Abstract:
:The clinical findings in 262 patients with melanoma were correlated with an assessment of their cellular-mediated immunity by delayed-type hypersensitivity (DTH) skin tests, by lymphocyte blastogenesis, and by leukocyte enumerations. Patients with systemic metastases (stage IV) and those with evidence of tumor burden had fewer positive DTH reactions for recall antigens than did patients with localized disease (stage I), patients with no evidence of tumor burden, and 227 normal controls. However, no differences were found in the magnitude of response among patients with melanoma or when compared with controls. Patients with melanoma had fewer responses to dinitrochlorobenzene (40% than did controls (98%), but there were no differences by stage or tumor burden. Similarly, blastogenesis in the presence of PHA, Con A, and PWM was depressed when compared with controls, but there was no meaningful correlation with the clinical status. Leukocyte, T cell, or B cell counts revealed no alteration from normal for the patients with melanoma. The usefulness of these studies for routine clinical monitoring is questioned.
journal_name
Cancerjournal_title
Cancerauthors
Pritchard DJ,Ritts RE Jr,Taylor WF,Miller GCdoi
10.1002/1097-0142(197806)41:6<2165::aid-cncr282041subject
Has Abstractpub_date
1978-06-01 00:00:00pages
2165-73issue
6eissn
0008-543Xissn
1097-0142journal_volume
41pub_type
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