Abstract:
:The combination of cisplatin, vinblastine, and bleomycin (PVB) was used to treat a 25-year-old man for disseminated testicular germ cell cancer, leading to a complete remission. Acute nonlymphocytic leukemia (ANLL), resistant to chemotherapy, developed 5 years later. The secondary nature of this ANLL was corroborated by the detection of nonrandom chromosomal aberrations in bone marrow cells of chromosomes, 7, 5, and 3. This is one of the first reports of possible leukemogenic activity of PVB treatment when applied without additional irradiation or alkylating agents.
journal_name
Cancerjournal_title
Cancerauthors
van Imhoff GW,Sleijfer DT,Breuning MH,Anders GJ,Mulder NH,Halie MRdoi
10.1002/1097-0142(19860301)57:5<984::aid-cncr28205subject
Has Abstractpub_date
1986-03-01 00:00:00pages
984-7issue
5eissn
0008-543Xissn
1097-0142journal_volume
57pub_type
杂志文章相关文献
CANCER文献大全abstract::The prognostic significance of objectively measured karyometric variables (ploidy pattern, nuclear roundness, area, elongation, chromatin texture, and nearest nucleus distance) was investigated in relation to clinical (stage and type of disease) and morphologic (histologic patterns) variables in 27 patients with the d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900515)65:10<2255::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract:BACKGROUND:Accurate assessment of HER-2 status is necessary prior to anti-HER-2 antibody (trastuzumab) therapy for metastatic breast carcinoma. However, controversy exists regarding whether to assess HER-2 status in the primary tumor or in metastatic lesions. It is also unclear whether HER-2 status can change during di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20987
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:In various neoplasms expression of the proliferation-related Ki-67 antigen has successfully been linked with parameters of progression of disease. While a definite grading scheme for oligodendrogliomas has still not been agreed upon, any parameter of tumor proliferation that might be helpful in predicting cl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960901)78:5<1107::AID-CN
更新日期:1996-09-01 00:00:00
abstract::Histologic groups in 231 cases of malignant lymphoma were correlated with survival data at 100 months from the time of initiation of the study. Patients in the first two decades of life fared comparably with adults, but those over 60 years of age showed a poorer survival trend. Seven favorable and four unfavorable his...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810615)47:12<2894::aid-cncr282
更新日期:1981-06-15 00:00:00
abstract::To collect an unselected total bronchial carcinoma population as a basis for randomized therapy studies during 1971-1976, 537 patients with suspected bronchial carcinoma were investigated. Of these, 109 were found to have an adenocarcinoma in the lung. Of the 109, 10 had been initially diagnosed as not having adenocar...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19811101)48:9<2121::aid-cncr2820
更新日期:1981-11-01 00:00:00
abstract::Malignant fibrous histiocytoma of soft tissues (MFH), a mesenchymal tumor of varied morphologic patterns and cell types, sometimes contains bone and cartilage. Such bony and cartilaginous elements in a pleomorphic MFH may pose a difficult diagnostic challenge. An MFH with bone and cartilage can be distinguished from e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820201)49:3<480::aid-cncr28204
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Kaiser Permanente (KP) is a large health maintenance organization (HMO) operating in 14 states and caring for 8,000,000 members in hundreds of facilities staffed by thousands of physicians and support personnel. Cancer care is provided to these KP members as part of the health care package. METHODS:KP insur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980515)82:10+<2076::aid-
更新日期:1998-05-15 00:00:00
abstract::Data on patients with gallbladder cancer listed in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute were reviewed. Between 1977 and 1986, 3038 patients were recorded in the Program. Histologic grade, histologic type, stage of disease, and vascular invasion were correlated...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920915)70:6<1493::aid-cncr2820
更新日期:1992-09-15 00:00:00
abstract::The anniversary of the first publication of Cancer provides an opportunity to review the progress in liver cancer surgery in the past 60 years. Indeed, the past half century has been witness to remarkable advances in liver surgery that have provided benefit to so many patients afflicted with primary or secondary liver...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23652
更新日期:2008-10-01 00:00:00
abstract::The morphologic features, phenotype, and functions of OKM1+ leukemic T-cells were studied. The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic character...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860415)57:8<1507::aid-cncr2820
更新日期:1986-04-15 00:00:00
abstract::Forty seven patients with early gastric cancer received a 30-minute intravenous injection of bromodeoxyuridine (BrdU), 1000 mg each 1 hour before laparotomy, to label tumor cells in the S phase. In 13 of 47 patients, specimens obtained by endoscopic biopsy were cultured in vitro at 37 degrees C for 1 hour under three ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891015)64:8<1665::aid-cncr2820
更新日期:1989-10-15 00:00:00
abstract::Eighteen patients with isolated vaginal recurrence of their previously treated endometrial carcinoma were treated with radiation therapy at North Carolina Baptist Hospital, Winston-Salem between 1971 and 1982. Most patients received external beam irradiation which were followed by boost treatments that were delivered ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870801)60:3<419::aid-cncr28206
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:The ability to divide subsets of patients with glial neoplasms into prognostic groups currently is limited because only a few clinical and pathologic variables are available. The goal of this investigation was to identify biologic factors of potential prognostic value in patients with cerebral gliomas. METH...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3<920::aid-cncr28207
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The development of new chelating agents and radiolabeling protocols is essential to progress in radioimmunotherapy with antibody-chelate conjugates. METHODS:Immunoconjugates of four polyazamacrocycles with N-bonded acetate groups were prepared by conjugation via 2-iminothiolane to Lym-1, a murine antilympho...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940201)73:3+<779::aid-cncr2820
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Amplification of DNA in certain chromosomal regions plays a crucial role in the development and progression of human malignancies, specifically when protooncogenic target genes within those amplicons are overexpressed. Comparative genomic hybridization studies have revealed frequent amplification at 20q in p...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11482
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Patients with gastric cancer have a poor prognosis and can be cured by surgery only if the cancer is detected in an early stage. Extended surgery, down staging with chemotherapy before operation, and new postoperative treatments are recent approaches to increase survival rates. Categorizing patients' prognos...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19960315)77:6<1035::aid-cn
更新日期:1996-03-15 00:00:00
abstract:BACKGROUND:The majority of patients with breast carcinoma with > or = 10 metastatic axillary lymph nodes (ALNs) develop recurrent disease within 5 years from diagnosis. The purpose of the current study, performed retrospectively, was to characterize the natural history of this subset of patients, both before and after ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.21182
更新日期:2005-07-15 00:00:00
abstract::To verify whether analysis of the levels of CA125, carcinoembryonic antigen (CEA), and CA19-9 in the cervical mucus is effective for a detection of cervical adenocarcinomas or not, simultaneous measurement of these three tumor markers in the cervical mucus samples from women without gynecologic disorders, with leiomyo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<541::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract::Metastatic tumors to the mucosa of the stomach are unusual occurrences that can cause clinical and pathologic problems in diagnosis. The authors report 67 cases from the files of the Veterans Administration Center at Houston. Ten cases were found on endoscopic biopsy and 57 at necropsy. Each patient endoscopically eva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900401)65:7<1596::aid-cncr2820
更新日期:1990-04-01 00:00:00
abstract::Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive pot...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.32069
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:As a result of a major social and demographic transition, Colombia is currently undergoing major changes in disease-specific mortality rates, including an increasing burden of cancer death. The current article described some aspects of the evolution of cancer mortality in Colombia and, in particular, highlig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20607
更新日期:2004-11-15 00:00:00
abstract:BACKGROUND:Patients with multiple myeloma (MM) have increased bone marrow angiogenesis, a low plasma cell labeling index, and multidrug resistance (the primary cause of chemotherapy failure). MM patients receiving the vincristine, doxorubicin, and dexamethasone (VAD) regimen develop resistance and cardiac and steroid t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.10946
更新日期:2002-11-15 00:00:00
abstract::The use of preoperative computed tomographic (CT) scans of the chest in carcinoma of the esophagus to associate preoperative staging with postoperative survival is controversial. Thirty-two patients who underwent esophagectomy and reconstruction were examined with respect to a variety of variables available on preoper...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881001)62:7<1287::aid-cncr2820
更新日期:1988-10-01 00:00:00
abstract::Meningeal myeloid metaplasia (MM) is very rarely observed in patients with myelofibrosis. We report the occurrence of meningeal MM causing exophthalmus and fever in a patient with myelofibrosis secondary to polycythemia vera. A computerized tomography (CT) scan showed multiple intracranial and intraorbital enhancing m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881201)62:11<2346::aid-cncr282
更新日期:1988-12-01 00:00:00
abstract::There are three principal disturbances in bone remodelling that occur in neoplasia affecting the skeleton. The first is an increase in bone turnover that in solid tumors may be confined to sites of metastases or be a generalized phenomenon, most likely related to the secretion of parathyroid hormone-related protein. I...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19971015)80:8+<1538::aid-c
更新日期:1997-10-15 00:00:00
abstract:BACKGROUND:The authors established the genotype frequencies of cytochrome P450 (CYP1A1/MspI, CYP2E1/PstI, and CYP2E1/DraI), glutathione-S-transferase (GSTM1 and GSTT1), and p53 (exon 4/AcclI and intron 3/16-base pair duplication) gene polymorphisms in cervical carcinoma patients and controls and evaluated the associati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000501)88:9<2082::aid-cn
更新日期:2000-05-01 00:00:00
abstract::A series of nine cases of radiation myelopathy seen at the University of California, San Francisco (UCSF) is reviewed, and their treatment data converted into nominal single doses (NSD) and equivalent single doses (ED). The 1% incidence level of myelopathy in the thoracic cord is 1015 rets (ED), and the 50% incidence...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197506)35:6<1558::aid-cncr282035
更新日期:1975-06-01 00:00:00
abstract::Monozygotic twins developed gastric cancers that were found almost simultaneously. A 47-year-old man complained of nausea and vomiting; an upper gastrointestinal series and endoscopy revealed advanced gastric cancer invading the serosa. Palliative subtotal gastrectomy was performed. In his asymptomatic twin a gastric ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19881201)62:11<2430::aid-cncr282
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:The authors have noted that in cervical cytology specimens from perimenopausal and postmenopausal women, the diagnosis of atypical squamous cells of undetermined significance (ASC-US), as defined in the Bethesda system, is often not associated with a clinically evident lesion on follow-up. Reflex human papil...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22687
更新日期:2007-06-25 00:00:00
abstract::Twenty-two patients with cancer of the colon and rectum were studied: preoperative and postoperative cell-mediated and humoral immune factors were assessed, and local concentration of immunoglobulins in tumor tissue and in normal mucosa were measured. Lymphocyte function was found to be reduced in 50% of stage A and B...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800815)46:4<700::aid-cncr28204
更新日期:1980-08-15 00:00:00