Abstract:
BACKGROUND:The uptake of thallium-201 (T1-201) in malignant tumors is associated with malignant potential (metastatic potential and proliferative activity). The grade of accumulation of T1-201 in malignant tumors may provide information regarding prognosis. METHODS:A T1-201 single photon emission computed tomography was conducted 120 minutes after intravenous injection of 111 megabecquerel of T1-201 chloride. The authors calculated the uptake ratio to evaluate the degree of T1-201 uptake in the primary tumor. This ratio was compared with survival time and other prognostic factors. RESULTS:The authors studied 152 patients (125 men and 27 women). The group of patients with the low T1-201 uptake ratio survived longer than the group of patients with the high T1-201 uptake ratio (median survival, 58 weeks vs. 33 weeks; P = 0.0138 by the log rank test). The multivariate analysis confirmed that the T1-201 uptake ratio was an independent prognostic factor for survival. CONCLUSIONS:These results suggest that the T1-201 uptake ratio provides independent and objective prognostic information for patients with lung carcinoma.
journal_name
Cancerjournal_title
Cancerauthors
Takekawa H,Takaoka K,Tsukamoto E,Kanegae K,Miller F,Kawakami Ydoi
10.1002/(sici)1097-0142(19970715)80:2<198::aid-cncsubject
Has Abstractpub_date
1997-07-15 00:00:00pages
198-203issue
2eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19970715)80:2<198::AID-CNCjournal_volume
80pub_type
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