Abstract:
BACKGROUND:Both paclitaxel and mitoxantrone demonstrate significant antineoplastic activity in breast cancer patients. Colony stimulating factor support allows significant dose escalation of each of these drugs when administered as a single agent. METHODS:We performed a Phase I study employing escalating doses of paclitaxel and mitoxantrone with granulocyte-macrophage colony stimulating factor (GM-CSF) support. Initially the paclitaxel dose was fixed at 175 mg/m2 and an attempt was made to escalate mitoxantrone from the starting dose of 14 mg/m2. Subsequently, the dose of mitoxantrone was fixed at 14 mg/m2 and the dose of paclitaxel was increased. Treatments were given every three weeks. RESULTS:In neither case could we safely escalate beyond a combination of paclitaxel 175 mg/m2 and mitoxantrone 14 mg/m2 which is, therefore, the recommended Phase II dose. The dose limiting toxicity was neutropenia. No unexpected toxicities were observed, although two patients were removed from the study because of chest pain possibly related to GM-CSF. There were no complete or partial remissions. CONCLUSIONS:We conclude that GM-CSF does not allow significant dose escalation of this combination of agents.
journal_name
Cancerjournal_title
Cancerauthors
Fleming GF,Janisch L,Vogelzang NJ,Vokes EE,Ratain MJdoi
10.1002/(SICI)1097-0142(19960601)77:11<2308::AID-Csubject
Has Abstractpub_date
1996-06-01 00:00:00pages
2308-12issue
11eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19960601)77:11<2308::AID-Cjournal_volume
77pub_type
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