Abstract:
:The individual medical histories in the files of the Oxford Record Linkage Study for the years 1963 to 1967 were analyzed to ascertain any previously unsuspected associations between cancers of the large bowel and other diseases in individuals, and to quantify the relative risks of disorders already known to be associated. In males significant associations were shown between cancers of the large bowel and cancer of the prostate. In females, cancer of the colon was associated with breast cancer, and cancer of the rectum with a mixed group of genital cancers. The relative risk of colorectal cancer associated with previous benign neoplasms of the large bowel was 20, and with ulcerative colitis, 25. There was no significant association with appendicitis or long-standing diverticular disease.
journal_name
Cancerjournal_title
Cancerauthors
Adelstein P,Baldwin JA,Fedrich Jdoi
10.1002/1097-0142(197906)43:6<2553::aid-cncr282043subject
Has Abstractpub_date
1979-06-01 00:00:00pages
2553-7issue
6eissn
0008-543Xissn
1097-0142journal_volume
43pub_type
杂志文章相关文献
CANCER文献大全abstract::Thirty-nine untreated patients with either lymphocytic or nodular mixed/nodular histiocytic non-Hodgkin's lymphoma, stage II--IV, were randomized to treatment with total body irradiation (TBI), 100 rads in 10 fractions over 12 days, plus combination chemotherapy with either cyclophosphamide, vincristine and prednisone...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197906)43:6<2227::aid-cncr282043
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:The role of prophylactic cranial irradiation (PCI) for patients with limited-stage small cell lung cancer (LSSCLC) remains a controversial issue. This study evaluated PCI in patients with LSSCLC who achieved a complete response to initial chemotherapy. METHODS:A retrospective case study of all nonprotocol p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950315)75:6<1302::aid-cncr2820
更新日期:1995-03-15 00:00:00
abstract:BACKGROUND:The treatment of advanced, inoperable, or recurrent parotid tumors represents a clinical challenge. The results obtained with conventional radiotherapy are disappointing. To improve the early response and local control of parotid tumors, local microwave hyperthermia was used in combination with ionizing radi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19950215)75:4<908::aid-cncr28207
更新日期:1995-02-15 00:00:00
abstract::A series of 273 unselected patients with bronchial carcinoma, comprising a total prospective 5-year study from a Swedish county with an observed 5-year survival of 7.0%, is presented. The autopsy rate in deceased patients was 94%. All diagnoses were histologically or cytologically verified. The 5-year survival rates f...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840515)53:10<2211::aid-cncr282
更新日期:1984-05-15 00:00:00
abstract::The experience of 260 patients with endometrial carcinoma was reviewed. The influence of factors such as age, stage of disease, grade and degree of myometrial penetration on the survival was presented, showing that survival decreases in elderly patients, in patients with advanced stage of disease, when the tumor is un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197702)39:2<675::aid-cncr2820390
更新日期:1977-02-01 00:00:00
abstract::One hundred thirty patients with histologically verified primary fibrosarcoma of bone, unassociated with any pre-existent benign bone condition, were treated at Memorial Sloan-Kettering Cancer Center between 1918 and 1973. This series of cases represents approximately 5% of primary malignant bone tumors treated in our...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3<837::aid-cncr2820350
更新日期:1975-03-01 00:00:00
abstract::The clinical presentation of the disease and the results of treatment in 42 patients with malignant peripheral neuroectodermal tumors (MPNT) entered into the Cooperative Ewing's, soft tissue, and neuroblastoma trials of the German Society of Pediatric Oncology were retrospectively analyzed. Within the Ewing's sarcoma ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880115)61:2<349::aid-cncr28206
更新日期:1988-01-15 00:00:00
abstract:BACKGROUND:Paclitaxel currently is administered by prolonged intravenous infusion because of the occurrence of severe hypersensitivity reactions in patients in early clinical trials. However, intensive premedication probably is more important in eliminating allergic reactions than is the length of infusion. The authors...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19940815)74:4<1377::aid-cncr2820
更新日期:1994-08-15 00:00:00
abstract:BACKGROUND:Commonly used chemotherapies can be toxic to the ovaries. To the authors' knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability. METHODS:A nationwide sample of US women d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32126
更新日期:2019-08-01 00:00:00
abstract::Fourteen new colorectal cancer cell lines were developed as part of a tumor acquisition, propagation, and preservation program for biotherapy. Fifty-six specimens were received. Nine cell lines were generated from biopsies; seven of these cell lines were from metastatic lesions. Five additional cell lines were develop...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891015)64:8<1600::aid-cncr2820
更新日期:1989-10-15 00:00:00
abstract::It is rare for small lymphocytic B-cell malignancies to be associated with osteolytic bone lesions and/or hypercalcemia. The authors present an unusual case of well-differentiated lymphocytic lymphoma (DWDL) in a 70-year-old man who had osteolytic bone lesions and subsequently developed severe refractory hypercalcemia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851115)56:10<2508::aid-cncr282
更新日期:1985-11-15 00:00:00
abstract::One hundred ninety patients who had advanced active Hodgkin's disease, lymphosarcoma, or reticulum cell sarcoma were treated with a combination of cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) given in a cyclical fashion every month. Complete remission was produced in 91 of 138 (66%) patients with...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197510)36:4<1241::aid-cncr282036
更新日期:1975-10-01 00:00:00
abstract::From 1975 until 1984 37 children with newly diagnosed Hodgkin's disease were treated with six mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) courses with or without involved field radiotherapy (25 Gy) independent of the stage of their disease. Patients with small lymph node tumors (less than 4 cm) r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870601)59:11<1870::aid-cncr282
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:The balance among cell proliferation, cell differentiation, and cell death determines the cell number in a population as well as the size or even the stage of a tumor. Thus, to improve our understanding of the pathogenesis of neoplasms, it is important to investigate the regulation of both cell proliferation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980615)82:12<2373::aid-c
更新日期:1998-06-15 00:00:00
abstract:BACKGROUND:Upfront autologous hematopoietic stem cell transplantation (AHCT) remains an important therapy in the management of patients with multiple myeloma (MM), a disease of older adults. METHODS:The authors investigated the outcomes of AHCT in patients with MM who were aged ≥70 years. The Center for International ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33171
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:To evaluate the pathologic characteristics of the primary tumor relative to local control, survival, and freedom from distant metastases, an analysis was performed of 172 patients with ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive breast ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/1097-0142(19930415)71:8<2532::aid-cncr2820
更新日期:1993-04-15 00:00:00
abstract:BACKGROUND:Although ascites cytology is important for therapeutic strategies, it is difficult to distinguish cancer infiltration from reactive mesothelial proliferation in some patients. In this study, the authors applied CDX2 immunocytochemistry to improve diagnostic accuracy. METHODS:The authors examined the distrib...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21840
更新日期:2006-04-25 00:00:00
abstract:BACKGROUND:Although several refinements have been reported for breast magnetic resonance imaging (MRI), there has been no uniform agreement by researchers on the optimal method. The authors report a simple and effective MRI method that incorporated the best qualities of other breast MRI methods yet eliminated the compl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010801)92:3<471::aid-cncr1345>
更新日期:2001-08-01 00:00:00
abstract::Retrospective immunocytochemical study of prolactin, growth hormone, ACTH, TSH and gonadotropins was performed on 150 pituitary adenomas from 142 patients and the results were correlated with clinical manifestations. There were 60 prolactin-positive tumors, 13 growth hormone-positive tumors, nine ACTH-positive tumors ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830815)52:4<648::aid-cncr28205
更新日期:1983-08-15 00:00:00
abstract:BACKGROUND:Carcinoid tumors are unusual and most reports are anecdotal or limited in number. A series of 2837 cases was published in 1975. No recent large series is available. METHODS:The authors evaluated 5468 cases identified by the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer In...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970215)79:4<813::aid-cnc
更新日期:1997-02-15 00:00:00
abstract:BACKGROUND:Current research is inconclusive regarding the relation between alcohol consumption and prostate cancer risk. In this study, the authors examined the associations of total alcohol, type of alcoholic beverage, and drinking pattern with the risk of total, low-grade, and high-grade prostate cancer. METHODS:Dat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24423
更新日期:2009-08-15 00:00:00
abstract::Sixty percent of all cancer occurs in persons aged > or =65 years. This article provides an overview of aspects of the burden of cancer in the elderly, highlighting certain demographic and epidemiologic data. It served as a frame of reference for participants in the Oncology Geriatric Education Retreat, San Juan, Puer...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197912)44:6<2249::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Small cell glioblastoma (GBM) is a variant with monomorphous, deceptively bland nuclei that often is misdiagnosed as anaplastic oligodendroglioma. METHODS:To elucidate its clinicopathologic and genetic features, the authors studied 71 adult patients (median age, 57 years), including 22 patients who were ide...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20625
更新日期:2004-11-15 00:00:00
abstract::The cell differentiation properties of two undifferentiated (embryonal) sarcomas of the liver (USL), one in a 9-year-old boy and one in a 23-year-old man, were studied by immunohistochemistry and electron microscopic examination. Both tumors showed a part pleomorphic pattern and a part myxoid spindle cell sarcomatous ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891115)64:10<2096::aid-cncr282
更新日期:1989-11-15 00:00:00
abstract:BACKGROUND:ThinPrep liquid-based cytology (TP) preparations are being used increasingly in nongynecologic specimens. To the authors' knowledge, few studies to date have evaluated TP cytology in the setting of small cell carcinoma of the lung (SCCL). Accurately differentiating SCCL from other lung tumors has important c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncy.20007
更新日期:2009-02-25 00:00:00
abstract:BACKGROUND:The current study analyzed the feasibility and outcome of stereotactic radiosurgery (SRS) for treatment of brain metastases from breast carcinoma. METHODS:During an 8-year period, 151 patients with a combined total of 620 brain metastases from breast carcinoma underwent 197 outpatient SRS procedures. Sixty-...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.20167
更新日期:2004-04-15 00:00:00
abstract::Between 1970 and 1989, 17 children with histologically malignant intracranial ependymomas received treatment at the University of Pennsylvania (Philadelphia, PA). Eleven were treated with prophylactic cranial or craniospinal irradiation plus a local boost (CS-XRT), five with local (L-XRT) irradiation only, and one was...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910601)67:11<2766::aid-cncr282
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:The objectives of this study were to evaluate survival among current smokers, former smokers, and never smokers who are diagnosed with non-small cell lung cancer (NSCLC). METHODS:The study included patients who participated in the National Comprehensive Cancer Network's NSCLC Database Project. Current, form...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27824
更新日期:2013-02-15 00:00:00
abstract:BACKGROUND:Preclinical and clinical data suggest that both leucovorin (LV) and interferon (IFN) can augment the cytotoxic effects of 5-fluorouracil (5-FU). Based on the rationale of biochemical double modulation, the current Phase II study was undertaken. METHODS:Thirty-two previously untreated patients with advanced ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19921001)70:7<1864::aid-cncr2820
更新日期:1992-10-01 00:00:00