Abstract:
BACKGROUND:Children receiving immunosuppressive treatment for cancer are at high risk for invasive pneumococcal disease. The 13-valent pneumococcal conjugate vaccine (PCV13) can prevent pneumococcal disease in healthy children; however, there is an absence of literature regarding the benefit of PCV13 in immunocompromised children with cancer. METHODS:A prospective, open-label cohort study recruited children between ages 1 and 18 years who were receiving active immunosuppressive therapy (AIT) or were within 12 months after completing immunosuppressive therapy (CIT). Blood samples were taken before and 4 weeks after the administration of single-dose PCV13. Serotype-specific immunoglobulin G antibody titers were measured, and titers ≥0.35 μg/mL were considered protective. Solicited side effects were recorded in a 7-day diary after vaccination. RESULTS:Eighty-five children were recruited. At baseline, ≤50% had protective antibody titers against Streptococcus pneumoniae for 10 serotypes in the AIT group and for 8 serotypes in the CIT group. Postvaccination, ≥70% had protective antibody titers for 9 and 11 serotypes in the AIT and CIT groups, respectively. Both groups had comparable responses to PCV7 serotypes, whereas a significantly higher proportion in the CIT group achieved protective antibody titers to PCV13 serotypes. There was a low rate of serious adverse events (3.5%). CONCLUSIONS:A single-dose of PCV13 is safe and immunogenic in children diagnosed with cancer. All children who are receiving therapy for cancer should receive a single dose of PCV13 as soon as possible after diagnosis, regardless of prior PCV exposure. The current data support the recommendation for an additional dose of PCV13 after the completion of immunosuppressive therapy to provide additional protection against invasive pneumococcal disease. Cancer 2017;123:4215-4223. © 2017 American Cancer Society.
journal_name
Cancerjournal_title
Cancerauthors
Hung TY,Kotecha RS,Blyth CC,Steed SK,Thornton RB,Ryan AL,Cole CH,Richmond PCdoi
10.1002/cncr.30764subject
Has Abstractpub_date
2017-11-01 00:00:00pages
4215-4223issue
21eissn
0008-543Xissn
1097-0142journal_volume
123pub_type
杂志文章相关文献
CANCER文献大全abstract::Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C. In one patient, karyotypic abnormalities (-5, 7q-) typical of a therapy induced malignancy were associated with rapid progr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900101)65:1<23::aid-cncr282065
更新日期:1990-01-01 00:00:00
abstract::Surgery is the most effective treatment for thyroid cancer; however, in some subsets of patients, the role of radiotherapy (RT) is important. The main indication for external-beam RT is incomplete surgery. When neoplastic tissue is left behind at operation, RT must be considered, but only if an experienced surgeon fee...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850501)55:9+<2062::aid-cncr282
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:To compare the diagnostic value of thoracoscopic biopsy, fluid cytology, and Abrams needle biopsy, the authors analyzed prospectively the records of 188 patients with malignant pleural mesothelioma examined between 1973 and 1990. Symptoms were pleural effusion in 173 patients, empyema in 1, spontaneous pneum...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19930715)72:2<389::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract::Transcriptional dysregulation induced by disease-defining genetic alterations of proteins in transcriptional machinery is a key feature of cancers. Mediator complex subunit 12 (MED12) is the central architectural subunit in the kinase module of Mediator, a large transcriptional regulatory complex that controls essenti...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.32672
更新日期:2020-03-01 00:00:00
abstract::The authors report the accuracy of mammographically guided fine-needle aspiration (FNA) for the diagnosis of nonpalpable breast lesions in a series of 71 patients. Each mammographically guided FNA was immediately followed by hookwire localization and open biopsy. Seven malignancies were identified cytologically, but t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911101)68:9<2007::aid-cncr2820
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:The Women's Health Initiative randomized clinical trial reported that menopausal hormone therapy increases lung cancer mortality risk. If this is true, use of anti-estrogens should be associated with decreased lung cancer mortality risk. The authors compared lung cancer incidence and mortality among breast c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25638
更新日期:2011-03-15 00:00:00
abstract:BACKGROUND:Extragonadal germ cell tumors (EGGCT) are uncommon, occur primarily in the mediastinum and retroperitoneum, and have been noted to have variable response rates to cisplatin-based chemotherapy regimens. METHODS:The Southwest Oncology Group (SWOG) has completed a prospective trial of combination chemotherapy ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19930415)71:8<2631::aid-cncr2820
更新日期:1993-04-15 00:00:00
abstract::Immunomorphologic methods were utilized to localize adenosine deaminase (ADA) in extrathymic benign lymphoid tissues and B-cell lymphomas. In reactive lymph nodes, tonsils and appendix, germinal centers displayed strong ADA-positive nuclear staining in small cleaved lymphocytes and weak nuclear and/or cytoplasmic stai...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840101)53:1<70::aid-cncr282053
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-04-15 00:00:00
abstract:BACKGROUND:Human pancreatic ribonuclease (RNase 1) is a pancreatic enzyme that is present at high levels in the serum of most patients with pancreatic adenocarcinoma. For this reason, the authors studied its patterns of expression at the single-cell level in pancreatic adenocarcinoma tissues by immunohistochemical anal...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-15 00:00:00
abstract::Levamisole, used in vitro at therapeutic concentrations, was found able to restore the defective Fc-receptor activity of cancer patient neutrophils. In addition, the drug prevented the inhibition of normal neutrophils Fc-receptor function by cancer patient sera. The neutrophil Fc-receptor function was also restored in...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850415)55:8<1668::aid-cncr2820
更新日期:1985-04-15 00:00:00
abstract:BACKGROUND:Failure to obtain the requisite follow-up of patients with abnormal mammograms may delay cancer diagnosis and impact outcome. Up to 20% of women do not receive timely recommended follow-up. The current study tested the accuracy of the linkage of payer claims and clinical data to identify the appropriate trea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22808
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:In cholangiocarcinoma, no established method of analysis of lymph node metastasis has been reported with respect to the surgical outcome. METHODS:The authors retrospectively examined the pattern of lymph node metastasis and the surgical outcome with reference to the International Union Against Cancer (UICC)...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::Flow cytometric measurements were done on 51 ovarian carcinoma specimens collected from consecutive patients in a prospective study. The ploidy status was related to the course of the disease. The tumors from 26 (52%) of 50 evaluable patients had DNA aneuploidy. Patients with diploid tumors were more often considered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880301)61:5<971::aid-cncr28206
更新日期:1988-03-01 00:00:00
abstract::The histories of 121 Stage II melanoma patients were reviewed to determine the value of monitoring serum LDH in postoperative follow-up examinations. Charts of 58 Stage III patients who had autopsies at UCLA also were reviewed to define the relationship between an elevated LDH and liver metastases. The sensitivity and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830301)51:5<840::aid-cncr28205
更新日期:1983-03-01 00:00:00
abstract::A 44-year-old patient with histologically proven bilateral ulcerated lymph node metastases from a carcinoma of the penis was treated by sequenced combined chemotherapy and radical irradiation. Methotrexate and bleomycin were administered at weekly intervals for 5 weeks, followed by radiation with a split-course coning...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841015)54:8<1720::aid-cncr2820
更新日期:1984-10-15 00:00:00
abstract::A 69-year-old man with metastatic islet cell carcinoma was treated with streptozotocin and achieved excellent tumor regression. Sixty-seven grams of streptozotocin were given over 28 months. After completion of streptozotocin therapy, the patient had progressive leukopenia. Thirteen months after discontinuation of str...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810415)47:8<1963::aid-cncr2820
更新日期:1981-04-15 00:00:00
abstract:BACKGROUND:Tamoxifen has been used in the treatment of patients with metastatic malignant melanoma either as a single agent or, more commonly, in combination with other chemotherapeutic agents. The aim of the current study was to summarize the available clinical evidence on the role of the tamoxifen in different combin...
journal_title:Cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/cncr.11644
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Colonoscopy is the most widely used colorectal cancer (CRC) screening test in the United States. Through the detection and removal of potentially precancerous polyps, it can prevent CRC. However, CRC screening remains low among adults who are recommended for screening. The New Hampshire Colorectal Cancer Scr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31864
更新日期:2019-02-15 00:00:00
abstract::Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) with other drugs, in conjunction with a peripheral blood stem cell autograft (PBSCT), for treating 26 children with acute leukemia or lymphoma associated wit...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910401)67:7<1830::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract::The diagnosis and grading of chondrosarcoma of bone is best established by a complementary study of its cytology, as observed in smeared preparations, and of its tissue structure and relationship to the host bone, as observed in histologic sections. Smeared preparations demonstrate the cytologic features of chondrosar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800201)45:3<582::aid-cncr28204
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:It has previously been shown that heparanase-1 (HPR1), an endoglycosidase, is up-regulated in pancreatic carcinoma. The purpose of this study was to test whether serum HPR1 levels in pancreatic carcinoma patients are elevated, and whether higher serum HPR1 levels are associated with a shortened survival. ME...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21648
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:The purpose of the current study was to determine the frequency of 'probably benign' interpretations at breast magnetic resonance (MR) imaging screening of high-risk women and the frequency of subsequent malignancy in these women. METHODS:The authors performed a retrospective review of the records of 367 as...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11491
更新日期:2003-07-15 00:00:00
abstract::The European Organization for Research on Treatment of Cancer (EORTC) trial 20781, concerning osteosarcoma of the limbs is reported. After definitive treatment of the primary tumor with amputation or irradiation, adjuvant treatment was given, randomized into either 9 months of chemotherapy according to a modified Rose...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19880301)61:5<1024::aid-cncr2820
更新日期:1988-03-01 00:00:00
abstract::In a clinical trial, 42 patients with abdominal Burkitt's lymphoma (BL) were treated with a combination regimen, code-named CVA, consisting of cyclophosphamide (CTX), vincristine, and cystosine arabinoside. In addition, intrathecal methotrexate (i.t. MTX) was administered as prophylaxis against subsequent central nerv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4<1410::aid-cncr282040
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:4'-0-tetrahydropyranyladriamycin (Pirarubicin, Meiji Seika (USA) Inc., New York, NY) may be less toxic than doxorubicin. METHODS:A Phase II trial of Pirarubicin was done in 26 patients who had not previously had chemotherapy and who had measurable and incurable head and neck carcinoma. All patients received...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19920915)70:6<1591::aid-cncr2820
更新日期:1992-09-15 00:00:00
abstract:BACKGROUND:There is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim-based analysis for determining patterns of care and guiding possible treatment recommendations. METHODS:Medicare beneficiaries who were 65 ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30989
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Tumor volume in radical prostatectomies can be determined by several different techniques and appears to predict clinical progression. Greatest tumor dimension and area are easily obtained measures that are both correlated with tumor volume. The authors sought to determine whether greatest tumor dimension an...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-08-15 00:00:00
abstract::The glucocorticoid receptor (GR) quantitation by a whole-cell assay and/or cytosol technique and the in vitro sensitivity to steroids have been assessed in peripheral blood cells from normal donors and patients with chronic lymphatic leukemia (CLL), acute lymphoblastic leukemia (ALL), lymphosarcoma cell leukemia (LSCL...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820215)49:4<623::aid-cncr28204
更新日期:1982-02-15 00:00:00
abstract::The clinical course of 29 patients with idiopathic refractory sideroblastic anemia studied by us was reviewed. Four patients developed acute leukemia. We were able to find 27 out of 268 cases of idiopathic refractory sideroblastic anemia reported in the literature which terminated in acute leukemia. Nine of these were...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197908)44:2<724::aid-cncr2820440
更新日期:1979-08-01 00:00:00