Experience with vincristine, doxorubicin, and dexamethasone (VAD) chemotherapy in adults with refractory acute lymphocytic leukemia.

abstract：:Endodermal sinus tumor (EST) of the mediastinum is a rare germ-cell neoplasm affecting mainly young adult males. Ten patients with EST were treated with a multimodality approach that included surgery, chemotherapy, and radiotherapy. All patients had relapses after achieving a transient response except one who is still...

journal_title：Cancer

authors： Kuzur ME,Cobleigh MA,Greco FA,Einhorn LH,Oldham RK

更新日期：1982-08-15 00:00:00

abstract：:Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer-prone line (branches C and D) of the family, 20 of 21 members with cancer had one HL-A haplotype, HL-A2-HL-A12 (relativ...

journal_title：Cancer

authors： Lynch HT,Thomas RJ,Terasaki PI,Ting A,Guirgis HA,Kaplan AR,Magee H,Lynch J,Kraft C,Chaperon E

更新日期：1975-10-01 00:00:00

abstract：BACKGROUND:The head and neck region is one of the most common locations of rhabdomyosarcoma. Salivary gland involvement is usually secondary to advanced disease, and presentation as a primary salivary gland tumor is very rare. METHODS:Three cases of rhabdomyosarcoma presenting as parotid masses, in 2 boys (ages 3 and ...

journal_title：Cancer

authors： Salomão DR,Sigman JD,Greenebaum E,Cohen MB

更新日期：1998-08-25 00:00:00

abstract：:In certain experimental tumor models, tumor growth is less pronounced in immune deficient animals. Characteristically, tumors such as the murine B16 melanoma and Lewis lung carcinoma (3LL) are weakly antigenic. We proposed that with such tumors that are weakly antigenic, growth is enhanced by T-cell factors. Young mic...

journal_title：Cancer

authors： Ershler WB,Tuck D,Moore AL,Klopp RG,Kramer KE

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Coagulopathies often are associated with malignant tumors. The pathogenesis of these complications in cancer is not clear. Host inflammatory (monocyte/macrophage) cell-mediated triggering of clotting activation has been suggested. METHODS:The objective of this study was to evaluate the role of neutrophil-de...

journal_title：Cancer

authors： Gabazza E,Taguchi O,Yamakami T,Machishi M,Ibata H,Suzuki S

更新日期：1993-10-01 00:00:00

abstract：:Canada is a westernized, market-economy nation with a publicly funded health care and cancer control system and has health indices reflective of a high-resource economy. Provision of health services is in accord with the Canada Health Act and is implemented through federal, provincial, and territorial relations wherei...

journal_title：Cancer

authors： Sutcliffe SB

更新日期：2011-05-15 00:00:00

abstract：:Oxygen remains one of the most potent sensitizers of mammalian cells yet studied and, most important, it is maximumly sensitizing at physiologic concentrations. There is very good evidence that solid tumors of both experimental animals and man contain hypoxic and viable cells. In experimental animals hyperbaric oxygen...

journal_title：Cancer

authors： Suit HD

更新日期：1968-10-01 00:00:00

abstract：:In 1988, Californians passed Proposition 99, which raised the tobacco tax from 10 cents to 35 cents and allocated 20% of the resulting revenues, approximately $100 million, for tobacco education and 5% for tobacco-related research. Seventy percent was allocated for health care costs and 5% for the environment. In this...

journal_title：Cancer

authors： Martin CB,Beerline D,Breslow L

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Attrition is common among supportive care/palliative oncology clinical trials. However, to the authors' knowledge, few studies to date have documented the reasons and predictors for dropout. In the current study, the authors' objective was to determine the rate, reasons, and factors associated with attrition...

journal_title：Cancer

authors： Hui D,Glitza I,Chisholm G,Yennu S,Bruera E

更新日期：2013-03-01 00:00:00

abstract：:Data on patients with gallbladder cancer listed in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed. Between 1977 and 1986, 3038 patients were recorded in the Program. Histologic grade, histologic type, stage of disease, and vascular invasion were correlated...

journal_title：Cancer

authors： Henson DE,Albores-Saavedra J,Corle D

更新日期：1992-09-15 00:00:00

abstract：BACKGROUND:In preclinical Ewing sarcoma (ES) models, poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors were identified as a potential therapeutic strategy with synergy in combination with cytotoxic agents. This study evaluated the safety and dosing of the PARP1/2 inhibitor niraparib (NIR) with temozolomid...

journal_title：Cancer

authors： Chugh R,Ballman KV,Helman LJ,Patel S,Whelan JS,Widemann B,Lu Y,Hawkins DS,Mascarenhas L,Glod JW,Ji J,Zhang Y,Reinke D,Strauss SJ

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:To the authors' knowledge, outcomes and prognostic tools have yet to be clearly defined in patients with metastatic renal cell carcinoma (mRCC) who are treated with immuno-oncology (IO) checkpoint inhibitors (programmed death-ligand 1 [PD-L1] inhibitors). In the current study, the authors aimed to establish ...

journal_title：Cancer

authors： Yip SM,Wells C,Moreira R,Wong A,Srinivas S,Beuselinck B,Porta C,Sim HW,Ernst DS,Rini BI,Yuasa T,Basappa NS,Kanesvaran R,Wood LA,Canil C,Kapoor A,Fu SYF,Choueiri TK,Heng DYC

更新日期：2018-09-15 00:00:00

abstract：:Twenty-four children aged 3 months to 18 years (median, 12 years) were treated for neurogenic sarcoma at the Children's Hospital of Philadelphia Cancer Research Center from 1958 through 1984. Sixteen patients had neurofibromatosis (NF). The tumors arose in an extremity or in the trunk (15 patients), the retroperitoneu...

journal_title：Cancer

authors： Raney B,Schnaufer L,Ziegler M,Chatten J,Littman P,Jarrett P

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Male breast cancer (MBC) is considered an androgen-dependent tumor, and as in prostatic cancer, responses have been reported with use of antiandrogens or gonadotropin-releasing hormone analogs. Thus, it is reasonable to postulate that better results could be achieved by combining these two agents. METHODS:E...

journal_title：Cancer

authors： Lopez M,Natali M,Di Lauro L,Vici P,Pignatti F,Carpano S

更新日期：1993-07-15 00:00:00

abstract：:Treatment with BCG (Bacillus Calmette-Guérin) followed by irradiation was attempted to improve response to therapy by cutaneous metastases from malignant skin melanomas. Both agents were applied in low doses, known to cause minimal side effects. Nineteen patients, divided into three groups, entered the clinical trial....

journal_title：Cancer

authors： Plesnicar S,Rudolf Z

更新日期：1982-09-15 00:00:00

abstract：:Leukemic cells from 13 patients with therapy-related acute nonlymphocytic leukemia (ANLL) were studied by electron microscopy. All of the patients had radiotherapy, and/or alkylating agent chemotherapy for other neoplastic disease 25 to 182 months prior to the diagnosis of ANLL. All cases manifested ultrastructural ev...

journal_title：Cancer

authors： McKenna RW,Parkin JL,Foucar K,Brunning RD

更新日期：1981-08-01 00:00:00

abstract：:Based on the independent activity of cisplatin, vinblastine, and dimethyl-triazeno-imidazole-carboxamide (DTIC) (CVD), a combination of these agents was used in the treatment of patients with advanced melanoma. Vinblastine was used in a dose of 1.6 mg/m2/d for 5 days, DTIC was used in a dose of 800 mg/m2 intravenously...

journal_title：Cancer

authors： Legha SS,Ring S,Papadopoulos N,Plager C,Chawla S,Benjamin R

更新日期：1989-11-15 00:00:00

abstract：BACKGROUND:The incidence of hepatocellular carcinoma (HCC) has been rising rapidly in the United States. California is an ethnically diverse state with the largest number of incident HCC cases in the country. Characterizing HCC disparities in California may inform priorities for HCC prevention. METHODS:By using data f...

journal_title：Cancer

authors： Yang B,Liu JB,So SK,Han SS,Wang SS,Hertz A,Shariff-Marco S,Lin Gomez S,Rosenberg PS,Nguyen MH,Hsing AW

更新日期：2018-09-01 00:00:00

abstract：:Fifty-three patients with advanced lymphocytic lymphoma were randomly assigned to treatment with the combination cyclophosphamide, vincristine, and prednisone (CVP) or the same agents used successively in maximal doses (C-V-P). Complete remissions occurred in 68% with CVP and 48% with C-V-P. For patients with nodular ...

journal_title：Cancer

authors： Kennedy BJ,Bloomfield CD,Kiang DT,Vosika G,Peterson BA,Theologides A

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Preclinical and clinical data suggest that both leucovorin (LV) and interferon (IFN) can augment the cytotoxic effects of 5-fluorouracil (5-FU). Based on the rationale of biochemical double modulation, the current Phase II study was undertaken. METHODS:Thirty-two previously untreated patients with advanced ...

journal_title：Cancer

authors： Scheithauer W,Pfeffel F,Kornek G,Marczell A,Wiltschke C,Funovics J

更新日期：1992-10-01 00:00:00

abstract：:During the past 30 years, changes in the treatment of children and adolescents with cancer have led to substantial improvements in survival. Although treatment-related factors have been shown to impact subsequent health status and quality of life, there is limited information on survivors who are now two or more decad...

journal_title：Cancer

authors： Robison LL,Green DM,Hudson M,Meadows AT,Mertens AC,Packer RJ,Sklar CA,Strong LC,Yasui Y,Zeltzer LK

更新日期：2005-12-01 00:00:00

abstract：:The body composition of 23 patients with cachexia resulting from malignant or benign inflammatory disease was studied. Skinfold thickness and radioisotope tracer measurements enabled us to estimate total body fat, lean body mass, the ratio of fat loss to lean body loss, erythrocyte and plasma volumes, total body water...

journal_title：Cancer

authors： Watson WS,Sammon AM

更新日期：1980-11-01 00:00:00

abstract：:Fifteen cases of pure supradiapragmatic lymphoma with initial prominent antero-superior mediastinal involvement displaying a B-cell pattern of reactivity were studied. These cases occurred in six men and nine women with a median age of 33 years at diagnosis (range, 23 to 75 years). Supradiapragmatic peripheral lymphad...

journal_title：Cancer

authors： Lavabre-Bertrand T,Donadio D,Fegueux N,Jessueld D,Taib J,Charlier D,Rousset T,Emberger JM,Baldet P,Navarro M

更新日期：1992-05-15 00:00:00

abstract：BACKGROUND:Oral tongue cancer incidence has increased among whites in the United States; however, the cause remains unknown. If an infectious agent is implicated, then elevated risk would be expected among immunosuppressed individuals. METHODS:By using population-based registry linkage information from the US Transpla...

journal_title：Cancer

authors： Tota JE,Engels EA,Madeleine MM,Clarke CA,Lynch CF,Ortiz AP,Hernandez BY,Chaturvedi AK

更新日期：2018-06-15 00:00:00

abstract：:Two patients fulfilled the clinical and hematologic criteria for B-cell acute lymphoblastic leukemia: the malignant cells had L3 morphology, bore B-cell markers, and carried the specific t(8;14) translocation. The leukemic cells of one patient were tetrasomic for 1q, and those of the other patient showed several separ...

journal_title：Cancer

authors： Morris CM,Fitzgerald PH,Neville MA,Wyld PJ,Beard ME

更新日期：1984-07-01 00:00:00

abstract：:A retrospective analysis of a series of 162 patients treated for isolated chest wall recurrence of breast cancer after mastectomy was undertaken. Cumulative survival, distant relapse-free survival, and freedom from local progression after 5 years from the diagnosis of recurrence were 34%, 28%, and 45% respectively. Fi...

journal_title：Cancer

authors： Magno L,Bignardi M,Micheletti E,Bardelli D,Plebani F

更新日期：1987-07-15 00:00:00

abstract：:Progress in the treatment of pancreatic cancer in the past several decades has been very modest. Several new agents with activity against this disease have been identified. Of these, gemcitabine appears to be the most promising when used in combination with other drugs. Gemcitabine and cisplatin combinations have been...

journal_title：Cancer

authors： Philip PA

更新日期：2002-08-15 00:00:00

abstract：:Urinary polyamine concentrations in 91 samples were assayed in 79 patients with malignant melanoma who were classified as to clinical stage, as well as to activity of disease. Patients with active disease had higher mean polyamine values, increased frequency of polyamine elevations, and increased frequency of two or m...

journal_title：Cancer

authors： Townsend RM,Banda PW,Marton LJ

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:The authors investigated the putative surrogate endpoints of best response, complete response (CR), confirmed response, and progression-free survival (PFS) for associations with overall survival (OS), and as possible surrogate endpoints for OS. METHODS:Individual patient data from 870 untreated extensive st...

journal_title：Cancer

authors： Foster NR,Qi Y,Shi Q,Krook JE,Kugler JW,Jett JR,Molina JR,Schild SE,Adjei AA,Mandrekar SJ

更新日期：2011-03-15 00:00:00

abstract：:This article describes two patients with hepatic metastases from colorectal cancer in whom a reversible enteropathy developed during the administration of hepatic artery infusion chemotherapy with 5-fluoro-2-deoxyuridine (5-FUdR) via an Infusaid Series 400 pump (Infusaid Corp., Sharon, MA). Both patients had severe di...

journal_title：Cancer

authors： Gluck WL,Akwari OE,Kelvin FM,Goodwin BJ

更新日期：1985-11-15 00:00:00