Abstract:
:Fever, clinical infection, bacteriologically documented infection, and death from infection were evaluated in 95 consecutive uninfected patients with severe granulocytopenia (less than 0.5 x 10(6)/liter). Patients were randomly allocated to reverse isolation and prophylactic oral nonabsorbable antibiotics or to open ward care. The microbiologic surveillance of air samples and stool cultures showed reduction of pathogenic organisms in patients treated in protective environment units. There was a statistically significant reduction in the incidence of fever (80% vs. 39.6%; P less than 0.001), clinical infections (55.3% vs. 25%; P less than 0.01), bacteriologically documented infections (53.2% vs. 20.8%; P less than 0.01), and deaths from infections (25.5% vs. 8.3%; P = 0.02) in patients treated in a protective environment as compared with patients treated on the open ward.
journal_name
Cancerjournal_title
Cancerauthors
Ribas-Mundo M,Granena A,Rozman Cdoi
10.1002/1097-0142(19810715)48:2<419::aid-cncr28204subject
Has Abstractpub_date
1981-07-15 00:00:00pages
419-24issue
2eissn
0008-543Xissn
1097-0142journal_volume
48pub_type
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