Utilization and expense of adjuvant cancer therapies following radical prostatectomy.


BACKGROUND:We sought to identify the costs of adjuvant therapies following radical prostatectomy (RP) and factors associated with their receipt. METHODS:We used SEER-Medicare data from 2004-2006 to identify 4247 men who underwent RP, of whom 600 subsequently received adjuvant therapies. We used Cox regression to identify factors associated with receipt of adjuvant therapies. Health care expenditures within 12 months of diagnosis were compared for RP alone versus RP with adjuvant therapies. RESULTS:Biopsy Gleason score, prostate-specific antigen, risk group, and SEER region were significantly associated with receipt of adjuvant treatments (all P<.001). Higher surgeon volume was associated with lower odds of receiving adjuvant therapies (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.46-0.78 [P<.001]). Factors associated with increased receipt of adjuvant therapies were positive surgical margins (HR, 3.02; 95% CI, 2.55-3.57 [P<.001]), high-risk group versus low-risk group (HR, 7.65; 95% CI, 5.64-10.37 [P<.001]), lymph node-positive disease (HR, 5.36; 95% CI, 3.71-7.75 [P<.001]), and treatment in Iowa (HR, 1.93; 95% CI, 1.12-3.32 [P = .019]) and New Mexico/Georgia/Hawaii (HR, 1.92; 95% CI, 1.09-3.39 [P = .025]) versus San Francisco SEER regions (baseline). Age, race, comorbidities, and surgical approach were not associated with use of adjuvant therapies. The median expenditures attributable to postprostatectomy hormonal therapy, radiation therapy, and radiation with hormonal therapy versus were $1361, $12,040, and $23,487. CONCLUSIONS:Men treated by high-volume surgeons were less likely to receive adjuvant therapies. Regional variation and high-risk disease characteristics were associated with increased receipt of adjuvant therapies, which increased health care expenditures by 2- to 3-fold when radiotherapy was administered.






Williams SB,Gu X,Lipsitz SR,Nguyen PL,Choueiri TK,Hu JC




Has Abstract


2011-11-01 00:00:00














  • Functional outcome of pathologic fracture secondary to malignant disease in a rehabilitation hospital.

    abstract::Fifty-eight patients with 62 pathologic fractures secondary to metastatic disease were admitted to a rehabilitation hospital during a 5-year period. Thirty-four patients were discharged home, 7 were transferred to other facilities, and 17 died. The average hospital stay for the patients who went home (37 days) was onl...


    pub_type: 杂志文章


    authors: Bunting RW,Boublik M,Blevins FT,Dame CC,Ford LA,Lavine LS

    更新日期:1992-01-01 00:00:00

  • Non-Hodgkin's lymphoma in children: an analysis of 122 cases from Argentina.

    abstract::One hundred twenty two children with non-Hodgkin's lymphoma were studied from January 1966 to December 1975. The first group (1966-1972) did not receive an uniform treatment. The second group (1973-1975) entered in a G.A.T.L.A. protocol consisting of: vincristine-prednisone plus surgery and/or radiotherapy as inductio...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cebrian-Bonesana A,Schvartzman E,Roca-Garcia C,Pependieck C,Sackmann-Muriel S,Ojeda FG,Kvicala R,Pavlovsky S,Lein JM,Penchansky L

    更新日期:1978-06-01 00:00:00

  • The prognosis of patients with stage III melanoma. Prospective long-term study of 286 patients of the Fachklinik Hornheide.

    abstract:BACKGROUND:Prognostic factors for patients with stage III melanoma are still controversial. METHODS:Two hundred eighty-six patients with solitary cutaneous malignant melanoma of the skin in Stage III (International Union Against Cancer [UICC]) were followed up for as long as 11 years. RESULTS:Patients in risk group p...


    pub_type: 杂志文章


    authors: Drepper H,Biess B,Hofherr B,Hundeiker M,Lippold A,Otto F,Padberg G,Peters A,Wiebelt H

    更新日期:1993-02-15 00:00:00

  • K-ras activation in colorectal tumors from patients with familial polyposis coli.

    abstract::K-ras gene mutation in colorectal tumors from patients with familial polyposis coli were investigated using oligonucleotide probes specific for a mutation at codon 12, 13, or 61 of the K-ras gene. The authors examined 22 colorectal carcinomas and 51 colorectal adenomas from 41 familial polyposis coli patients and obse...


    pub_type: 杂志文章


    authors: Sasaki M,Sugio K,Sasazuki T

    更新日期:1990-06-01 00:00:00

  • The long-term postsurgical prognosis of patients with pineoblastoma.

    abstract:BACKGROUND:For this report, the authors comprehensively summarized the existing literature on patients with pineoblastoma and identified the variables and treatments that had an impact patient on outcomes. METHODS:A comprehensive search identified 109 studies that collectively described the outcomes of patients with p...


    pub_type: 杂志文章,评审


    authors: Tate M,Sughrue ME,Rutkowski MJ,Kane AJ,Aranda D,McClinton L,McClinton L,Barani IJ,Parsa AT

    更新日期:2012-01-01 00:00:00

  • Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replication.

    abstract::The results of assay for estrogen receptor (ER) in the tumor cytosol and thymidine labeling indices (TLI) of 63 primary invasive carcinomas of the breast were analyzed. The ER assay was performed by using dextran-charcoal to adsorb unbound tritiated estradiol-17beta (E2) in cytosol. The TLI was measured as the number ...


    pub_type: 杂志文章


    authors: Meyer JS,Rao BR,Stevens SC,White WL

    更新日期:1977-11-01 00:00:00

  • Observations of serum trace elements in chronic lymphocytic leukemia.

    abstract::Serum trace elements (STE) were measured in 50 patients with chronic lymphocytic leukemia (CLL) and 100 normal subjects. Copper was higher in patients than in controls (1.50 +/- 0.06 versus 1.10 +/- 0.02 micrograms/ml, P less than 0.001), increased steadily from Stage 0 to Stage 4 (P = 0.002), and correlated with the ...


    pub_type: 杂志文章


    authors: Beguin Y,Brasseur F,Weber G,Bury J,Delbrouck JM,Roelandts I,Robaye G,Fillet G

    更新日期:1987-10-15 00:00:00

  • Superficial cerebral astrocytoma attached to dura. Report of six cases in infants.

    abstract::Reported are six cases of meningocerebral astrocytomas attached to dura, involving the superficial cortex, in infants under 1 year of age. They represent 1.25% of 483 intracranial tumors in infancy studied at the Children's Hospital in the last 12 years. Five were located in the frontal lobes, with variable extension ...


    pub_type: 杂志文章


    authors: Taratuto AL,Monges J,Lylyk P,Leiguarda R

    更新日期:1984-12-01 00:00:00

  • A study of 15 cases of primary mediastinal lymphoma of B-cell type.

    abstract::Fifteen cases of pure supradiapragmatic lymphoma with initial prominent antero-superior mediastinal involvement displaying a B-cell pattern of reactivity were studied. These cases occurred in six men and nine women with a median age of 33 years at diagnosis (range, 23 to 75 years). Supradiapragmatic peripheral lymphad...


    pub_type: 杂志文章


    authors: Lavabre-Bertrand T,Donadio D,Fegueux N,Jessueld D,Taib J,Charlier D,Rousset T,Emberger JM,Baldet P,Navarro M

    更新日期:1992-05-15 00:00:00

  • Racial disparities in the use of and indications for colorectal procedures in Medicare beneficiaries.

    abstract:BACKGROUND:African Americans are diagnosed more frequently with colorectal carcinoma at a later stage compared with Caucasians. One potential reason for the disparity is a lower rate of screening examinations. METHODS:Using Outpatient and Physician-Supplier claims for all Medicare beneficiaries age > or = 65 years in ...


    pub_type: 杂志文章


    authors: Cooper GS,Koroukian SM

    更新日期:2004-01-15 00:00:00

  • The impact of underinsurance on bladder cancer diagnosis, survival, and care delivery for individuals under the age of 65 years.

    abstract:BACKGROUND:Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. METHODS:The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to iden...


    pub_type: 杂志文章


    authors: Fletcher SA,Cole AP,Lu C,Marchese M,Krimphove MJ,Friedlander DF,Mossanen M,Kilbridge KL,Kibel AS,Trinh QD

    更新日期:2020-02-01 00:00:00

  • Autoradiographic and fluorescent staining studies of bone marrow chromosomes from a patient with acute granulocytic leukemia.

    abstract::Results of cytogenetic studies of a patient with acute granulocytic leukemia are described. The modal number of chromosomes in cells from bone marrow samples was 43; the karyotype was characterized by missing chromosomes in groups B, C, and E. According to successive studies of the same metaphases by fluorescent stain...


    pub_type: 杂志文章


    authors: Sofuni T,Okada H

    更新日期:1975-02-01 00:00:00

  • Clinically ascertained health outcomes, quality of life, and social attainment among adult survivors of neuroblastoma: A report from the St. Jude Lifetime Cohort.

    abstract:BACKGROUND:The objective of this study was to characterize chronic disease, health-related quality of life (HRQOL), emotional distress, and social attainment among long-term survivors of neuroblastoma. METHODS:Chronic health conditions among 136 ≥10-year neuroblastoma survivors (median age, 31.9 years; range, 20.2-54....


    pub_type: 杂志文章


    authors: Wilson CL,Brinkman TM,Cook C,Huang S,Hyun G,Green DM,Furman WL,Bhakta N,Ehrhardt MJ,Krasin MJ,Robison LL,Ness KK,Hudson MM

    更新日期:2020-03-15 00:00:00

  • Is the N1c category of the new American Joint Committee on cancer staging system applicable to patients with rectal cancer who receive preoperative chemoradiotherapy?

    abstract:BACKGROUND:Pericolorectal tumor deposits (TDs) are associated with adverse outcomes in patients with colorectal cancer, and the seventh edition of the American Joint Committee on Cancer (AJCC) staging system recently classified TDs without regional lymph node metastasis as category N1c. However, the definition of TDs h...


    pub_type: 杂志文章


    authors: Song JS,Chang HJ,Kim DY,Kim SY,Baek JY,Park JW,Park SC,Choi HS,Oh JH

    更新日期:2011-09-01 00:00:00

  • Castleman's disease in POEMS syndrome with elevated interleukin-6.

    abstract::POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name "peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions." Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lym...


    pub_type: 杂志文章


    authors: Mandler RN,Kerrigan DP,Smart J,Kuis W,Villiger P,Lotz M

    更新日期:1992-06-01 00:00:00

  • Resection of brain metastases from colorectal carcinoma in 73 patients.

    abstract:BACKGROUND:At the time of diagnosis of colorectal carcinoma, 2-3% of patients are likely to be harboring brain metastases, and another 10% of patients will develop brain lesions during the course of their disease. The purpose of this study was to examine the clinical course of a group of patients with metastatic brain ...


    pub_type: 杂志文章


    authors: Wroński M,Arbit E

    更新日期:1999-04-15 00:00:00

  • MET amplification is not rare and predicts unfavorable clinical outcomes in patients with recurrent/metastatic gastric cancer after chemotherapy.

    abstract:BACKGROUND:Several large studies have reported an extremely low incidence of MET gene amplification (GA) in patients with radically resected gastric cancer. This study was conducted to evaluate the prevalence and prognostic role of MET in patients with recurrent=metastatic gastric cancer who received chemotherapy. MET...


    pub_type: 杂志文章


    authors: An X,Wang F,Shao Q,Wang FH,Wang ZQ,Wang ZQ,Chen C,Li C,Luo HY,Zhang DS,Xu RH,Li YH

    更新日期:2014-03-01 00:00:00

  • Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor.

    abstract:BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...


    pub_type: 杂志文章


    authors: Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

    更新日期:2011-11-01 00:00:00

  • Receipt of cancer screening procedures among Hispanic and non-Hispanic health maintenance organization members.

    abstract:BACKGROUND:Hispanic Americans have been shown to receive fewer cancer screening procedures than nonminority populations. Although lack of insurance or a regular source of care appear to be important determinants, cultural factors also have been suggested. This study examines whether Hispanic patients receive cancer scr...


    pub_type: 杂志文章


    authors: Jacobs EA,Lauderdale DS

    更新日期:2001-01-01 00:00:00

  • Clinical and biochemical effects in vivo of monoclonal antitumor antibody in Verner-Morrison's syndrome.

    abstract:BACKGROUND:Monoclonal antibodies have not been evaluated in metastasizing endocrine tumors, even though these lesions may induce severe morbidity of hormone excess in absence of considerable tumor burden. METHODS:A murine monoclonal antibody of the IgG2a subtype was generated by immunization with dispersed tumor cells...


    pub_type: 临床试验,杂志文章


    authors: Juhlin C,Papanicolaou V,Arnberg H,Klareskog L,Lörelius LE,Rastad J,Oberg K,Akerström G

    更新日期:1994-03-01 00:00:00

  • Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 function. The authors hypothesized that p53 codon 72 polymorphism may b...


    pub_type: 杂志文章


    authors: Li F,Sturgis EM,Chen X,Zafereo ME,Wei Q,Li G

    更新日期:2010-05-15 00:00:00

  • Cancer incidence in Norwegian Seventh-Day Adventists 1961 to 1986. Is the cancer-life-style association overestimated?

    abstract::Standardized incidence ratio for cancer in Norwegian Seventh-Day Adventists compared with the general population was not significantly different from unity (men 91, women 97). Persons converting late in life had a higher incidence than those converting at an earlier age. Respiratory cancers (standardized incidence rat...


    pub_type: 杂志文章


    authors: Fønnebø V,Helseth A

    更新日期:1991-08-01 00:00:00

  • High-dose combination chemotherapy for acute nonlymphoblastic leukemia in adults.

    abstract::One hundred thirty-nine consecutive unselected adults with acute nonlymphoblastic leukemia were treated with a high-dose chemotherapeutic remission-induction regimen consisting of daunomycin (70 mg/m2 IV on days 1, 2, 3), cytosine arabinoside (100 mg/m2 IV every 12 hours), 6-thioguanine (100 mg/m2 orally every 12 hour...


    pub_type: 临床试验,杂志文章


    authors: Glucksberg H,Cheever MA,Farewell VT,Fefer A,Sale GE,Thomas ED

    更新日期:1981-09-01 00:00:00

  • Tailoring smoking cessation for older adults.

    abstract:BACKGROUND:Older adults are an important audience for smoking cessation programs. Over 4.5 million older adults (older than 65) continue to smoke, and the majority are long term, heavy smokers. There is evidence that smoking cessation programs tailored to older smokers can be effective. American Cancer Society (ACS) ma...


    pub_type: 杂志文章


    authors: Rimer BK,Orleans CT

    更新日期:1994-10-01 00:00:00

  • Radition therpay control of nine patients with malignant thymoma.

    abstract::Malignant thymoma is a relatively rare condition and a review of the literature reveals approximately 100 reported cases. Only a small percentage of these have been treated with megavoltage radiation therapy; therefore, it is difficult to find the necessary information to establish a proper time-dose relationship for ...


    pub_type: 杂志文章


    authors: Marks RD Jr,Wallace KM,Pettit HS

    更新日期:1978-01-01 00:00:00

  • Thyroid medullary carcinoma with thyroglobulin immunoreactivity in sporadic multiple endocrine neoplasia type 2-B.

    abstract:BACKGROUND:Thyroid carcinomas historically have been divided into two groups according to their presumedly separate embryonic origins: those of neuroectodermal derivation (parafollicular or medullary carcinoma [MCT]) and those of foregut endodermal origin (follicular and papillary carcinomas). The validity of this conc...


    pub_type: 杂志文章


    authors: Kovacs CS,Masé RM,Kovacs K,Nguyen GK,Chik CL

    更新日期:1994-08-01 00:00:00

  • Lobular carcinoma arising in fibroadenoma of the breast.

    abstract::Lobular carcinoma may arise within the epithelial component of fibroadenoma of the breast, as evidenced by 5 cases reported from the files of the Mayo Clinic and 21 cases cited in the literature. The 5 cases reported here occurred in a series of 4000 cases of fibroadenoma during a 43-year period. Lobular carcinoma is ...


    pub_type: 杂志文章


    authors: Buzanowski-Konakry K,Harrison EG Jr,Payne WS

    更新日期:1975-02-01 00:00:00

  • Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients.

    abstract:BACKGROUND:Early stage lung cancer has a variable prognosis, and there are currently no markers that predict which patients will recur. This study examined the relation between tumor-regulatory T (Treg) cells and total tumor-infiltrating T-cell lymphocytes (TIL) to determine whether they correlated with recurrence. ME...


    pub_type: 杂志文章


    authors: Petersen RP,Campa MJ,Sperlazza J,Conlon D,Joshi MB,Harpole DH Jr,Patz EF Jr

    更新日期:2006-12-15 00:00:00

  • Marrow neutrophil reserve after adjuvant chemotherapy for carcinoma of the breast.

    abstract::The hematologic factors of 16 female patients with breast carcinoma who had received adjuvant chemotherapy with L-phenylalanine-based programs for two years were compared with those for 13 normal female volunteers of similar age. The findings include significant suppression of the mean hemoglobin level, of leukocyte c...


    pub_type: 杂志文章


    authors: Corder MP,Jochimsen PR

    更新日期:1982-06-15 00:00:00

  • Myeloma of the head of the pancreas. A case report.

    abstract::A 45-year-old man was diagnosed with multiple myeloma, IgA-kappa, in 1975. Thirteen years later he presented with obstructive jaundice. Computed tomography (CT) showed a 6-cm mass in the head of the pancreas. Needle aspiration showed myeloma. The jaundice resolved after treatment with radiotherapy. Extraosseous involv...


    pub_type: 杂志文章


    authors: Fischer A,Suhrland MJ,Vogl SE

    更新日期:1991-02-01 00:00:00