Abstract:
BACKGROUND:Radiologic Diagnostic Oncology Group 5 is a multicenter clinical trial designed to evaluate fine-needle aspiration (FNA) of nonpalpable breast lesions performed by multiple operators using the same protocol. METHODS:Four hundred and nineteen women with mammographically detected nonpalpable breast lesions were enrolled on the trial at 18 institutions. Group A institutions randomized women to stereotactically guided FNA (SFNA) followed by stereotactically guided core needle biopsy (SCNB), or SCNB only. Group B institutions randomized women to SFNA and SCNB, SCNB, or ultrasonographically guided FNA followed by ultrasonographically guided core needle biopsy (USCNB), or USCNB only. A total of 377 women were eligible for analysis. RESULTS:FNA yielded 128 insufficient samples for the 377 patients (33.95%; 95% confidence interval, 29.2-38.7%). The rate of insufficient samples varied by type of lesion with calcified lesions associated with a significantly higher rate of insufficient sampling than masses (P < 0.001). The radiologist's level of suspicion of the lesion was not a statistically significant predictor of insufficient samples for mass lesions, but was a predictor for calcified lesions. For the 336 lesions for which histologic information was available, insufficient samples occurred in significantly more benign than malignant lesions. CONCLUSIONS:The high rate of insufficient samples for FNA of nonpalpable breast lesions in this multicenter trial makes its use impractical in this setting. Because of this factor, the study was terminated early.
journal_name
Cancerjournal_title
Cancerauthors
Pisano ED,Fajardo LL,Tsimikas J,Sneige N,Frable WJ,Gatsonis CA,Evans WP,Tocino I,McNeil BJdoi
10.1002/(sici)1097-0142(19980215)82:4<679::aid-cncsubject
Has Abstractpub_date
1998-02-15 00:00:00pages
679-88issue
4eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19980215)82:4<679::AID-CNCjournal_volume
82pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
CANCER文献大全abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970425)81:2<122::aid-cnc
更新日期:1997-04-25 00:00:00
abstract:BACKGROUND:Radiation therapy plays a major role in the management of patients with either locally recurrent or metastatic carcinoma of the prostate. RESULTS:In 23 patients with isolated postprostatectomy local recurrences treated with doses of 60-65 Gy, 17 (74%) had tumor control, and 45% survived relapse-free for 5 y...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19930201)71:3+<1110::aid-cncr282
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess prostate carcinoma detection and discrimination of benign from malignant prostate tissue with contrast-enhanced ultrasonography. METHODS:In all, 301 subjects referred for prostate biopsy were evaluated with contrast-enhanced sonography using continuous harmonic imagin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21440
更新日期:2005-12-01 00:00:00
abstract::Transcriptional dysregulation induced by disease-defining genetic alterations of proteins in transcriptional machinery is a key feature of cancers. Mediator complex subunit 12 (MED12) is the central architectural subunit in the kinase module of Mediator, a large transcriptional regulatory complex that controls essenti...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.32672
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Current adjuvant hormone therapy in postmenopausal women with breast cancer is debatable between upfront aromatase inhibitors (AIs) and sequential treatment with tamoxifen. A major concern is the higher rate of early recurrences observed with sequential treatment. The authors conducted a retrospective analys...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22667
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (CRC). beta-catenin up-regulates c-Myc and cyclin D1, which antagonize the association of the cyclin-dependent kinase (Cdk) inhibitor, p27(kip1), with Cdk2, thus allowing cell cycle ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10986
更新日期:2002-12-15 00:00:00
abstract::The cytologic results of 34 fine-needle aspiration (FNA) biopsies of the central nervous system (CNS) are reported. There were 31 intraoperative biopsies performed at the time of craniotomy. All the cases were diagnosed using direct smear preparations stained with Papanicolaou and Diff-Quik (Harleco, NJ) stains. The s...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860901)58:5<1117::aid-cncr2820
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:Amplification of erb-B2 and myc shows prognostic value in patients with operable breast cancer. Amplification is usually detected in tumor samples remaining after pathologic work-up, preventing the examination of small tumors. METHODS:Tumor imprints that contained low numbers of contaminating normal cells w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950601)75:11<2681::aid-cncr282
更新日期:1995-06-01 00:00:00
abstract::Multifocal osteosarcoma with unique patho-biological features in a 23-year old white male is reported. The natural history and classification of multiple osteosarcomas are reviewed. A proposal is presented for evaluation of the multicentric origin in future cases. ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197911)44:5<1897::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::Reflected ultrasound scanning (echography) is rapidly developing into a prime tool for tumor diagnosis, outlining, and detection. The principles of echographic diagnosis of neoplasms, the accepted uses in detection and diagnosis, as well as some of the principles of internal and contour patterns are discussed. Echogra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197601)37:1+<496::aid-cncr282037
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated an association between a diagnosis of cancer and the risk of suicide; however, they failed to account for psychiatric care before a cancer diagnosis, which may confound this relationship. The objective of this study was to assess the effect of a cancer diagnosis on the risk...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32146
更新日期:2019-08-15 00:00:00
abstract::Forty-five immunocompetent patients with solid tumors were immunized with BCG, PPD, and tumor cells. The methods were practical, but the morbidity was significant, including painful draining ulcerations at vaccine sites, possible enhancement of tumor growth in three patients, and the discovery at autopsy of systemic t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<131::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Childhood cancer survivors are at risk for cardiovascular disease (CVD) because of intensive cancer therapies often accompanied by an unhealthy lifestyle. This study was aimed at 1) describing modifiable CVD risk factors in survivors and 2) investigating the association between different aspects of physical ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33351
更新日期:2021-01-06 00:00:00
abstract::One-hundred and fifty-one adults with acute non-lymphocytic leukemia (ANLL) were entered into an Eastern Cooperative Oncology Group protocol (EST-1473) comparing twice daily cytosine arabinoside and thioguanine (AT) with weekly cyclophosphamide, cytosine arabinoside, and methotrexate (CAM) for remission induction. Of ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19800115)45:2<224::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract:BACKGROUND:: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24559
更新日期:2009-11-01 00:00:00
abstract::Three cases of carcinoid tumor arising in the trachea are reported and contrasted with carcinoids arising in bronchi and carcinoids in general. Only eleven other documented examples of tracheal carcinoids are found in the English literature. The true prevalence of carcinoids primary in the trachea cannot be accurately...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197812)42:6<2870::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the levels of 15-lipoxygenase 1 (15-LOX-1) and 15-LOX-2 as well as their metabolites 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) are significantly reduced in smokers with non-small cell lung carcinoma (NSCLC). Furthermore,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29547
更新日期:2015-09-01 00:00:00
abstract::Carcinomas of the pancreas with giant cells are not rare, but those containing osteoclast-like tumor cells are quite unusual. This report documents a pancreatic neoplasm comprising both easily recognizable well-differentiated adenocarcinoma and osteoclast-like tumor. The literature on the "osteoclastoma" of the pancre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811101)48:9<2022::aid-cncr2820
更新日期:1981-11-01 00:00:00
abstract:BACKGROUND:Current techniques to define gastric neoplasia are limited but molecular genetic signatures can categorize tumors and provide biological rationale for predicting clinical behavior. We identified three gene signatures: Chromogranin A (CgA), MAGE-D2 (adhesion), and MTA1 (metastasis) that define gastrointestina...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21758
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:The authors evaluated the effects of taxol, a microtubular inhibitor, as a possible radiation sensitizer on the human leukemic cell line (HL-60). Taxol acts as a mitotic inhibitor, blocking cells in the G2M-phase of the cell cycle. The differential radiation sensitivity of cells in various phases of the cell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3774::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Validation of the prognostic indices for the recurrence-free interval of patients with parotid carcinoma, the development of which was described in a previous report, is needed to be confident of their generalizability and justified prospective use. METHODS:The Dutch Cooperative Group on Head and Neck Cance...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11254
更新日期:2003-03-15 00:00:00
abstract::The diagnosis of brain metastasis from prostate carcinoma is rarely made antemortem, and has previously been reported only in patients with known extensive metastatic disease of long duration. A case of adenocarcinoma of the prostate presenting as a brain metastasis is described. Current concepts of metastatic spread ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841015)54:8<1723::aid-cncr2820
更新日期:1984-10-15 00:00:00
abstract:BACKGROUND:The malignant biological behavior of small-sized lung adenocarcinomas remains obscure, although understanding this feature is important for selecting appropriate treatment. In the current study, the authors evaluated malignancy grades of small adenocarcinomas using fluorodeoxyglucose-positron emission tomogr...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.25244
更新日期:2010-07-01 00:00:00
abstract::A 69-year-old man with metastatic islet cell carcinoma was treated with streptozotocin and achieved excellent tumor regression. Sixty-seven grams of streptozotocin were given over 28 months. After completion of streptozotocin therapy, the patient had progressive leukopenia. Thirteen months after discontinuation of str...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810415)47:8<1963::aid-cncr2820
更新日期:1981-04-15 00:00:00
abstract::Five hundred and sixty-six patients with either Stage III or IV Hodgkin's disease were prospectively randomized to test whether CCNU and/or vinblastine are more effective than mechlorethamine and/or vincristine with procarbazine and prednisone. The combination of CCNU, vinblastine, procarbazine, and prednisone (CVPP) ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19800815)46:4<654::aid-cncr28204
更新日期:1980-08-15 00:00:00
abstract::The metabolism of 5-fluorouracil (5-FU) was studied in biopsy specimens of primary colorectal cancer and healthy colonic mucosa obtained from previously untreated patients immediately after surgical removal. The conversion of 5-FU to anabolites was measured under saturating substrate (5-FU) and cosubstrate concentrati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<1903::aid-cncr2820
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25255
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Cisplatin is one of the single drugs that has shown the best documented effect in treating patients with locally recurrent or metastatic urothelial cancer. To the authors' knowledge, the effect of the combination of different platinum analogues in treating transitional cell carcinoma has not been evaluated p...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19951115)76:10<1797::aid-cncr282
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:It has been previously observed that patients with head and neck squamous cell carcinoma or with laryngeal leucoplakia present a significant reduction in plasma folate levels. The current Phase IIA pilot study assessed the effectiveness of folic acid as a chemopreventive agent in patients affected by glottic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22003
更新日期:2006-07-15 00:00:00
abstract:BACKGROUND:Population-based studies suggest that, because of inequalities in treatment, black women with localized endometrial cancer have shorter survival compared with white women. The objective of the current investigation was to determine whether there is a racial disparity in outcome between black patients and whi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23717
更新日期:2008-09-15 00:00:00