Abstract:
BACKGROUND:Despite the characteristic histopathologic appearance of alveolar soft-part sarcoma (ASPS), its histogenesis remains unclear, and cytogenetic analysis of ASPS is limited to eight cases so far because of the extreme rarity of this disease. METHODS:The authors document a cytogenetic study of a primary case of ASPS in which a modern spectral karyotyping technique was used. RESULTS:A standard cytogenetic analysis of the primary tumor cells with G-banding revealed 46,XY, add(17)(q25) in 23 of 25 metaphases analyzed. This structural rearrangement of chromosome 17, involving band q25, was also present in 5 of 8 ASPS cases in the literature. Moreover, with the spectral karyotyping technique, the additional part of the long arm of chromosome 17 in the current case was found to originate from chromosome X, resulting in a final tumor karyotype of 46, XY, add(17)(q25).ish der(17)t(X;17) (p11.2;q25)(wcpX+). CONCLUSIONS:This case report documents a clonal chromosome abnormality of der(17)t(X;17)(p11.2;q25) in ASPS. The results of the current study indicate that further molecular analyses focused on 17q25 and Xp11.2 are of interest and could help to elucidate the pathogenesis of ASPS.
journal_name
Cancerjournal_title
Cancerauthors
Joyama S,Ueda T,Shimizu K,Kudawara I,Mano M,Funai H,Takemura K,Yoshikawa Hsubject
Has Abstractpub_date
1999-10-01 00:00:00pages
1246-50issue
7eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19991001)86:7<1246::AID-CNjournal_volume
86pub_type
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