Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma. A clinicopathologic study.

Abstract:

BACKGROUND:Matrix metalloproteinases (MMP) are a gene family of zinc enzymes capable of degrading almost all of the extracellular matrix macromolecules in vivo. Their enzymic activities are believed to be responsible for tumor invasion and metastasis. METHODS:In this study, using peroxidase-antiperoxidase method, monospecific antisera against MMP-1 (tissue collagenase), MMP-2 (type IV collagenase/72-kilodalton [KD] gelatinase), and MMP-3 (stromelysin) were applied to 29 squamous cell carcinomas and normal epithelium of the esophagus to identify cells synthesizing and secreting these enzymes. RESULTS:Immunoreactivity of MMP-1, -2, and -3 was observed in small cancer nests of the deeply invasive or marginal portion of the tumor. Among the 29 patients studied, the presence of at least one MMP was observed in 17 (58.6%). All three enzymes were observed in six (20.6%) patients, MMP-2 and -3 in five (17.2%) patients, only MMP-2 in three (10.3%) patients, and MMP-3 alone in three (10.3%) patients. There was a good correlation among histologic stage and tumor invasion, lymph node metastasis, and MMP expression. In particular, expression of MMP-2 and -3 was closely related to lymph node metastasis and vascular invasion. CONCLUSIONS:These results suggest that MMP, especially MMP-2 and -3, play an important role in tumor invasion and metastasis and that analysis of MMP-2 and -3 production is useful for evaluation of malignant potential in esophageal carcinoma.

journal_name

Cancer

journal_title

Cancer

authors

Shima I,Sasaguri Y,Kusukawa J,Yamana H,Fujita H,Kakegawa T,Morimatsu M

doi

10.1002/1097-0142(19921215)70:12<2747::aid-cncr282

subject

Has Abstract

pub_date

1992-12-15 00:00:00

pages

2747-53

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

70

pub_type

杂志文章

相关文献

CANCER文献大全
  • New diagnostic, staging, and therapeutic aspects of early breast cancer.

    abstract::Many advances have occurred in breast cancer through research and clinical trials. More confidence in new biological consumptions about invasive breast cancer indicate that: (1) details of the primary breast cancer do not control survival; (2) breast-only failures after local excision do not bias against survival; and...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19900201)65:3+<634::aid-cncr2820

    authors: Cady B

    更新日期:1990-02-01 00:00:00

  • Non-Hodgkin's lymphoma of the larynx (stage IE).

    abstract::Four cases of non-Hodgkin's lymphoma (NHL) limited to the larynx are described. All were diffuse, high-grade, B-cell lymphomas of large lymphoid cell type (three centroblastic and one immunoblastic). Immunocytochemistry was performed on three cases; two showed monoclonal cytoplasmic immunoglobulin and one showed monoc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890901)64:5<1123::aid-cncr2820

    authors: Morgan K,MacLennan KA,Narula A,Bradley PJ,Morgan DA

    更新日期:1989-09-01 00:00:00

  • Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma.

    abstract:BACKGROUND:Diagnosis of nasopharyngeal carcinoma (NPC) at an early disease stage is important for successful treatment and improving the outcome of patients. The use of serum protein profiles and a classification tree algorithm were explored to distinguish NPC from noncancer. METHODS:Serum samples were applied to meta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21970

    authors: Ho DW,Yang ZF,Wong BY,Kwong DL,Sham JS,Wei WI,Yuen AP

    更新日期:2006-07-01 00:00:00

  • Correlation between genetic alteration and long-term clinical outcome of patients with oligodendroglial tumors, with identification of a consistent region of deletion on chromosome arm 1p.

    abstract:BACKGROUND:In oligodendroglial tumors, allelic losses on chromosome arms 1p and 19q are not only diagnostic molecular markers but also statistically significant predictors of both chemosensitivity and longer recurrence-free survival. In the current study, the authors attempted to analyze 21 patients genetically and cli...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11322

    authors: Hashimoto N,Murakami M,Takahashi Y,Fujimoto M,Inazawa J,Mineura K

    更新日期:2003-05-01 00:00:00

  • Thymoma and the nephrotic syndrome: a report of a case.

    abstract::A 48-year-old male presented with the nephrotic syndrome 3 years after resection and irradiation of a thymoma. Renal biopsy revealed membranous glomerulonephritis by electron microscopy. IgA, IgG, and C3 deposition were present in the glomerular basement membrane by immunofluorescence. There was no evidence of other a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800115)45:2<387::aid-cncr28204

    authors: Posner MR,Prout MN,Berk S

    更新日期:1980-01-15 00:00:00

  • Prognosis for primary retroperitoneal sarcoma survivors: a conditional survival analysis.

    abstract:BACKGROUND:The AJCC staging system and post-operative nomograms use patient and tumor characteristics to provide prognostic estimates after resection of retroperitoneal sarcoma (RPS). While these variables help to predict survival at the time of diagnosis and resection, the applicability of these prognostic factors to ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26665

    authors: Abbott AM,Habermann EB,Parsons HM,Tuttle T,Al-Refaie W

    更新日期:2012-07-01 00:00:00

  • Racial/ethnic differences in survival rates in a population-based series of men with breast carcinoma.

    abstract:BACKGROUND:A rare occurrence, about 1500 men in the United States develop breast carcinoma each year. Little is known about survival patterns at the population level, particularly about racial/ethnic variation. METHODS:Using data from the Surveillance, Epidemiology, and End Results Program, we examined survival rates ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10521

    authors: O'Malley CD,Prehn AW,Shema SJ,Glaser SL

    更新日期:2002-06-01 00:00:00

  • Body composition in cachexia resulting from malignant and non-malignant diseases.

    abstract::The body composition of 23 patients with cachexia resulting from malignant or benign inflammatory disease was studied. Skinfold thickness and radioisotope tracer measurements enabled us to estimate total body fat, lean body mass, the ratio of fat loss to lean body loss, erythrocyte and plasma volumes, total body water...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801101)46:9<2041::aid-cncr2820

    authors: Watson WS,Sammon AM

    更新日期:1980-11-01 00:00:00

  • Effect of secretin and cholecystokinin-pancreozymin on plasma CEA concentration in patients with pancreatic carcinoma and pancreatitis.

    abstract::Plasma CEA concentration before and after administration of secretin and cholecystokinin-pancreozymin has been determined in 89 patients with neoplastic or inflammatory pancreatric disease and other neoplastic and nonneoplastic disorders. The purpose of the study was to expore the specificity and sensitivity of such a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197906)43:6<2465::aid-cncr282043

    authors: Lindstedt G,Lundberg PA,Rolny P

    更新日期:1979-06-01 00:00:00

  • Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients.

    abstract::A series of consecutive trials were undertaken to determine whether higher doses of intravenous metoclopramide and combinations of metoclopramide, dexamethasone, and diphenhydramine would improve antiemetic control or decrease treatment-related side effects in patients receiving cisplatin at 120 mg/m2. Metoclopramide ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19850201)55:3<527::aid-cncr28205

    authors: Kris MG,Gralla RJ,Tyson LB,Clark RA,Kelsen DP,Reilly LK,Groshen S,Bosl GJ,Kalman LA

    更新日期:1985-02-01 00:00:00

  • Atypical glandular cells of undetermined significance: clinically significant lesions and means of patient follow-up.

    abstract:BACKGROUND:The clinical significance of atypical glandular cells of undetermined significance (AGUS) remains poorly understood, and patient management is not standardized. The authors evaluated the rate, qualification, and follow-up (FU) findings of AGUS patients. METHODS:Computerized records from the authors' institu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Soofer SB,Sidawy MK

    更新日期:2000-08-25 00:00:00

  • Mucin core protein expression in extrahepatic bile duct carcinoma is associated with metastases to the liver and poor prognosis.

    abstract:BACKGROUND:Curative resection does not guarantee long term survival for the patient with extrahepatic bile duct carcinoma because of the possibility of metastases to the liver (LM). Expression of mucin core protein-1 (MUC1), sialyl-Le(x), and sialosyl-Tn in bile duct carcinoma was determined and compared with LM and pr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19991115)86:10<1966::aid-c

    authors: Takao S,Uchikura K,Yonezawa S,Shinchi H,Aikou T

    更新日期:1999-11-15 00:00:00

  • The importance of the stable category for chemotherapy treated patients with advanced and relapsing prostate cancer.

    abstract::Categories of objective response to chemotherapy for 460 advanced relapsing prostate cancer patients evaluated in the initial first four randomized clinical trials of the National Prostatic Cancer Project were compared by survival and other patient and disease characteristics. The response criteria for stable were sho...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19801201)46:11<2393::aid-cncr282

    authors: Slack NH,Mittelman A,Brady MF,Murphy GP

    更新日期:1980-12-01 00:00:00

  • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early-stage breast cancer: results of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial efficacy and safety update ana

    abstract:BACKGROUND:The first analysis of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial (median follow-up, 33 months) demonstrated that in adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer, anastrozole was superior to tamoxifen in terms of disease-free survival (DFS), time to r...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.11745

    authors: Baum M,Buzdar A,Cuzick J,Forbes J,Houghton J,Howell A,Sahmoud T,ATAC (Arimidex, Tamoxifen Alone or in Combination) Trialists' Group.

    更新日期:2003-11-01 00:00:00

  • Dietary vitamins A and C and lung cancer risk in Louisiana.

    abstract::The authors describe the results of a hospital-based incident case-control study of lung cancer conducted in a high-risk region of southern Louisiana from January 1979 through April 1982. Dietary intake of carotene, retinol, and vitamin C was estimated from food frequency questionnaires administered to 1253 cases and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881115)62:10<2267::aid-cncr282

    authors: Fontham ET,Pickle LW,Haenszel W,Correa P,Lin YP,Falk RT

    更新日期:1988-11-15 00:00:00

  • Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis.

    abstract::The difficulties encountered in establishing a diagnosis of a malignant peritoneal mesothelioma are emphasized in a patient who developed the lesion 16 years after radiation therapy for a seminoma of the testis. Historically, histologically, electron microscopically, and by microincineration, there was no evidence of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197909)44:3<914::aid-cncr2820440

    authors: Stock RJ,Fu YS,Carter JR

    更新日期:1979-09-01 00:00:00

  • Prognostic indicators of colon tumors. The Gastrointestinal Tumor Study Group experience.

    abstract::This study sought to replicate and expand findings reported by the National Surgical Adjuvant Breast and Bowel Project (NSABP) on prognostic factors in resectable colon cancer. Mantel-Haenszel tests and the Cox model were used to analyze prognostic significance and effect of primary disease symptoms and tumor location...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860501)57:9<1866::aid-cncr2820

    authors: Steinberg SM,Barkin JS,Kaplan RS,Stablein DM

    更新日期:1986-05-01 00:00:00

  • Clinical evaluation of specific gamma-GTP isoenzyme in patients with hepatocellular carcinoma.

    abstract::The authors evaluated specific gamma-GTP isoenzyme (specific gamma-GTP) found in sera of patients with hepatocellular carcinoma (HCC). In addition to band II and II' which had been reported in our previous publication, band I' also had a high specificity for HCC. One or more of these bands were detectable in 109 (55%)...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830115)51:2<327::aid-cncr28205

    authors: Sawabu N,Nakagen M,Ozaki K,Wakabayashi T,Toya D,Hattori N,Ishii M

    更新日期:1983-01-15 00:00:00

  • Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resista

    abstract:BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20571

    authors: Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

    更新日期:2004-10-15 00:00:00

  • Mesothelioma following Wilms' tumor in childhood.

    abstract::A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840715)54:2<367::aid-cncr28205

    authors: Antman KH,Ruxer RL Jr,Aisner J,Vawter G

    更新日期:1984-07-15 00:00:00

  • Results with chemotherapy comprised of cyclophosphamide, doxorubicin, vincristine, and prednisone followed by radiotherapy with or without prechemotherapy surgical debulking for patients with bulky, aggressive lymphoma.

    abstract:BACKGROUND:The authors performed a case-control analysis of local control, progression free survival, and overall survival in patients with Stage I-II aggressive lymphomas measuring > or = 7 cm in greatest dimension who were treated initially with or without surgical debulking: All patients then received cyclophosphami...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10260

    authors: Wilder RB,Romaguera JE,Tucker SL,Ha CS,Hess MA,Cabanillas F,Cox JD

    更新日期:2002-02-01 00:00:00

  • A randomized, active-control, pilot trial of front-loaded dosing regimens of darbepoetin-alfa for the treatment of patients with anemia during chemotherapy for malignant disease.

    abstract:BACKGROUND:Anemia in patients receiving chemotherapy can be ameliorated with recombinant human erythropoietin (rHuEPO), which is administered one to three times per week. Darbepoetin alpha, a new erythropoietic agent, has longer serum residence time, allowing it to be administered less frequently. METHODS:Patients (n ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.11186

    authors: Glaspy JA,Jadeja JS,Justice G,Fleishman A,Rossi G,Colowick AB

    更新日期:2003-03-01 00:00:00

  • Parametric survival analysis of gastric cancer patients.

    abstract::A total of 1026 patients with gastric cancer was followed up for five years after surgery and classified into different groups according to surgeons' assessment of nodal involvement, serosal invasion, peritoneal spread, and hepatic metastasis. The survival of each group was studied by parametric analysis, using the lo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801215)46:12<2709::aid-cncr282

    authors: Maetani S,Tobe T,Hirakawa A,Kashiwara S,Kuramoto S

    更新日期:1980-12-15 00:00:00

  • Diffuse malignant epithelial mesotheliomas of the peritoneum in women: a clinicopathologic study of 25 patients.

    abstract:BACKGROUND:The behavior of diffuse peritoneal mesotheliomas in women and the possible relation between tumor morphology and outcome are uncertain. Reported survival has ranged from < 1 month to > 14 years, and a previous study found that tumor morphology could not be used reliably for predicting outcome. The authors ex...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10209

    authors: Kerrigan SA,Turnnir RT,Clement PB,Young RH,Churg A

    更新日期:2002-01-15 00:00:00

  • Risk factors associated with earlier age of onset in familial pancreatic carcinoma.

    abstract:BACKGROUND:An estimated 5-10% of all pancreatic adenocarcinomas have a hereditary association. The objective of the current study was to characterize the clinical and pathologic features of familial pancreatic carcinoma and to determine potential differences in demographics, risk factors, and outcomes between familial ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20700

    authors: James TA,Sheldon DG,Rajput A,Kuvshinoff BW,Javle MM,Nava HR,Smith JL,Gibbs JF

    更新日期:2004-12-15 00:00:00

  • Restoring platinum sensitivity in recurrent ovarian cancer by extending the platinum-free interval: Myth or reality?

    abstract::The platinum-free interval is the most important predictive factor of a response to subsequent lines of chemotherapy and the most important prognostic factor for progression-free and overall survival in patients with recurrent epithelial ovarian cancer. A nonplatinum regimen is generally considered the most appropriat...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.30830

    authors: Tomao F,D'Incalci M,Biagioli E,Peccatori FA,Colombo N

    更新日期:2017-09-15 00:00:00

  • Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors.

    abstract:BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25255

    authors: Rausch SM,Clark MM,Patten C,Liu H,Felten S,Li Y,Sloan J,Yang P

    更新日期:2010-09-01 00:00:00

  • Pulmonary toxicity of mitomycin.

    abstract::Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800115)45:2<236::aid-cncr28204

    authors: Buzdar AU,Legha SS,Luna MA,Tashima CK,Hortobagyi GN,Blumenschein GR

    更新日期:1980-01-15 00:00:00

  • Fanconi anemia. Oxymetholone hepatic tumors, and chromosome aberrations associated with leukemic transition.

    abstract::Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800915)46:6<1401::aid-cncr2820

    authors: Obeid DA,Hill FG,Harnden D,Mann JR,Wood BS

    更新日期:1980-09-15 00:00:00

  • Using data to effectively manage a national screening program.

    abstract::The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) of the Centers for Disease Control and Prevention (CDC) is implemented through cooperative agreements with state health departments, US territories, and tribal health organizations (grantees). Grantees typically contract with clinicians and othe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28821

    authors: Yancy B,Royalty JE,Marroulis S,Mattingly C,Benard VB,DeGroff A

    更新日期:2014-08-15 00:00:00