Abstract:
BACKGROUND:Gastric mucosal blood flow, secretion of mucin, and renewal of the gastric mucosal cells are considered to be defensive factors against gastric mucosal injuries. These factors are regulated by the nervous system and neuropeptides. Gastrectomy may affect this regulation and induce gastric mucosal changes, such as atrophic gastritis and carcinoma. The effects of denervation of the gastric mucosa on tumorigenesis of the remnant stomach were investigated. METHODS:Using male Wistar rats, four groups of Billroth I (B-I)gastrectomy, Billroth II (B-II) gastrectomy, and those with denervation were conducted. Subdiaphragmatic truncal vagotomy was performed in the denervated group. Thirty weeks after the operations, histologic examination and periodic acid-Schiff--Alcian blue (PAS-AB) staining of the gastric mucosa, analysis of cell kinetics of the gastric mucosa by immunohistochemistry of proliferating cell nuclear antigen, and measurement of intragastric pH, intragastric bile acid concentration, and serum gastrin levels were performed. No carcinogenic agents were given. RESULTS:The B-I group showed no remarkable gastric mucosal changes, but B-I with denervation showed a significant increase in the development of tumor (67%) and carcinoma (42%). In the B-II groups, the denervation induced a significant increase in tumorigenesis, from 22% to 58%. Analysis of cell kinetics revealed a significant increase of labeling index in those groups that developed tumors. PAS-AB staining showed a decrease of PAS positive mucin but an increase of acidic mucin-producing cells in the denervated groups, suggesting an increase in the number of immature cells that are more susceptible to atrophic gastritis and carcinoma. There was no close relationship between tumorigenesis and intragastric pH, intragastric bile acid concentration, or serum gastrin levels. CONCLUSIONS:After gastrectomy, not only duodenogastric reflux, but also the denervation of the gastric mucosa play an important role in the etiology of gastric remnant cancer.
journal_name
Cancerjournal_title
Cancerauthors
Kaminishi M,Shimizu N,Shiomoyama S,Yamaguchi H,Ogawa T,Sakai S,Kuramoto S,Oohara Tdoi
10.1002/1097-0142(19950315)75:6+<1490::aid-cncr282subject
Has Abstractpub_date
1995-03-15 00:00:00pages
1490-6issue
6 Suppleissn
0008-543Xissn
1097-0142journal_volume
75pub_type
杂志文章相关文献
CANCER文献大全abstract::Although Kaposi's sarcoma (KS) usually appears with solitary skin lesions, in a large percentage of these patients the disease progresses eventually to involve large extensive segments of the skin. In the past, the most frequently used approach is the irradiation of isolated lesions as they arose, hence the so-called ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810215)47:4<640::aid-cncr28204
更新日期:1981-02-15 00:00:00
abstract:BACKGROUND:Informed consent has been proposed as the optimal method for ensuring the ethical entry of patients into clinical trials. However, it is known that problems with informed consent exist from the perspective of both patients and physicians. This has led to the suggestion that a third party, such as a research ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10994
更新日期:2002-12-01 00:00:00
abstract::Census data indicate that Cambodian Americans are economically disadvantaged and linguistically isolated. In addition, cancer registry data show that Southeast Asians experience several cancer-related health disparities (e.g., markedly elevated risks of cervical and liver cancer). The Seattle regional Asian American N...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21515
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:Patients with prostate cancer receiving androgen deprivation therapy (ADT) are at risk of sleep disturbance; however, to the authors' knowledge, the mechanisms by which ADT may affect sleep are not well understood. The current study compared objective and subjective sleep disturbance in ADT recipients and co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31024
更新日期:2018-02-01 00:00:00
abstract::The objective of this study was to evaluate the sensitivity of two methods for determining bone marrow involvement with non-Hodgkin's lymphoma. These methods were histologic review of bone marrow aspirates, and clot sections versus in vitro growth of lymphoma colonies on soft agar. Forty-two bone marrow aspirates were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840415)53:8<1724::aid-cncr2820
更新日期:1984-04-15 00:00:00
abstract:BACKGROUND:Results from numerous trials have indicated that breast-conserving therapy (BCT) produces outcomes equivalent to those produced by mastectomy in terms of both locoregional control and survival. However, conservative treatment has resulted in the dilemma of how best to address recurrences when they appear in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22529
更新日期:2007-04-01 00:00:00
abstract::Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<245::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract:BACKGROUND:The recurrence or mortality rate of axillary lymph node-negative invasive breast cancer has been associated with the tumor S-phase fraction, which is measured by DNA flow cytometry. Because many of the studies that established this association were performed using frozen, pulverized tumor specimens, this ass...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930915)72:6<1926::aid-cncr2820
更新日期:1993-09-15 00:00:00
abstract::Since 1972 plasma CEA levels of 25 cancer patients have been assayed to evaluate the reliability of CEA as an early indicator of recurrent gastrointestinal cancer. Identification of significant elevations in CEA levels required definition of exactly what a given value meant. Intraassay and interassay accuracy was dete...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197702)39:2<440::aid-cncr2820390
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:: Although patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer (PanCa), the timely detection of PanCa often is difficult, because the symptoms of CP and PanCa are very similar. Moreover, secondary inflammation may be identified in PanCa, further complicating diagnosis. To impr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24893
更新日期:2010-04-01 00:00:00
abstract::Because Langerhans' cells (LC) (CD1a-positive epidermal cells) have been discussed to be involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the authors examined the influence of densities of Langerhans' cells and, concurrently, of other phenotypes retrospectively on survival of 35 patients. Cell de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900501)65:9<2069::aid-cncr2820
更新日期:1990-05-01 00:00:00
abstract::Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870401)59:7<1376::aid-cncr2820
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:Little is understood about the factors that influence survival in patients who undergo gamma-knife stereotactic radiosurgery (SRS) for brain metastases. METHODS:Demographic, disease, treatment, and survival data on 334 patients with intracranial metastases who underwent initial SRS from 1998 to 2004 were ab...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22367
更新日期:2007-01-01 00:00:00
abstract::Twelve patients with pulmonary neoplasms treated at the Fox Chase Cancer Center were found to have a syndrome of axillary-subclavian vein occlusion. Ten patients had non-small-cell lung carcinoma, one had small cell carcinoma, and one had mesothelioma. In eight patients, this vascular syndrome developed as a consequen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811015)48:8<1886::aid-cncr2820
更新日期:1981-10-15 00:00:00
abstract::Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800915)46:6<1401::aid-cncr2820
更新日期:1980-09-15 00:00:00
abstract::The entire colonic mucosa of 51 cases of colorectal carcinoma was examined histologically. Mucosal lesions including goblet cell hyperplasia, crypt dilatation, ulceration with regeneration, basal cell hyperplasia, metaplastic lesions, and adenomas were encountered. Goblet cell hyperplasia (80.4%) was most prominent ad...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1988-04-15 00:00:00
abstract:BACKGROUND:To the authors' knowledge, outcomes and prognostic tools have yet to be clearly defined in patients with metastatic renal cell carcinoma (mRCC) who are treated with immuno-oncology (IO) checkpoint inhibitors (programmed death-ligand 1 [PD-L1] inhibitors). In the current study, the authors aimed to establish ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.31595
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25099
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Patients age > or = 75 years with acute myeloid leukemia (AML) generally are offered palliative treatments instead of induction chemotherapy. The authors conducted a retrospective study comparing the outcomes among these elderly patients with the outcomes among younger patients to assess the impact of intens...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20353
更新日期:2004-07-15 00:00:00
abstract::Seventy-eight patients with metastatic cancer to the lungs underwent flexible fiberoptic bronchoscopy for diagnosis. The patients were divided into two groups by presenting radiographic pattern as: (I) diffuse linear interstitial infiltrations (55 patients); and (II) localized or multiple nodular opacities (23 patient...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831115)52:10<1949::aid-cncr282
更新日期:1983-11-15 00:00:00
abstract:BACKGROUND:Ifosfamide has previously been shown to be active as a single agent and in combination with doxorubicin, etoposide, and teniposide in pediatric solid tumors and adult acute leukemia. The authors performed a dose-escalation trial of ifosfamide with a fixed dosage of etoposide, with mesna uroprotection, in chi...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19930901)72:5<1790::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:This study was performed to clarify the clinicopathologic features of hepatocellular carcinoma (HCC) patients surviving >10 years after hepatic resection. METHODS:Between January 1971 and April 1987, 142 patients underwent hepatic resection. Thirty-nine patients who died of surgical morbidity (surgical mort...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860201)57:3<558::aid-cncr28205
更新日期:1986-02-01 00:00:00
abstract::This survey of the incidence of melanoma in New South Wales, Australia, from 1970 to 1976 revealed a doubling of incidence in the seven year period. The most marked rise occurred in 1972. A marked preponderance of leg melanoma in women and trunk melanoma in men was noted. The incidence of melanoma in men continues to ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800715)46:2<427::aid-cncr28204
更新日期:1980-07-15 00:00:00
abstract::Etoposide underwent conventional Phase I testing in the 1970s. The dose-limiting toxicity in these studies was mild myelosuppression; other toxicities were infrequent. If a greater degree of myelosuppression is accepted, higher than standard doses could be given. This approach takes advantage of the steep dose-respons...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910101)67:1+<292::aid-cncr2820
更新日期:1991-01-01 00:00:00
abstract::A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840715)54:2<367::aid-cncr28205
更新日期:1984-07-15 00:00:00
abstract::Serum trace elements (STE) were measured in 50 patients with chronic lymphocytic leukemia (CLL) and 100 normal subjects. Copper was higher in patients than in controls (1.50 +/- 0.06 versus 1.10 +/- 0.02 micrograms/ml, P less than 0.001), increased steadily from Stage 0 to Stage 4 (P = 0.002), and correlated with the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871015)60:8<1842::aid-cncr2820
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31395
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults. Temozolomide was rapidly incorporated into first-line treatment following the publication of the pivotal European Organization for Research and Treatment of Cancer-National Cancer Institute of Canada phase 3 trial in 2005. Howe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26685
更新日期:2012-09-01 00:00:00
abstract::A summary is presented of those organ specific enzyme assays traditionally used in evaluation of the patient with cancer. In addition, the use of certain serum enzymes such as gamma-glutamyl transpeptidase, phosphohexose isomerase or 5'-nucleotidase as aids in following the course of the disease, particularly in patie...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197601)37:1+<542::aid-cncr282037
更新日期:1976-01-01 00:00:00