Recurrence of Hodgkin's disease after indium-111 and yttrium-90 labeled antiferritin administration.

Abstract:

BACKGROUND:Indium-111 labeled antiferritin targets 95% of all Hodgkin's disease lesions with a diameter of 1 cm or more. Subsequent treatment with yttrium-90 labeled antiferritin secures a high response rate in patients with recurrent Hodgkin's disease. METHODS:A total of 87 patients were entered on one of three different yttrium-90 labeled antiferritin protocols. Recurrences after yttrium-90 treatment were analyzed. Nine patients were retreated with involved external beam radiation fields, selected with the help of indium-111 labeled antiferritin. RESULTS:In single-agent yttrium-90 antiferritin studies, a response rate of more than 60% was found, with an average response duration of 6 months. One-third of the patients had recurrences in previously uninvolved areas. Repeat indium antiferritin scintigraphy allowed for the selection of new radiation fields for recurrences. In-field disease control was obtained for a median of 8 months, but new recurrences in new areas occurred. Chemotherapy or radiation therapy given immediately before antiferritin decreased tumor targeting with indium-111 labeled antiferritin. CONCLUSIONS:Recurrences after radiolabeled antiferritin treatment are not due to radioresistant Hodgkin's disease. In contrast, Hodgkin's disease less than 1 cm in diameter is not targeted and not controlled by radiolabeled antiferritin. New multimodality regimens with a higher therapeutic ratio are needed for treatment of Hodgkin's disease with curative intent. Radiolabeled antiferritin can be incorporated in such regimens to secure better control of bulky Hodgkin's disease (>1 cm in diameter), but it should be given before chemotherapy or radiation therapy.

journal_name

Cancer

journal_title

Cancer

authors

Vriesendorp HM,Quadri SM,Andersson BS,Wyllie CT,Dicke KA

doi

10.1002/(sici)1097-0142(19971215)80:12+<2721::aid-

subject

Has Abstract

pub_date

1997-12-15 00:00:00

pages

2721-7

issue

12 Suppl

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19971215)80:12+<2721::AID-

journal_volume

80

pub_type

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