Abstract:
:A bolus intravenous dose of 5-fluorouracil of 600 mg/M2 was added exactly 1 hour after methotrexate administration in an established combination program including bleomycin and cisplatin for advanced squamous cell cancer of the head and neck. Results were no better than those observed previously with the three drugs, and hematologic and mucosal toxicities were slightly worse. The overall response rate was 41% in 34 patients with recurrent or metastatic disease, with only 6% complete remissions. Median time to disease progression for responding patients was 14 weeks, compared with 10 weeks for nonresponders. Partial response had little impact on survival. Among 12 patients with far-advanced disease confined above the clavicles without prior radiotherapy, 9 (75%) achieved partial remission, but the median survival, even with later surgery or irradiation, was only 34 weeks.
journal_name
Cancerjournal_title
Cancerauthors
Vogl SE,Komisar A,Kaplan BH,Engstrom PF,Kasule OH,Stolbach L,Lerner H,Muggia Fdoi
10.1002/1097-0142(19860215)57:4<706::aid-cncr28205subject
Has Abstractpub_date
1986-02-15 00:00:00pages
706-10issue
4eissn
0008-543Xissn
1097-0142journal_volume
57pub_type
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