increasingly, the quality of life (QOL) of women diagnosed with breast carcinoma is being studied. However, there is little information regarding long term survivors among ethnic minority women. The purpose of this study was to describe the QOL of long term breast carcinoma survivors (BCS) and to examine the...

journal_title：Cancer

authors： Ashing-Giwa K,Ganz PA,Petersen L

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Fas-expressing cytotoxic T lymphocytes (CTLs) are important antitumor immune effector cells in patients with hepatocellular carcinoma (HCC). The role of transforming growth factor beta 1 (TGF-beta1) in modulating the expression of Fas by CTLs is not known in HCC. The objectives of this study were to characte...

journal_title：Cancer

authors： Yuen MF,Hughes RD,Heneghan MA,Langley PG,Norris S

更新日期：2001-10-15 00:00:00

abstract：:This study examines the interrelationships of depth of penetration, tumor size, and the number of positive nodes in Dukes C colorectal cancer. The results indicated that depth of tumor penetration was related to both tumor size and the number of positive regional lymph nodes. Tumors with positive nodes which failed to...

journal_title：Cancer

authors： Wolmark N,Fisher ER,Wieand HS,Fisher B

更新日期：1984-06-15 00:00:00

abstract：:An in vivo model is described for assessing the antitumor activity of chemotherapeutic agents. Tumors derived from human colon carcinoma cell lines injected into antithymocyte serum (ATS) immunosuppressed mice were used. In this system, both antitumor effects and host toxicity can be quantitated, permitting calculatio...

journal_title：Cancer

authors： Tibbetts LM,Chu MY,Hager JC,Dexter DL,Calabresi P

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:The role of myeloablative chemotherapy in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors (MB/ST-PNET) is controversial, in particular in patients who develop recurrent disease after craniospinal radiotherapy. METHODS:In this retrospective analysis, the authors in...

journal_title：Cancer

authors： Butturini AM,Jacob M,Aguajo J,Vander-Walde NA,Villablanca J,Jubran R,Erdreich-Epstein A,Marachelian A,Dhall G,Finlay JL

更新日期：2009-07-01 00:00:00

abstract：:The reactivity of serum alpha-fetoprotein (AFP) from 20 patients with hepatocellular carcinoma (HCC) with immobilized lentil lectin was examined and found to be significantly greater (39% +/- 18%) than that of the same protein from seven patients with chronic liver disease (CLD, 11.2% +/- 3.3%), seven with fulminant h...

journal_title：Cancer

authors： Du MQ,Hutchinson WL,Johnson PJ,Williams R

更新日期：1991-01-15 00:00:00

abstract：BACKGROUND:Estrogen receptor-alpha (ERalpha) is variably expressed in hepatocellular carcinoma (HCC) and is believed to be correlated with prognosis and survival. Recently, another estrogen receptor (ERbeta) has been identified, but its relevance in liver diseases is unknown. METHODS:The expression of ERbeta in the li...

journal_title：Cancer

authors： Iavarone M,Lampertico P,Seletti C,Francesca Donato M,Ronchi G,del Ninno E,Colombo M

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the bre...

journal_title：Cancer

authors： Dewar JA,Arriagada R,Benhamou S,Benhamou E,Bretel JJ,Pellae-Cosset B,Marin JL,Petit JY,Contesso G,Sarrazin D

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMP) are a gene family of zinc enzymes capable of degrading almost all of the extracellular matrix macromolecules in vivo. Their enzymic activities are believed to be responsible for tumor invasion and metastasis. METHODS:In this study, using peroxidase-antiperoxidase method, mono...

journal_title：Cancer

authors： Shima I,Sasaguri Y,Kusukawa J,Yamana H,Fujita H,Kakegawa T,Morimatsu M

更新日期：1992-12-15 00:00:00

abstract：BACKGROUND:The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule. METHODS:The authors randomly assigned 215 men who h...

journal_title：Cancer

authors： Viani GA,Viana BS,Martin JE,Rossi BT,Zuliani G,Stefano EJ

更新日期：2016-07-01 00:00:00

abstract：:The prolonged administration of bisphosphonates can reduce the frequency of morbid skeletal events in patients with metastatic breast carcinoma or multiple myeloma. The development of more potent bisphosphonates will simplify current therapeutic schemes and could improve the therapeutic effectiveness of bisphosphonate...

journal_title：Cancer

authors： Body JJ

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:Clinical guidelines recommend against routine prostate-specific antigen (PSA) screening for older men and for those with lower life expectancies. The authors of this report examined providers' decision-making regarding discontinuing PSA screening. METHODS:A survey of primary providers from a large, universi...

journal_title：Cancer

authors： Pollack CE,Platz EA,Bhavsar NA,Noronha G,Green GE,Chen S,Carter HB

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Information regarding prognostic factors and survival in elderly women with metastatic breast cancer treated with tamoxifen is limited. METHODS:The data from 4 prospective clinical trials were analyzed, including information on 396 postmenopausal women with advanced breast cancer who received tamoxifen as i...

journal_title：Cancer

authors： Dhodapkar MV,Ingle JN,Cha SS,Mailliard JA,Wieand HS

更新日期：1996-02-15 00:00:00

abstract：:The DNA stemline ploidy was assessed in paraffin-embedded, formalin-fixed primary tumor tissue from 68 patients with nonseminomatous germ cell cancer (NSCGT) clinical Stage I (CS I). Forty-three patients had a single aneuploid (greater than 1C) DNA stemline, whereas 24 patients had multiple aneuploid stemlines. In one...

journal_title：Cancer

authors： Fosså SD,Nesland JM,Waehre H,Amellem O,Pettersen EO

更新日期：1991-04-01 00:00:00

abstract：:"Bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma. The case of a 54-year-old man with 60 such intra-epidermal carcinomas, and a history of arsenic ingestion, is presented. The patient was sensitized to dinitrochlorobenzene ...

journal_title：Cancer

authors： Raaf JH,Krown SE,Pinsky CM,Cunningham-Rundles W,Safai B,Oettgen HF

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:The treatment of metastatic renal cell carcinoma (RCC) with high-dose interleukin-2 (HD IL-2) has resulted in durable tumor regression in a minority of patients. The current study presents the authors' 20-year experience administering this immunotherapeutic agent. METHODS:Patients with metastatic RCC (n = 2...

journal_title：Cancer

authors： Klapper JA,Downey SG,Smith FO,Yang JC,Hughes MS,Kammula US,Sherry RM,Royal RE,Steinberg SM,Rosenberg S

更新日期：2008-07-15 00:00:00

abstract：:Thyroglobulin messenger RNA (mRNA) was located and quantified in tissue sections of differentiated human thyroid cancers by in situ hybridization using cloned complementary DNA probes. The cells of the well-differentiated follicular and papillary forms contained similar levels of thyroglobulin mRNA, corresponding to a...

journal_title：Cancer

authors： Bergé-Lefranc JL,Cartouzou G,De Micco C,Fragu P,Lissitzky S

更新日期：1985-07-15 00:00:00

abstract：BACKGROUND:The incidence of adenocarcinoma of the cervix did not decline in Western countries in the 1970s and 1980s despite the availability and use of cervical cytologic screening. The impact of improved endocervical sampling and better recognition of the cytologic precursors to adenocarcinoma during the 1990s in red...

journal_title：Cancer

authors： Mitchell H,Hocking J,Saville M

更新日期：2003-12-25 00:00:00

abstract：BACKGROUND:The current study was conducted to investigate the diagnostic value of neurologic evaluation for the prediction of intracranial metastases in cancer patients with new or changed headache. METHODS:Between February 1997 and February 2000, general practitioners and specialists referred cancer patients with new...

journal_title：Cancer

authors： Christiaans MH,Kelder JC,Arnoldus EP,Tijssen CC

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) is associated with poor survival. Platinum-based chemotherapy is often a first-line treatment. Pemetrexed has shown single-agent activity in SCCHN and in combination with cisplatin for other tumors. This trial examined the efficacy ...

journal_title：Cancer

authors： Urba S,van Herpen CM,Sahoo TP,Shin DM,Licitra L,Mezei K,Reuter C,Hitt R,Russo F,Chang SC,Hossain AM,Frimodt-Moller B,Koustenis A,Hong RL

更新日期：2012-10-01 00:00:00

abstract：:The possible effect of oral contraceptive (OC) use on the prognosis of established breast cancer was investigated in 154 young women aged 35 and younger. No significant differences were found between the study group of 59 OC users, and the control group of 95 nonusers in age, parity and gravidity, family history of br...

journal_title：Cancer

authors： Rosner D,Lane WW,Perez Brett R

更新日期：1985-04-01 00:00:00

abstract：:During a retrospective case-control study of recent laryngeal cancer patients, several associated factors were studied to determine possible changes in the epidemiology of laryngeal cancer between 1956 and 1974. The large sex difference noted in the early survey (male: female ratio of 14.9:1) diminished considerably i...

journal_title：Cancer

authors： Wynder EL,Covey LS,Mabuchi K,Mushinski M

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:The phosphatidylinositol-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is dysregulated in patients with metastatic renal cell carcinoma (mRCC). Buparlisib is a pan-PI3K inhibitor with activity in advanced solid tumors. The primary objective of the current study was to determine the maximum...

journal_title：Cancer

authors： McKay RR,De Velasco G,Werner L,Bellmunt J,Harshman L,Sweeney C,Rosenberg JE,Hirsch M,Signoretti S,Van Allen EM,Walsh M,Vaishampayan U,McDermott DF,Choueiri TK

更新日期：2016-08-01 00:00:00

abstract：:This overview highlights the use of experimental models in selecting monoclonal antibodies and radiolabels with promise for clinical radioimmunotherapy, discusses some of the experimental therapeutic approaches being studies in these models, and reviews some of the limitations of animal models caused by the allometric...

journal_title：Cancer

authors： Wahl RL

更新日期：1994-02-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) has several potential uses in bone marrow transplantation. Most often IVIG is used to modify cytomegalovirus (CMV) infection or CMV-related interstitial pneumonia. It also is used to modify graft versus host disease (GVHD) and decrease infections other than CMV. Another use is to trea...

journal_title：Cancer

authors： Gale RP,Winston D

更新日期：1991-09-15 00:00:00

abstract：BACKGROUND:The impact of cancer on socioeconomic outcomes is attracting attention as the number of survivors of cancer in young age continues to rise. This study examines economic independence in a national cohort of survivors of cancer at a young age in Norway. METHODS:Through the linkage of several national registri...

journal_title：Cancer

authors： Gunnes MW,Lie RT,Bjørge T,Syse A,Ruud E,Wesenberg F,Moster D

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guideline...

journal_title：Cancer

authors： Shuch B,La Rochelle JC,Klatte T,Riggs SB,Liu W,Kabbinavar FF,Pantuck AJ,Belldegrun AS

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Rural residence has been associated with increased risk of late stage cancer diagnosis, but it is unknown if this is related to lower socioeconomic status (SES) of rural residents or to other factors. This study examined the impacts of SES and urban/rural status on colorectal cancer (CRC) stage at diagnosis ...

journal_title：Cancer

authors： Parikh-Patel A,Bates JH,Campleman S

更新日期：2006-09-01 00:00:00

abstract：:Recent follow-up studies of patients with mammary carcinoma treated with breast-conserving primary radiotherapy identified a triad of pathologic features significantly associated with local treatment failure. These unfavorable characteristics of the primary tumor were: poor or undifferentiated nuclear grade; intraduct...

journal_title：Cancer

authors： Rosen PP,Kinne DW,Lesser M,Hellman S

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Previous studies have reported additional cancers associated with BRCA mutations; however, the type, magnitude of risk, and sex differences remain to be clarified. The purpose of this study was to evaluate the incidence of cancers other than breast and ovarian cancer in known mutation carriers. METHODS:An i...

journal_title：Cancer

authors： Mersch J,Jackson MA,Park M,Nebgen D,Peterson SK,Singletary C,Arun BK,Litton JK

更新日期：2015-01-15 00:00:00