Sequential methotrexate and 5-fluorouracil with bleomycin and cisplatin in the chemotherapy of advanced squamous cancer of the head and neck.

Abstract:

:A bolus intravenous dose of 5-fluorouracil of 600 mg/M2 was added exactly 1 hour after methotrexate administration in an established combination program including bleomycin and cisplatin for advanced squamous cell cancer of the head and neck. Results were no better than those observed previously with the three drugs, and hematologic and mucosal toxicities were slightly worse. The overall response rate was 41% in 34 patients with recurrent or metastatic disease, with only 6% complete remissions. Median time to disease progression for responding patients was 14 weeks, compared with 10 weeks for nonresponders. Partial response had little impact on survival. Among 12 patients with far-advanced disease confined above the clavicles without prior radiotherapy, 9 (75%) achieved partial remission, but the median survival, even with later surgery or irradiation, was only 34 weeks.

journal_name

Cancer

journal_title

Cancer

authors

Vogl SE,Komisar A,Kaplan BH,Engstrom PF,Kasule OH,Stolbach L,Lerner H,Muggia F

doi

10.1002/1097-0142(19860215)57:4<706::aid-cncr28205

subject

Has Abstract

pub_date

1986-02-15 00:00:00

pages

706-10

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

57

pub_type

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