Abstract:
BACKGROUND:Diagnosis of nasopharyngeal carcinoma (NPC) at an early disease stage is important for successful treatment and improving the outcome of patients. The use of serum protein profiles and a classification tree algorithm were explored to distinguish NPC from noncancer. METHODS:Serum samples were applied to metal affinity protein chips to generate mass spectra by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). Protein peak identification and clustering were performed using the Biomarker Wizard software. Proteomic spectra of serum samples from 50 NPC patients and 54 noncancer controls were used as a training set and a classification tree with 6 distinct protein masses was generated by using Biomarker Pattern software. The validity of the classification tree was then challenged with a blind test set including another 20 NPC patients and 25 noncancer controls. RESULTS:The software identified an average of 93 mass peaks/spectrum and 6 of the identified peaks were used to construct the classification tree. The classification tree correctly determined 83% (123 of 149) of the test samples with 83% (58 of 70) of the NPC samples and 82% (65 of 79) of the noncancer samples. In a combination of the serum protein profiles with Epstein-Barr (EBV) nuclear antigen 1 (EBNA1 IgA) test, the diagnostic sensitivity and specificity were increased to 99% and 96%, respectively. CONCLUSIONS:The results suggest that SELDI-TOF-MS serum protein profiles could discriminate NPC from noncancer. The combination of serum protein profiles with an EBV antibody serology test could further improve the accuracy of NPC screening.
journal_name
Cancerjournal_title
Cancerauthors
Ho DW,Yang ZF,Wong BY,Kwong DL,Sham JS,Wei WI,Yuen APdoi
10.1002/cncr.21970subject
Has Abstractpub_date
2006-07-01 00:00:00pages
99-107issue
1eissn
0008-543Xissn
1097-0142journal_volume
107pub_type
杂志文章相关文献
CANCER文献大全abstract::This paper discusses the imaging methods available for the detection and diagnosis of colon cancer, concentrating on endoscopy and barium radiology. Effective utilization of these two methods may be facilitated by using flexible sigmoidoscopy to direct further investigation. There is a need for educational efforts to ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930615)71:12+<4198::aid-cncr28
更新日期:1993-06-15 00:00:00
abstract::A patient with metastatic islet cell carcinoma of the pancreas, recurrent peptic ulcer disease, and hypergastrinemia (Zollinger-Ellison syndrome) developed symptomatic hypercalcemia and renal insufficiency; she was treated with streptozotocin after parathyroidectomy failed to control her hypercalcemia. Shortly after s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197612)38:6<2217::aid-cncr282038
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:The Akt/mammalian target of rapamycin (mTOR) pathway mediates cell survival and proliferation and contributes to tumor progression. Soft tissue leiomyosarcoma continues to show poor prognosis, and little is known about its mechanisms of tumor progression. Here the authors investigated the significance of act...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26448
更新日期:2012-03-15 00:00:00
abstract::The case of a 71-year-old woman who developed generalized weakness, lymphadenopathy, and a skin rash during methyldopa therapy is described. The prompt disappearance of symptoms following the discontinuation of the drug implicates it in the initial triggering of the abnormal lymphoid proliferation. Shortly thereafter,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197811)42:5<2322::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Controlled-release (CR) morphine tablets have become routine therapy in the management of cancer pain. Compared with immediate-release (IR) morphine, this formulation provides the benefit of dosing every 12 hours. METHODS:This study reviewed the 10 published, well controlled, repeated-dose, comparative stud...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19980615)82:12<2299::aid-c
更新日期:1998-06-15 00:00:00
abstract:BACKGROUND:Previous studies have suggested an excess cancer risk in patients with carcinoid tumors. This association was reexamined using truly population-based data. METHODS:By means of data from the Danish Cancer Registry all carcinoid tumors diagnosed in Denmark between 1978 and 1989 were identified. All patients w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950701)76:1<106::aid-cncr28207
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Papanicolaou smear sensitivity for cervical adenocarcinoma (CVCA) is not well established. Also uncertain are the relative contributions to falsely negative diagnoses of sampling, screening, and interpretive errors. METHODS:Papanicolaou smears were identified from all patients at our institutions with biops...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-02-25 00:00:00
abstract:BACKGROUND:The role of resectional surgery in patients with advanced stages of gallbladder carcinoma has not been fully defined. It is generally believed that the survival depends on the stage of the disease, rather than on the treatment option. METHODS:Seventeen selected risk factors were analyzed using univariate an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951001)76:7<1145::aid-cncr2820
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:After surgical resection, the residual, invasive glioblastoma (GBM) cells give rise to a recurrent tumor, which, in 96% of patients, arises adjacent to the resection margin. METHODS:In this study, the authors prospectively enrolled 25 patients with GBM who underwent gross total resection followed by adjuvan...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.23624
更新日期:2008-08-15 00:00:00
abstract::Methotrexate with citrovorum rescue (MTX-CF) was administered as primary treatment in 106 patients with gestational trophoblastic disease (GTD). Ninety-six patients (90.6%) achieved complete remission with MTX-CF and 77 of these patients (80.2%) required only one course of MTX-CF to attain remission. MTX-CF induced su...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821115)50:10<2024::aid-cncr282
更新日期:1982-11-15 00:00:00
abstract:BACKGROUND:Insulin-like growth factor I (IGF-I) is a potent mitogen for breast cancer cells. The majority of IGF-I in plasma is bound to IGF binding proteins (IGFBPs), which modulate the biologic effects of IGF-I. METHODS:Plasma concentrations of IGF-I, IGFBP-I, and IGFBP-3 were compared between 40 postmenopausal brea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940715)74:2<618::aid-cncr28207
更新日期:1994-07-15 00:00:00
abstract::The presentation, growth patterns, and response to therapy of 11 consecutive children with choroid plexus carcinomas were analyzed, and the results were compared with the outcome reported in other series. Patients were a median of 26 months of age at diagnosis. Two patients had thalamic tumors, one had a posterior fos...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920115)69:2<580::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract::Pain management often is difficult in patients with bone metastases. Metastatic disease represents >40% of oncologic practice, and >70% of patients with metastatic disease have uncontrolled cancer-related pain. Significant morbidity caused by pathologic fracture and spinal cord compression can result from untreated bo...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8+<1628::aid-c
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:Although cutaneous desmoplastic malignant melanoma (DMM) has been well characterized, those arising from the oral mucosa have been less well defined. METHODS:We evaluated the clinical and pathologic features of three patients with biopsy-proven DMM examined at the North Carolina Baptist Hospital. Routine he...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960801)78:3<383::AID-CNC
更新日期:1996-08-01 00:00:00
abstract::Surgical removal of bulky metastases of non-seminomatous germ-cell testicular cancer has been advocated as an adjuvant to chemotherapy in patients whose disease probably is too extensive to be cured by chemotherapy or surgery alone. However, in 8 of our patients, cytoreductive surgery was followed by a sudden and dram...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:6<1498::aid-cncr2820
更新日期:1980-03-15 00:00:00
abstract:BACKGROUND:Many experienced oncologists have encountered patients with proven non-small cell lung cancer (NCLC) who received modest doses of palliative radiotherapy (RT) and who unexpectedly survived for > 5 years; some were apparently cured. We used a very large prospective database to estimate the frequency of this p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21704
更新日期:2006-03-01 00:00:00
abstract::The predisposition of preexisting cirrhotic metabolic liver disease to the development of hepatocellular carcinoma is well established. However, the association between glycogenoses (a form of noncirrhotic metabolic liver disease) and the formation of benign and malignant liver tumors is less well known. The sixth cas...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920315)69:6<1320::aid-cncr2820
更新日期:1992-03-15 00:00:00
abstract::Canada is a westernized, market-economy nation with a publicly funded health care and cancer control system and has health indices reflective of a high-resource economy. Provision of health services is in accord with the Canada Health Act and is implemented through federal, provincial, and territorial relations wherei...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26053
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:To the authors' knowledge there are few data that correlate the expression of the epidermal growth factor receptor (EGFR) with the outcome of patients who have breast carcinoma and are treated with anthracycline chemotherapy. METHODS:Pretreatment tumor tissue samples were available from 82 patients who had ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21217
更新日期:2005-08-15 00:00:00
abstract::One hundred eighty-four patients with advanced measurable colorectal cancer not previously treated with chemotherapy were entered into a prospective randomized clinical trial by the Mid-Atlantic Oncology Program (MAOP) to assess the value of weekly cisplatin (20 mg/m2) when added to a protracted schedule of 5-fluorour...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/1097-0142(19910101)67:1<14::aid-cncr282067
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Microwave ablation has recently been developed as a safe and effective treatment for a variety of tumors. The authors evaluated the safety and efficacy of computed tomography (CT)-guided percutaneous microwave ablation of adrenal malignant tumors. METHODS:Nine patients between 41 and 83 years of age (averag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26128
更新日期:2011-11-15 00:00:00
abstract:BACKGROUND:Soft tissue sarcomas (STSs) are heterogeneous neoplasms that have variable clinical outcome. Several clinical parameters and few molecular markers, including Ki-67 proliferative index, have been shown to correlate with patient prognosis. To the authors' knowledge, no definitive report exists to identify one ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010815)92:4<869::aid-cncr1395>
更新日期:2001-08-15 00:00:00
abstract:BACKGROUND:Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy allows the detailed imaging and FNA not only of both intramural and extramural structures and lesions of the gastrointestinal (GI) tract but also of various intraabdominal organs. Thus, EUS-FNA biopsy offers a novel opportunity to evaluate ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20498
更新日期:2004-10-25 00:00:00
abstract:BACKGROUND:Human papillomaviruses (HPV) have been implicated strongly in the pathogenesis of human squamous cell carcinomas, especially of anogenital carcinomas. Some pathologic changes of the esophagus may be one of the candidates for HPV etiology, but the role of HPV infections in the carcinogenesis of the esophagus ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921101)70:9<2234::aid-cncr2820
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Primary and metastatic malignancies that originate in the sinonasal tract are rare and histologically diverse. The role of fine-needle aspiration biopsy (FNAB) and the cytomorphologic features of these tumors have not been specifically addressed. METHODS:The authors reviewed 22 cytology cases (20 FNABs, 1 s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10956
更新日期:2003-04-25 00:00:00
abstract:BACKGROUND:Estimates of the fecal occult blood test (FOBT) (Hemoccult II) sensitivity differed widely between screening trials and led to divergent conclusions on the effects of FOBT screening. We used microsimulation modeling to estimate a preclinical colorectal cancer (CRC) duration and sensitivity for unrehydrated F...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24256
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Radiologic Diagnostic Oncology Group 5 is a multicenter clinical trial designed to evaluate fine-needle aspiration (FNA) of nonpalpable breast lesions performed by multiple operators using the same protocol. METHODS:Four hundred and nineteen women with mammographically detected nonpalpable breast lesions we...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(sici)1097-0142(19980215)82:4<679::aid-cnc
更新日期:1998-02-15 00:00:00
abstract::The records of 51 patients with esophageal carcinoma were reviewed. Twenty-two patients underwent attempted curative resection with a mean survival of 7.7 months. Twenty patients underwent primary radiotherapy (mean survival, 4.3 months). Nine patients received palliative therapy alone (mean survival, 2.8 months). Sur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840901)54:5<918::aid-cncr28205
更新日期:1984-09-01 00:00:00
abstract::Sixteen cases of clear cell adenocarcinoma of the cervix and vagina in young women were studied by electron microscopy and the observations were compared with the light microscopic appearance. Ultrastructurally, the neoplastic cells were found to be of the same basic type, regardless of whether light microscopy disclo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800401)45:7<1615::aid-cncr2820
更新日期:1980-04-01 00:00:00
abstract::A patient with a 17-year course of metastatic lobular carcinoma of the breast is described who developed large numbers of circulating carcinoma cells which were easily detectable in several routine peripheral blood smears shortly before death. This rare complication of carcinoma has been called "carcinocythemia." Carc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197712)40:6<3107::aid-cncr282040
更新日期:1977-12-01 00:00:00