Utilization and expense of adjuvant cancer therapies following radical prostatectomy.


BACKGROUND:We sought to identify the costs of adjuvant therapies following radical prostatectomy (RP) and factors associated with their receipt. METHODS:We used SEER-Medicare data from 2004-2006 to identify 4247 men who underwent RP, of whom 600 subsequently received adjuvant therapies. We used Cox regression to identify factors associated with receipt of adjuvant therapies. Health care expenditures within 12 months of diagnosis were compared for RP alone versus RP with adjuvant therapies. RESULTS:Biopsy Gleason score, prostate-specific antigen, risk group, and SEER region were significantly associated with receipt of adjuvant treatments (all P<.001). Higher surgeon volume was associated with lower odds of receiving adjuvant therapies (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.46-0.78 [P<.001]). Factors associated with increased receipt of adjuvant therapies were positive surgical margins (HR, 3.02; 95% CI, 2.55-3.57 [P<.001]), high-risk group versus low-risk group (HR, 7.65; 95% CI, 5.64-10.37 [P<.001]), lymph node-positive disease (HR, 5.36; 95% CI, 3.71-7.75 [P<.001]), and treatment in Iowa (HR, 1.93; 95% CI, 1.12-3.32 [P = .019]) and New Mexico/Georgia/Hawaii (HR, 1.92; 95% CI, 1.09-3.39 [P = .025]) versus San Francisco SEER regions (baseline). Age, race, comorbidities, and surgical approach were not associated with use of adjuvant therapies. The median expenditures attributable to postprostatectomy hormonal therapy, radiation therapy, and radiation with hormonal therapy versus were $1361, $12,040, and $23,487. CONCLUSIONS:Men treated by high-volume surgeons were less likely to receive adjuvant therapies. Regional variation and high-risk disease characteristics were associated with increased receipt of adjuvant therapies, which increased health care expenditures by 2- to 3-fold when radiotherapy was administered.






Williams SB,Gu X,Lipsitz SR,Nguyen PL,Choueiri TK,Hu JC




Has Abstract


2011-11-01 00:00:00














  • Systemic giant-cell histiocytosis: report of a case and a review of the adult form of Letterer-Siwe disease.

    abstract::The multiple classifications of histiocytic disorders, and the lack of specificity in their application, have degraded the utility of such diagnostic terms as "Letterer-Siwe Disease" and "Malignant Histiocytosis". A case is presented of a systemic histiocytic proliferation with erythrophagocytosis and giant-cell forma...


    pub_type: 杂志文章,评审


    authors: Wolfson WL,Gossett T,Pagani J

    更新日期:1976-12-01 00:00:00

  • A compound follicular-parafollicular cell carcinoma of the thyroid: a new tumor entity?

    abstract::An unusual thyroid carcinoma is described, showing structural, histochemical and radioimmunologic features of both a follicular and a parafollicular cell carcinoma. Radioimmunoassay revealed high levels of thyroglobulin in the patient's serum and in extracts from metastatic tumor tissue. Immunoreactive thyroglobulin w...


    pub_type: 杂志文章


    authors: Ljungberg O,Ericsson UB,Bondeson L,Thorell J

    更新日期:1983-09-15 00:00:00

  • Virilizing adrenocortical tumors in adult women. Report of 10 patients, 2 of whom each had a tumor secreting only testosterone.

    abstract:BACKGROUND:Virilizing adrenocortical tumors are uncommon in adult women. These lesions generally secrete dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), but not testosterone, which usually is produced by ovarian tumors. Exceptionally, adrenal growths may give off testosterone and no other asse...


    pub_type: 杂志文章


    authors: Del Gaudio AD,Del Gaudio GA

    更新日期:1993-09-15 00:00:00

  • Significance and possible causes of false-negative results of reflex human Papillomavirus infection testing.

    abstract:BACKGROUND:The objective of this study was to assess the rate and possible reasons for false-negative (FN) reflex human papillomavirus (HPV)-DNA tests. METHODS:The authors reviewed all ThinPrep cervical specimens that were submitted for reflex HPV-DNA testing using the Digene Hybrid Capture II (HC2) method from Januar...


    pub_type: 杂志文章


    authors: Eltoum IA,Chhieng DC,Crowe DR,Roberson J,Jin G,Broker TR

    更新日期:2007-06-25 00:00:00

  • The effects of pain severity on health-related quality of life: a study of Chinese cancer patients.

    abstract:BACKGROUND:The health-related functioning of patients with cancer is compromised by several factors, including the disease process, treatment, and the various symptoms that are produced by both disease and treatment. This study was designed to specify the relationship between patients' pain severity and their self-repo...


    pub_type: 杂志文章


    authors: Wang XS,Cleeland CS,Mendoza TR,Engstrom MC,Liu S,Xu G,Hao X,Wang Y,Ren XS

    更新日期:1999-11-01 00:00:00

  • HBAg-positive chronic liver disease associated with cirrhosis and hepatocellular carcinoma in the Senoi.

    abstract::Necropsy and clinical data show that primary hepatocellular carcinoma (PHC) is the commonest cancer among the Senoi (a Malaysian aboringine group). The other aboringine tribes do not appear to have this high predilection for liver cancer. In the necropsy series, PHS was present in 10 out of 22 Senoi patients with cirr...


    pub_type: 杂志文章


    authors: Sumithran E,Prathap K

    更新日期:1977-10-01 00:00:00

  • Small bore catheter drainage and sclerotherapy for malignant pleural effusions.

    abstract::The accumulation of large amounts of fluid in the pleural space is a common sequela of disseminated carcinomatosis. Traditional management has included therapeutic thoracentesis or the placement of a large bore chest tube for drainage with the subsequent installation of a sclerosing agent in an attempt to achieve pleu...


    pub_type: 杂志文章


    authors: Parker LA,Charnock GC,Delany DJ

    更新日期:1989-09-15 00:00:00

  • Combination therapy with interferon-dexamethasone for newly diagnosed patients with multiple myeloma.

    abstract:BACKGROUND:Alpha-interferon and dexamethasone are each effective in patients with multiple myeloma and have a combined inhibitory effect on the in vitro growth of myeloma colonies. The effect of combined therapy in newly diagnosed patients is unknown. METHODS:Fifty-one consecutive patients with previously untreated mu...


    pub_type: 杂志文章


    authors: Dimopoulos MA,Weber D,Delasalle KB,Alexanian R

    更新日期:1993-11-01 00:00:00

  • Enzyme pattern and marker antigens in nodular "regenerative" hyperplasia of the liver.

    abstract::Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was dem...


    pub_type: 杂志文章


    authors: Thung SN,Gerber MA

    更新日期:1981-04-01 00:00:00

  • Long-term follow-up of patients with newly diagnosed acute myeloid leukemia treated at the University of Texas M.D. Anderson Cancer Center.

    abstract:BACKGROUND:Chemotherapy is known to cure a small minority of patients with acute myeloid leukemia (AML). Less is known about the risk of such patients developing subsequent cancers or about their ability to return to work. METHODS:The authors analyzed outcomes among 1892 patients who received treatment for newly diagn...


    pub_type: 杂志文章


    authors: Estey E,deLima M,Strom S,Pierce S,Freireich EJ,Keating MJ

    更新日期:1997-12-01 00:00:00

  • Chemotherapy for advanced or recurrent gynecologic cancer.

    abstract::Studies of chemotherapy in advanced or recurrent gynecologic cancer have focussed on ovarian, cervical, and endometrial carcinoma. For celomic epithelial carcinomas of the ovary, a large number of cytotoxic agents have been shown to be active. Dramatic improvement in frequency of response with lesser improvement in su...


    pub_type: 杂志文章,评审


    authors: Thigpen T,Vance R,Lambuth B,Balducci L,Khansur T,Blessing J,McGehee R

    更新日期:1987-10-15 00:00:00

  • Systematic pelvic and aortic lymphadenectomy in elderly gynecologic oncologic patients.

    abstract:BACKGROUND:Retroperitoneal lymph node dissection is a fundamental step in the surgical management of patients with pelvic gynecologic malignancies, but its applicability to geriatric patients is controversial. The objective of this study was to evaluate whether pelvic and aortic lymphadenectomy in elderly patients with...


    pub_type: 杂志文章


    authors: Giannice R,Susini T,Ferrandina G,Poerio A,Margariti PA,Carminati R,Marana E,Mancuso S,Scambia G

    更新日期:2001-11-15 00:00:00

  • Patterns of Care Study quantitative evaluation of the quality of radiotherapy in Japan.

    abstract:BACKGROUND:Quality assurance (QA) of clinical practice is important for any medical specialty. Programs based on the Patterns of Care Study (PCS) have been developed to compare the quality of radiotherapeutic care at individual institutions, with the national average representing the process and outcome of radiotherapy...


    pub_type: 杂志文章


    authors: Tanisada K,Teshima T,Ohno Y,Inoue T,Abe M,Ikeda H,Owen JB,Hanks GE,Masuda K,Honke Y

    更新日期:2002-07-01 00:00:00

  • Head and neck aspergillosis in patients undergoing bone marrow transplantation. Report of four cases and review of the literature.

    abstract::Aspergillus infection can be a major cause of morbidity in immunocompromised patients, especially when there is pulmonary involvement. Diagnosis of aspergillosis is often complicated by the varied clinical presentation and compromised medical status of such patients. Four cases of head and neck Aspergillus infections ...


    pub_type: 杂志文章


    authors: Schubert MM,Peterson DE,Meyers JD,Hackman R,Thomas ED

    更新日期:1986-03-15 00:00:00

  • Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.

    abstract:BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...


    pub_type: 杂志文章


    authors: Seidinger AL,Mastellaro MJ,Paschoal Fortes F,Godoy Assumpção J,Aparecida Cardinalli I,Aparecida Ganazza M,Correa Ribeiro R,Brandalise SR,Dos Santos Aguiar S,Yunes JA

    更新日期:2011-05-15 00:00:00

  • Pretreatment and routine echocardiogram monitoring during chemotherapy for anthracycline-induced cardiotoxicity rarely identifies significant cardiac dysfunction or alters treatment decisions: a 5-year review at a single pediatric oncology center.

    abstract:BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...


    pub_type: 杂志文章


    authors: Watts RG,George M,Johnson WH Jr

    更新日期:2012-04-01 00:00:00

  • The molecular basis of ovarian cancer.

    abstract:BACKGROUND:Molecular genetic studies of ovarian cancer have been limited by the inaccessible location of the ovary, the advanced stage of tumors available for analysis, and the lack of a well-defined precursor lesion. However, genetic alterations important in ovarian tumorigenesis have been identified recently. METHOD...


    pub_type: 杂志文章,评审


    authors: Gallion HH,Pieretti M,DePriest PD,van Nagell JR Jr

    更新日期:1995-11-15 00:00:00

  • Restoring platinum sensitivity in recurrent ovarian cancer by extending the platinum-free interval: Myth or reality?

    abstract::The platinum-free interval is the most important predictive factor of a response to subsequent lines of chemotherapy and the most important prognostic factor for progression-free and overall survival in patients with recurrent epithelial ovarian cancer. A nonplatinum regimen is generally considered the most appropriat...


    pub_type: 杂志文章,评审


    authors: Tomao F,D'Incalci M,Biagioli E,Peccatori FA,Colombo N

    更新日期:2017-09-15 00:00:00

  • Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors.

    abstract:BACKGROUND:In late reproductive-aged breast cancer survivors, there is a need for real-time biomarkers of postchemotherapy ovarian function. The objective was to determine whether antimullerian hormone (AMH) and inhibin B are such biomarkers. The authors tested whether AMH and inhibin B were impacted by breast cancer t...


    pub_type: 杂志文章


    authors: Su HI,Sammel MD,Green J,Velders L,Stankiewicz C,Matro J,Freeman EW,Gracia CR,DeMichele A

    更新日期:2010-02-01 00:00:00

  • Second solid cancers after allogeneic hematopoietic stem cell transplantation.

    abstract:BACKGROUND:The objective of this study was to establish the incidence and risk factors for the development of second solid cancers after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:The authors reviewed the case files of 926 consecutive patients who underwent allo-HSCT at their institution b...


    pub_type: 杂志文章


    authors: Gallagher G,Forrest DL

    更新日期:2007-01-01 00:00:00

  • Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticals.

    abstract::Pain management often is difficult in patients with bone metastases. Metastatic disease represents >40% of oncologic practice, and >70% of patients with metastatic disease have uncontrolled cancer-related pain. Significant morbidity caused by pathologic fracture and spinal cord compression can result from untreated bo...


    pub_type: 杂志文章,评审


    authors: Janjan NA

    更新日期:1997-10-15 00:00:00

  • Prediction of outcome in metastatic breast cancer treated with adriamycin combination chemotherapy.

    abstract::Univariate and multivariate regression methods were used to analyze 17 potential clinical prognostic factors among 138 patients with advanced breast cancer who received Adriamycin-cyclophosphamide combination chemotherapy between 1973 and 1977 at the University of Arizona. Follow-up of patients was through September 1...


    pub_type: 杂志文章


    authors: Nash CH 3rd,Jones SE,Moon TE,Davis SL,Salmon SE

    更新日期:1980-12-01 00:00:00

  • Indomethacin sensitive suppressor-cell activity in head and neck cancer patients. The role of the adherent mononuclear cell.

    abstract::Head and neck cancer (H&N CA) patients have known depression of cell-mediated immunity. There is suggestive evidence that prostaglandin (PGE2)-secreting cells may be a major factor. The authors have sought to determine the role of PGE2-releasing monocytes-macrophages in this immune depression by determining the effect...


    pub_type: 杂志文章


    authors: Wanebo HJ,Riley T,Katz D,Pace RC,Johns ME,Cantrell RW

    更新日期:1988-02-01 00:00:00

  • Combination therapy of hormone and cytotoxic agents in advanced breast cancer.

    abstract::The effectiveness of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES + CTx + FU) was compared with DES alone or CTx + FU in 87 postmenopausal women with advanced breast cancer. Therapy was randomized according to the tumor estrogen-receptor (ER) status. In 30 patients with ER-ric...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kiang DT,Frenning DH,Gay J,Goldman AI,Kennedy BJ

    更新日期:1981-02-01 00:00:00

  • Urinary pepsinogen I as a tumor marker of stomach cancer after total gastrectomy.

    abstract::The possibility that urinary pepsinogen I is a tumor marker of stomach cancer after total gastrectomy was examined. To decide the cutoff level of urinary pepsinogen I after total gastrectomy, urine samples from 15 patients who had undergone total gastrectomy for stomach cancer in the early or advanced stages and had b...


    pub_type: 杂志文章


    authors: Yamaguchi T,Takahashi T,Yokota T,Kitamura K,Noguchi A,Kamiguchi M,Doi M,Ahn T,Sawai K,Yamane T

    更新日期:1991-08-15 00:00:00

  • Breast conservation therapy as a treatment option for the elderly. The M. D. Anderson experience.

    abstract:BACKGROUND:Although almost half of all incidents of breast carcinoma occur in women age > or = 65 years, not enough is known about appropriate care for patients in this age group. The objective of the current study was to evaluate the role of breast conservation therapy in the management of breast carcinoma in women ag...


    pub_type: 杂志文章


    authors: Vlastos G,Mirza NQ,Meric F,Hunt KK,Kuerer HM,Ames FC,Ross MI,Buchholz TA,Hortobagyi GN,Singletary SE

    更新日期:2001-09-01 00:00:00

  • Identification of circulating micromegakaryocytes in a case of erythroleukemia.

    abstract::A 26-year-old man with erythroleukemia was found to have circulating micromegakaryocytes . Megakaryocytic features were defined by morphologic and cytochemical studies using light and electron microscopy with platelet-megakaryocyte peroxidase staining. This appears to be the first reported instance of erythroleukemia ...


    pub_type: 杂志文章


    authors: Yamauchi K,Miyauchi J,Nagao T

    更新日期:1984-06-15 00:00:00

  • Prognosis in adult acute myelogenous leukemia related to performance status and other factors.

    abstract::Pretreatment factors of prognostic value were sought in 54 consecutively treated cases of adult acute myelogenous leukemia. Twenty of 37 patients with a good (greater than 50%) pretreatment Karnofsky performance status (P.S.) achieved complete remission (C.R.), while only 1/17 with a poor P.S. achieved C.R. This diffe...


    pub_type: 杂志文章


    authors: Kansal V,Omura GA,Soong SJ

    更新日期:1976-07-01 00:00:00

  • Religion, spirituality, and health outcomes in cancer: A case for a meta-analytic investigation.

    abstract::A growing body of research shows that a majority of patients with cancer report having religious and spiritual (R/S) beliefs, engaging in R/S behaviors, or deriving comfort from R/S experiences. These studies have been reviewed but not subjected to rigorous critical analysis. A meta-analytic approach is needed to prov...


    pub_type: 杂志文章,meta分析


    authors: Salsman JM,Fitchett G,Merluzzi TV,Sherman AC,Park CL

    更新日期:2015-11-01 00:00:00

  • Ocular toxicity and cancer chemotherapy. A review.

    abstract:BACKGROUND:Systemic anticancer therapies can produce acute and chronic organ damage, but the eye is usually considered a protected site. Nonetheless, the oculo-visual system has a potentially high degree of sensitivity to toxic substances. Ocular toxicity induced by cancer chemotherapy includes a broad spectrum of diso...


    pub_type: 杂志文章,评审


    authors: al-Tweigeri T,Nabholtz JM,Mackey JR

    更新日期:1996-10-01 00:00:00