Possible effects of non-HLA antibodies in common typing sera on HLA antigen frequency data in leukemia.

Abstract:

:Selective adsorption of several common "monospecific" HLA typing sera with HLA typed platelets, purified B lymphocytes, cultured lymphoid cells, or lymphocytes from patients with active chronic lymphocytic leukemia demonstrated that many of these sera contain antibodies to non-HLA antigens. Antibodies were detected to antigens present on peripheral blood B-lymphocytes, cultured lymphoid cells and leukemic cells from patients with both myelocytic and lymphocytic forms of leukemia but absent from T-lymphocytes and platelets. Since these kinds of antibodies appear to be present in a large proportion of common HLA typing sera, caution should be used in interpreting all data related to HLA antigen expression in leukemia.

journal_name

Cancer

journal_title

Cancer

authors

Pollack MS,DuBois D

doi

10.1002/1097-0142(197706)39:6<2348::aid-cncr282039

subject

Has Abstract

pub_date

1977-06-01 00:00:00

pages

2348-54

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

39

pub_type

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