Use of tamoxifen in the treatment of malignant melanoma.

Abstract:

BACKGROUND:Tamoxifen has been used in the treatment of patients with metastatic malignant melanoma either as a single agent or, more commonly, in combination with other chemotherapeutic agents. The aim of the current study was to summarize the available clinical evidence on the role of the tamoxifen in different combination chemotherapy regimens because clinical studies including tamoxifen have produced inconclusive results. METHODS:The authors designed a systematic review and metaanalysis of published randomized controlled trials to assess the benefit of tamoxifen added to various single-agent or multiagent chemotherapy or biochemotherapy regimens. RESULTS:Six randomized trials met the inclusion criteria and were analyzed. These 6 trials involved a combined total of 912 patients. Of this number, 455 patients were randomized to receive tamoxifen added to chemotherapy or biochemotherapy regimens and 457 were randomized to receive chemotherapy or biochemotherapy without tamoxifen. The overall response rate was not improved significantly by the addition of tamoxifen to the chemotherapy regimen (odds ratio [OR], 1.16; 95% confidence interval [CI], 0.75-1.82; test for overall effect: P = 0.14). The results were not statistically significant for complete response (OR, 0.64; 95% CI, 0.33-1.25; test for overall effect: P = 0.19). CONCLUSIONS:The current metaanalysis demonstrated that tamoxifen does not improve the overall response rate, complete response rate, or survival rate when administered along with combined chemotherapy regimens. Currently, the strength of evidence does not support the use of tamoxifen in combination with other systemic chemotherapy for the treatment of metastatic melanoma.

journal_name

Cancer

journal_title

Cancer

authors

Lens MB,Reiman T,Husain AF

doi

10.1002/cncr.11644

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1355-61

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

98

pub_type

杂志文章,meta分析,评审

相关文献

CANCER文献大全
  • Occupation and lung cancer risk. An analysis by histologic subtypes.

    abstract::The relationships between cigarette smoking, occupational exposures, dietary vitamin A and lung cancer is explored in a case-control study. The study is based on 1002 primary lung cancers among white men and 1119 white male controls between 35 and 79 years of age admitted to Roswell Park Memorial Institute from 1957 t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850815)56:4<910::aid-cncr28205

    authors: Vena JE,Byers TE,Cookfair D,Swanson M

    更新日期:1985-08-15 00:00:00

  • Anaerobic liver abscess and intrahepatic metastases: a case report and review of the literature.

    abstract::A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in wh...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197802)41:2<682::aid-cncr2820410

    authors: Trump DL,Fahnestock R,Cloutier CT,Dickman MD

    更新日期:1978-02-01 00:00:00

  • Juvenile xanthogranuloma. Clinicopathologic analysis and immunohistochemical study of 57 patients.

    abstract::Fifty-seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820

    authors: Sonoda T,Hashimoto H,Enjoji M

    更新日期:1985-11-01 00:00:00

  • A prospective randomized trial of thalidomide with topotecan compared with topotecan alone in women with recurrent epithelial ovarian carcinoma.

    abstract:BACKGROUND:Thalidomide is an antiangiogenic agent with immune modulating potential. The objective of this study was to determine response rates among women who were treated for recurrent ovarian cancer using topotecan with or without thalidomide. METHODS:Women were enrolled in this multicenter, prospective, randomized...

    journal_title:Cancer

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/cncr.23164

    authors: Downs LS Jr,Judson PL,Argenta PA,Ghebre R,Geller MA,Bliss RL,Boente MP,Nahhas WA,Abu-Ghazaleh SZ,Chen MD,Carson LF

    更新日期:2008-01-15 00:00:00

  • Defining a molecular phenotype for benign and malignant parathyroid tumors.

    abstract:BACKGROUND:It is frequently difficult to establish histologically whether a parathyroid tumor is a parathyroid carcinoma, parathyromatosis, or an atypical adenoma. The authors asked whether these tumors have a distinctive molecular profile, whether benign tumors could be distinguished from malignant tumors, and whether...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24037

    authors: Fernandez-Ranvier GG,Khanafshar E,Tacha D,Wong M,Kebebew E,Duh QY,Clark OH

    更新日期:2009-01-15 00:00:00

  • Thin-needle aspiration biopsy: the diagnosis of head and neck tumors revisited.

    abstract::Results of 567 thin-needle aspiration biopsies of head and neck lesions are reviewed. Cases included lymph nodes, salivary glands, thyroid, soft tissue and bone lesions. For the entire series, 17 patients had unsatisfactory aspirations. There were 12 false negative reports and 4 false positive reports, rates of 2.1% a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197904)43:4<1541::aid-cncr282043

    authors: Frable WJ,Frable MA

    更新日期:1979-04-01 00:00:00

  • Toll-like receptor-4 signaling in mantle cell lymphoma: effects on tumor growth and immune evasion.

    abstract:BACKGROUND:Mantle cell lymphoma (MCL) is an incurable B-cell malignancy, and patients with this disease have the poorest prognosis among all patients with B-cell lymphomas. The signaling pathways that trigger MCL escape from immune surveillance are unclear. Because Toll-like receptors (TLRs) initiate innate and adaptiv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27792

    authors: Wang L,Zhao Y,Qian J,Sun L,Lu Y,Li H,Li Y,Yang J,Cai Z,Yi Q

    更新日期:2013-02-15 00:00:00

  • 9-Aminocamptothecin by 72-hour continuous intravenous infusion is inactive in the treatment of patients with 5-fluorouracil-refractory colorectal carcinoma.

    abstract:BACKGROUND:9-Aminocamptothecin (9AC) and its parent compound, camptothecin, have shown outstanding preclinical activity against colorectal carcinoma. Irinotecan (CPT-11), another camptothecin derivative, has demonstrated clinical activity in patients with 5-fluorouracil (5-FU)-refractory colorectal carcinoma. METHODS:...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19971101)80:9<1727::aid-cn

    authors: Saltz LB,Kemeny NE,Tong W,Harrison J,Berkery R,Kelsen DP

    更新日期:1997-11-01 00:00:00

  • Prognostic factors in early-stage uterine sarcoma. A Gynecologic Oncology Group study.

    abstract:BACKGROUND:A clinicopathologic evaluation of clinical Stage I and II uterine sarcoma was done by the Gynecologic Oncology Group from 1979-1988. METHODS:After all eligibility criteria were met, 453 cases were evaluable and analyzed for prognostic factors. RESULTS:Of the 301 mixed mesodermal tumors (MMT), 167 were homo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820710440

    authors: Major FJ,Blessing JA,Silverberg SG,Morrow CP,Creasman WT,Currie JL,Yordan E,Brady MF

    更新日期:1993-02-15 00:00:00

  • The quantitative relationship of carcinoembryonic antigen to tumor cells of different organs.

    abstract::Carcinoembryonic antigen (CEA) was measured in extracts of cell suspensions from tumors of the colon, stomach, breast, lung and kidney. Cell suspensions were also obtained from normal tissue surrounding the primary tumors. The number of neoplastic cells in each cell suspension was determined by cytologic criteria. Hig...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197708)40:2<808::aid-cncr2820400

    authors: MacSween JM,Anderson GH

    更新日期:1977-08-01 00:00:00

  • Diagnostic utility of bilateral bone marrow examination: significance of morphologic and ancillary technique study in malignancy.

    abstract:BACKGROUND:To retrospectively evaluate the significance of morphologic examination and ancillary studies performed on bilateral bone marrow biopsy specimens, 1864 bone marrow samples were studied. METHODS:Bilateral bone marrow biopsy specimens included 883 specimens that were evaluated for involvement by non-Hodgkin l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10364

    authors: Wang J,Weiss LM,Chang KL,Slovak ML,Gaal K,Forman SJ,Arber DA

    更新日期:2002-03-01 00:00:00

  • The long-term effect of cisplatin on renal function.

    abstract::The long-term effect of cisplatin on renal function was studied in a follow-up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/m2 (range, 275-650 mg/m2). Prehydration with isotonic saline secured diures...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861115)58:10<2214::aid-cncr282

    authors: Fjeldborg P,Sørensen J,Helkjaer PE

    更新日期:1986-11-15 00:00:00

  • Taxol in advanced, hormone-refractory carcinoma of the prostate. A phase II trial of the Eastern Cooperative Oncology Group.

    abstract:BACKGROUND:Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone-refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. METHODS:Twenty-three patients with ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/1097-0142(19931015)72:8<2457::aid-cncr2820

    authors: Roth BJ,Yeap BY,Wilding G,Kasimis B,McLeod D,Loehrer PJ

    更新日期:1993-10-15 00:00:00

  • Screening young adult cancer survivors with the PROMIS Depression Short Form (PROMIS-D-SF): Comparison with a structured clinical diagnostic interview.

    abstract:BACKGROUND:The current study was conducted to evaluate the Patient-Reported Outcomes Measurement Information System Depression Short Form (PROMIS-D-SF) as a screening measure for young adult cancer survivors (YACS) compared with a structured diagnostic interview. METHODS:A total of 249 YACS (aged 18-40 years) complete...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32689

    authors: Recklitis CJ,Blackmon JE,Chang G

    更新日期:2020-04-01 00:00:00

  • IgM-producing gastric plasmacytoma.

    abstract::A case of gastric plasmacytoma is reported in an 81-year-old woman. Immunofluorescent and immunoelectrophoretic studies showed that the tumor cells produced IgM-lambda molecules, whereas no monoclonal immunoglobulin could be detected both in the serum and in the urine. Of more than 60 reported cases of gastric plasmac...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(1984)54:4<638::aid-cncr282054040

    authors: Funakoshi N,Kanoh T,Kobayashi Y,Miyake T,Uchino H,Ochi K

    更新日期:1984-08-15 00:00:00

  • Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: a Southwest Oncology Group Study.

    abstract::Between June 1977 and December 1978, occult testicular leukemia (OTL) was discovered at three years of continual complete remission (CCR) from the time of diagnosis of acute lymphoblastic leukemia (ALL) in 5 of 59 (8.5%) of males undergoing bilateral wedge testicular biopsy at 1 of 15 participating Southwest Oncology ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810201)47:3<470::aid-cncr28204

    authors: Askin FB,Land VJ,Sullivan MP,Ragab AH,Steuber CP,Dyment PG,Talbert J,Moore T

    更新日期:1981-02-01 00:00:00

  • A pathologic study of childhood lymphoma in Taiwan with special reference to peripheral T-cell lymphoma and the association with Epstein-Barr viral infection.

    abstract::The authors retrospectively reviewed the clinicopathologic and immunologic features of 65 consecutive cases of childhood lymphoma reported between 1980 and 1989. Southern blot hybridization was also performed in 23 cases to study their association with Epstein-Barr virus (EBV) and human T-cell leukemia virus type 1 (H...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911101)68:9<1954::aid-cncr2820

    authors: Lee SH,Su IJ,Chen RL,Lin KS,Lin DT,Chuu WM,Lin KS

    更新日期:1991-11-01 00:00:00

  • Elevation of serum levels of matrix metalloproteinase-2 and -3 as new predictors of recurrence in patients with urothelial carcinoma.

    abstract:BACKGROUND:The relationship between serum levels of matrix metalloproteinase-2 (MMP-2) and MMP-3 and recurrence in patients with urothelial carcinoma after complete resection was studied to determine whether the enzymes could be a new predictor of recurrence. METHODS:Serum levels of MMP-2 and MMP-3 in 146 healthy cont...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Gohji K,Fujimoto N,Komiyama T,Fujii A,Ohkawa J,Kamidono S,Nakajima M

    更新日期:1996-12-01 00:00:00

  • Thyroid-associated antigens in routinely embedded carcinomas. Possibilities and limitations studied in 116 cases.

    abstract::Routinely embedded tumors (116 cases) were screened immunohistochemically for the thyroid-associated antigens, thyroglobulin and calcitonin, and for carcinoembryonic antigen (CEA). Also the influence of different fixatives, decalcification, and embedding procedures were studied. All follicular and papillary carcinomas...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840715)54:2<274::aid-cncr28205

    authors: Logmans SC,Jöbsis AC

    更新日期:1984-07-15 00:00:00

  • Patient variables that predict atypical cytology by nipple duct lavage.

    abstract:BACKGROUND:Nipple duct lavage (NDL) may be useful for breast cancer risk stratification. Published guidelines recommend that women with a 5-year Gail risk >/=1.7% should consider undergoing lavage for any fluid-yielding ducts, but it is not known whether increased breast cancer risk or nipple fluid production predict l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22538

    authors: Bushnaq ZI,Ashfaq R,Leitch AM,Euhus D

    更新日期:2007-04-01 00:00:00

  • Combination hyperthermia and radiation therapy for malignant melanoma.

    abstract::Since 1975, clinical studies have been carried out to determine whether radiation when combined with localized hyperthermia evokes improved tumor control compared to that achieved with radiation alone. Local tumor hyperthermia was achieved using radiofrequency inductive heating at 27.12 MHz. In bulky lesions (greater ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820801)50:3<478::aid-cncr28205

    authors: Kim JH,Hahn EW,Ahmed SA

    更新日期:1982-08-01 00:00:00

  • Ferritin-bearing lymphocytes in the diagnosis of breast cancer.

    abstract::Four hundred forty-seven women attending a breast clinic because of either suspicious lesions, anxiety about breast cancer, follow-up after the removal of a benign breast lesion, or a family history of breast cancer had a routine test for percentage of ferritin-bearing lymphocytes ( FBL ) in their peripheral blood. Am...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840701)54:1<84::aid-cncr282054

    authors: Moroz C,Kan M,Chaimof C,Marcus H,Kupfer B,Cuckle HS

    更新日期:1984-07-01 00:00:00

  • Comparison of doubling times of serum carcinoembryonic antigen produced by various metastatic lesions in recurrent gastric and colorectal carcinomas.

    abstract::The authors measured the serial serum carcinoembryonic antigen (CEA) levels in patients with recurrent gastric or colorectal carcinoma. Among the 45 patients with recurrent gastric carcinomas, those with lung metastases showed the most prolonged CEA doubling time (CEA-DT), followed by those with liver and peritoneal m...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930615)71:12<4055::aid-cncr282

    authors: Umehara Y,Kimura T,Yoshida M,Oba N,Harada Y

    更新日期:1993-06-15 00:00:00

  • Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women.

    abstract:BACKGROUND:Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. METHODS:The authors evaluated common polymorphisms in the CYP1A1 gene in relation to breast carcinoma risk in a large population-based case-control study a...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.21056

    authors: Boyapati SM,Shu XO,Gao YT,Cai Q,Jin F,Zheng W

    更新日期:2005-06-01 00:00:00

  • Obesity, non-protein-bound estradiol levels, and distribution of estradiol in the sera of breast cancer patients.

    abstract::This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860201)57:3<558::aid-cncr28205

    authors: Ota DM,Jones LA,Jackson GL,Jackson PM,Kemp K,Bauman D

    更新日期:1986-02-01 00:00:00

  • Squamous cell carcinoma of the head and neck heterotransplanted to nude mice. Take rate in relation to patient survival.

    abstract::Biopsy specimens from 62 human single primary squamous cell carcinomas (SCC) of the head and neck were xenografted into nude mice. To evaluate the prognostic significance of successful heterotransplantation, the 62 cases were retrospectively examined for survival, adjusting for possible confounders by multivariate ana...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900701)66:1<145::aid-cncr28206

    authors: Zätterström UK,Wennerberg J,Attewell R,Ask A

    更新日期:1990-07-01 00:00:00

  • Disseminated coagulopathy in chronic myelomonocytic leukemia.

    abstract::The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197912)44:6<2249::aid-cncr282044

    authors: Gingrich RD,Burns CP

    更新日期:1979-12-01 00:00:00

  • Mixed germ cell-sex cord stroma tumor of the testis. A report with ultrastructural findings.

    abstract::The case of a 41-year-old man with testicular mixed germ cell-sex cord stroma tumor is reported. The patient noticed a gradual, painless, right-sided testicular enlargement 4 years before being treated by radical orchiectomy. The testis contained a centrally located tumor. There was no evidence of metastases. An histo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891115)64:10<2146::aid-cncr282

    authors: Matoŝka J,Talerman A

    更新日期:1989-11-15 00:00:00

  • Metastatic bronchogenic carcinoma to the bones of the hand.

    abstract::A case of bronchogenic carcinoma with polyostotic metastatasis to the phalanges is presented. The literature has also been extensively reviewed. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800215)45:4<824::aid-cncr28204

    authors: Nagendran T,Patel MN,Gaillard WE,Imm F,Walker M

    更新日期:1980-02-15 00:00:00

  • Reproductive history and prognosis in patients with operable breast cancer.

    abstract:BACKGROUND:Late menarche, early menopause, high parity, and early first birth decrease the risk of development of breast cancer. The influence of these factors on the survival of breast cancer patients has not been explained. METHODS:A group of 1885 patients with operable breast cancer was studied retrospectively. A u...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940901)74:5<1591::aid-cncr2820

    authors: Korzeniowski S,Dyba T

    更新日期:1994-09-01 00:00:00