Evaluation of a protective environment in the management of granulocytopenic patients: a comparative study.

Abstract:

:Fever, clinical infection, bacteriologically documented infection, and death from infection were evaluated in 95 consecutive uninfected patients with severe granulocytopenia (less than 0.5 x 10(6)/liter). Patients were randomly allocated to reverse isolation and prophylactic oral nonabsorbable antibiotics or to open ward care. The microbiologic surveillance of air samples and stool cultures showed reduction of pathogenic organisms in patients treated in protective environment units. There was a statistically significant reduction in the incidence of fever (80% vs. 39.6%; P less than 0.001), clinical infections (55.3% vs. 25%; P less than 0.01), bacteriologically documented infections (53.2% vs. 20.8%; P less than 0.01), and deaths from infections (25.5% vs. 8.3%; P = 0.02) in patients treated in a protective environment as compared with patients treated on the open ward.

journal_name

Cancer

journal_title

Cancer

authors

Ribas-Mundo M,Granena A,Rozman C

doi

10.1002/1097-0142(19810715)48:2<419::aid-cncr28204

subject

Has Abstract

pub_date

1981-07-15 00:00:00

pages

419-24

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

48

pub_type

临床试验,杂志文章,随机对照试验

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