Acute nonlymphocytic leukemia 5 years after treatment with cisplatin, vinblastine, and bleomycin for disseminated testicular cancer.

Abstract:

:The combination of cisplatin, vinblastine, and bleomycin (PVB) was used to treat a 25-year-old man for disseminated testicular germ cell cancer, leading to a complete remission. Acute nonlymphocytic leukemia (ANLL), resistant to chemotherapy, developed 5 years later. The secondary nature of this ANLL was corroborated by the detection of nonrandom chromosomal aberrations in bone marrow cells of chromosomes, 7, 5, and 3. This is one of the first reports of possible leukemogenic activity of PVB treatment when applied without additional irradiation or alkylating agents.

journal_name

Cancer

journal_title

Cancer

authors

van Imhoff GW,Sleijfer DT,Breuning MH,Anders GJ,Mulder NH,Halie MR

doi

10.1002/1097-0142(19860301)57:5<984::aid-cncr28205

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

984-7

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

57

pub_type

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