Experimental radioimmunotherapy. A brief overview.

abstract：BACKGROUND:Through this study, the authors sought to investigate the biologic and immunologic effects of preoperative trastuzumab in patients with ductal carcinoma in situ (DCIS) of the breast. METHODS:Patients with DCIS were enrolled in this open-label phase 2 trial and tested for HER2. Trastuzumab was given by intra...

journal_title：Cancer

authors： Kuerer HM,Buzdar AU,Mittendorf EA,Esteva FJ,Lucci A,Vence LM,Radvanyi L,Meric-Bernstam F,Hunt KK,Symmans WF

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The influence of various clinicopathologic features on survival of patients with papillary thyroid carcinoma has been examined. In particular, histologic grade, which was obtained by a combined assessment of nuclear atypia, tumor necrosis, and vascular invasion (VAN score) was studied. According to this, his...

journal_title：Cancer

authors： Akslen LA

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) ...

journal_title：Cancer

authors： Thomas SM,Malvar J,Tran H,Shows J,Freyer DR

更新日期：2018-03-01 00:00:00

abstract：:From 1974 to 1983, simple and radical nephrectomies were performed at the Chaim Sheba Medical Center (Tel Hashomer, Israel) for renal cell carcinoma. The authors reviewed 109 cases that were followed for a period ranging from 5 to 14 years. Simple nephrectomy was performed in 55 patients, and 54 patients underwent rad...

journal_title：Cancer

authors： Ramon J,Goldwasser B,Raviv G,Jonas P,Many M

更新日期：1991-05-15 00:00:00

abstract：:A case of primary leptomeningeal B-cell lymphoma in an 8-year-old, previously healthy child is described. The child was found to have hypogammaglobulinemia, and the Epstein-Barr virus genome was identified in cultured tumor cells despite blood serology being negative for the virus. The patient was treated with cycloph...

journal_title：Cancer

authors： Hayani A,Venger BH,Rouah E,Laurent JP,Mahoney DH,McClain KL

更新日期：1990-10-15 00:00:00

abstract：:The development of monoclonal antibodies has led to renewed interest in the use of antibodies to treat malignant disease. Unfortunately, treatment with unmodified antibodies has been disappointing. Therapy with unmodified antibodies has been limited by the failure of host effector mechanisms to eliminate antibody-coat...

journal_title：Cancer

authors： Badger CC,Bernstein ID

更新日期：1986-07-15 00:00:00

abstract：:Granulocyte (PMN) directional locomotion (migration) in vitro and in vivo, resting nitroblue tetrazolium (NBT)-reduction and adherence to nylon wool of polymorphonuclear neutrophils (PMN) were assayed in 7 patients with Hodgkin's disease (HD) and in 11 patients with non-Hodgkin's lymphoma (NHL) prior to therapy. In mo...

journal_title：Cancer

authors： Von Fliedner V,Salvatori V,Higby DJ,Stutzman L,Park BH

更新日期：1980-02-01 00:00:00

abstract：:This study evaluates residual disease in 28 B-cell chronic lymphocytic leukemia (B-CLL) patients who obtained a clinicohematologic remission after intensive chemotherapy. Sixteen of 28 patients (57%) showed a normal number of circulating B-lymphocytes, as demonstrated by the low percentage of mouse rosette-forming cel...

journal_title：Cancer

authors： Brugiatelli M,Callea V,Morabito F,Oliva B,Francia Di Celle P,Fierro MT,Neri A,Foa R

更新日期：1989-05-15 00:00:00

abstract：BACKGROUND:Failure to detect metastasis to para-aortic nodes in patients with locally advanced cervical cancer leads to suboptimal treatment. No previous studies have prospectively compared positron emission tomography (PET)/computed tomography (CT) with laparoscopic extraperitoneal staging in the evaluation of para-ao...

journal_title：Cancer

authors： Ramirez PT,Jhingran A,Macapinlac HA,Euscher ED,Munsell MF,Coleman RL,Soliman PT,Schmeler KM,Frumovitz M,Ramondetta LM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Endocrine therapy resistance is a major cause of distant recurrence (DR) in hormone receptor-positive breast cancer. This study evaluated differences in survival after DR in patients treated with different adjuvant endocrine therapy regimens in the Breast International Group (BIG) 1-98 trial. METHODS:BIG 1-...

journal_title：Cancer

authors： Leone JP,Cole BF,Regan MM,Thürlimann B,Coates AS,Rabaglio M,Giobbie-Hurder A,Gelber RD,Ejlertsen B,Harvey VJ,Neven P,Láng I,Bonnefoi H,Wardley A,Goldhirsch A,Di Leo A,Colleoni M,Vaz-Luis I,Lin NU

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. METHODS:The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to iden...

journal_title：Cancer

authors： Fletcher SA,Cole AP,Lu C,Marchese M,Krimphove MJ,Friedlander DF,Mossanen M,Kilbridge KL,Kibel AS,Trinh QD

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:After surgical resection, the residual, invasive glioblastoma (GBM) cells give rise to a recurrent tumor, which, in 96% of patients, arises adjacent to the resection margin. METHODS:In this study, the authors prospectively enrolled 25 patients with GBM who underwent gross total resection followed by adjuvan...

journal_title：Cancer

authors： Mangiola A,de Bonis P,Maira G,Balducci M,Sica G,Lama G,Lauriola L,Anile C

更新日期：2008-08-15 00:00:00

abstract：:Thirteen patients with a variety of advanced gynecologic malignancies were administered BCG via the dorsal lymphatics of the lower extremity in addition to standard accepted forms of therapy. Prolonged febrile courses, lymphangitis and suppurative adenitis were observed along the lymphatic pathway of the injected lowe...

journal_title：Cancer

authors： Mangan C,Jeglum KA,Sedlacek TV,Giuntoli RL,Wheeler JE,Rubin E,Mikuta JJ

更新日期：1977-12-01 00:00:00

abstract：:Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...

journal_title：Cancer

authors： Jönsson PE,Agrup G,Arnbjörnsson E,Hafström L,Rorsman H

更新日期：1980-01-15 00:00:00

abstract：:A solitary tumor which by light microscopy was calssified as a neurofibroma was found by electron microscopic study to be composed of parallel, elongate cells with collagen rich intervening matrix. The cells showed thin, polar cytoplasmic processes which extended long distances, frequent junctional complexes between c...

journal_title：Cancer

authors： Lazarus SS,Trombetta LD

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:Activating mutations in RAS are frequently present in patients with acute myeloid leukemia (AML), but their overall prognostic impact is not clear. METHODS:A retrospective analysis was performed to establish the clinical characteristics of patients with RAS-mutated (RAS(mut) ) AML, to analyze their outcome ...

journal_title：Cancer

authors： Kadia TM,Kantarjian H,Kornblau S,Borthakur G,Faderl S,Freireich EJ,Luthra R,Garcia-Manero G,Pierce S,Cortes J,Ravandi F

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive funct...

journal_title：Cancer

authors： Sherman AM,Jaeckle K,Meyers CA

更新日期：2002-09-15 00:00:00

abstract：:To remove regionally recurrent cancer of the rectum completely, more radical extensive resections were attempted than the conventional ones in 35 patients. Twenty-two patients underwent total pelvic exenteration. In 23, sacral resection was done, combined with other procedures including excision of the entire circumfe...

journal_title：Cancer

authors： Maetani S,Nishikawa T,Iijima Y,Tobe T,Kotoura Y,Shikata J,Yamamura T

更新日期：1992-06-15 00:00:00

abstract：:This study concerns 75 patients with squamous cell carcinoma of the oral cavity who were patients at the Gustave-Roussy Institute between December 1966 and July 1973. These patients were divided into two groups. The first group was comprised of 39 patients who underwent elective radical neck dissection; nodal involvem...

journal_title：Cancer

authors： Vandenbrouck C,Sancho-Garnier H,Chassagne D,Saravane D,Cachin Y,Micheau C

更新日期：1980-07-15 00:00:00

abstract：:Eight hundred sixty-five patients with a microscopically curative resection for carcinoma of the lung were accepted for study, none of whom were excluded from analysis. Adjuvant therapy was randomly assigned about the tenth to 14th postoperative day; 432 patients (treated) were to receive CCNU and hydroxyurea for one ...

journal_title：Cancer

authors： Shields TW,Higgins GA Jr,Humphrey EW,Matthews MJ,Keehn RJ

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Benign and malignant pancreatic mucinous tumors differ in proliferative activity, production of tumor markers, and expression of growth factors. DNA ploidy is a useful index of aggressiveness and poor survival in ductal adenocarcinoma, but has not been studied in pancreatic cystic tumors. METHODS:The DNA pl...

journal_title：Cancer

authors： Southern JF,Warshaw AL,Lewandrowski KB

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-po...

journal_title：Cancer

authors： Malm IJ,Fan CJ,Yin LX,Li DX,Koch WM,Gourin CG,Pitman KT,Richmon JD,Westra WH,Kang H,Quon H,Eisele DW,Fakhry C

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Despite the characteristic histopathologic appearance of alveolar soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogenetic analysis of ASPS is limited to eight cases so far because of the extreme rarity of this disease. METHODS:The authors document a cytogenetic study of a primary case of...

journal_title：Cancer

authors： Joyama S,Ueda T,Shimizu K,Kudawara I,Mano M,Funai H,Takemura K,Yoshikawa H

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:The current study was conducted to evaluate severe mucocutaneous toxicity during treatment with hydroxyurea (HU) in a large cohort of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). METHODS:Among 993 consecutive patients newly diagnosed with MPN at 4 centers in Rome betwee...

journal_title：Cancer

authors： Latagliata R,Spadea A,Cedrone M,Di Giandomenico J,De Muro M,Villivà N,Breccia M,Anaclerico B,Porrini R,Spirito F,Rago A,Avvisati G,Alimena G,Montanaro M,Andriani A,Gruppo Laziale SMPC Ph1 neg.

更新日期：2012-01-15 00:00:00

abstract：:The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. Thes...

journal_title：Cancer

authors： Brooks WH,Roszman TL,Rogers AS

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:Neovascularization reportedly is correlated with metastasis, recurrence, and prognosis in some types of tumors. Microvessel quantification in so-called "hot spots" has been studied extensively as the only factor reflecting angiogenesis in various malignant tumors. The objective of this report was to evaluate...

journal_title：Cancer

authors： Pavlopoulos PM,Konstantinidou AE,Agapitos E,Kavantzas N,Nikolopoulou P,Davaris P

更新日期：1998-11-15 00:00:00

abstract：:Sequential corrected creatinine clearance (CCC) evaluations were obtained in 30 patients treated with intra-arterial and/or intravenous cis-diamminedichloroplatinum-II (CDP). The dose was 150 mg/M2 administered with mannitol diuresis at 2 to 3 weekly intervals. Four hundred fifty-three courses were administered (range...

journal_title：Cancer

authors： Jaffe N,Keifer R 3rd,Robertson R,Cangir A,Wang A

更新日期：1987-05-01 00:00:00

abstract：:Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases ...

journal_title：Cancer

authors： Kanbour AI,Stock RJ

更新日期：1978-08-01 00:00:00

abstract：:Fifty patients with non resectable and/or inoperable bronchogenic carcinoma were entered into a feasibility study of cisplatin (CDDP) given in continuous infusion with concurrent radiation therapy. The radiation therapy regimen consisted of 2 Gy given 5 days a week in the first 3 and last 2 weeks of a 7-week split cou...

journal_title：Cancer

authors： Bedini AV,Tavecchio L,Milani F,Gramaglia A,Spreafico C,Marchianò A,Ravasi G

更新日期：1991-01-15 00:00:00

abstract：BACKGROUND:The authors purpose in this study was to clarify the difference in terms of clinicopathologic features between gastric cancer (GC) with high numbers of DNA methylated genes and CpG island methylator phenotype (CIMP)-positive GC as originally defined. METHODS:We analyzed DNA methylation of 12 tumor-related g...

journal_title：Cancer

authors： Oue N,Mitani Y,Motoshita J,Matsumura S,Yoshida K,Kuniyasu H,Nakayama H,Yasui W

更新日期：2006-03-15 00:00:00