Abstract:
:The feasibility of employing adjuvant topical mechlorethamine after electron beam therapy in the treatment of patients with mycosis fungoides is demonstrated. Patients treated with a planned adjuvant topical mechlorethamine schedule had a median disease-free interval of 25 months compared to 17 months for the group treated with electron beam therapy alone. Projected relapse-free survivals are slightly better in the adjuvant group--37% versus 29%. Patients receiving adjuvant topical mechlorethamine after the electron beam were observed to have a low incidence of contact allergy to the medication. The topical medication can be continued if a contact allergy develops by using a planned desensitization program. We currently treat all mycosis fungoides patients with electron beam therapy, randomizing half to receive adjuvant topical mechlorethamine.
journal_name
Cancerjournal_title
Cancerauthors
Price NM,Hoppe RT,Constantine VS,Fuks ZY,Farber EMdoi
10.1002/1097-0142(197712)40:6<2851::aid-cncr282040subject
Has Abstractpub_date
1977-12-01 00:00:00pages
2851-3issue
6eissn
0008-543Xissn
1097-0142journal_volume
40pub_type
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