Abstract:
BACKGROUND:Androgen receptor blocking agents have become an established form of therapy for men with disseminated prostate carcinoma. The purpose of this study was to evaluate markers of bone turnover and to measure bone mineral densities (BMD) in men with disseminated prostate carcinoma treated with combined androgen blockade prior to and after 6 months of intermittent cyclic etidronate therapy. METHODS:Twelve consecutive men with disseminated prostate carcinoma were evaluated at 0, 6, and 12 months after treatment with a long acting gonadotropin-releasing hormone agonist (goserelin acetate) and an androgen antagonist (flutamide). During the 6-12 month period, patients were treated with adjuvant intermittent cyclic etidronate therapy and calcium supplementation. Lumbar spine BMD was measured by spinal quantitative computed tomography (QCT) and femoral neck BMD by dual energy X-ray absorptiometry (DXA). RESULTS:Combined androgen blockade resulted in all men achieving serum free testosterone concentrations of <2.2 pmol/L (normal range, 38-114 pmol/ L). The mean serum prostate specific antigen activities decreased from 130.8+/-46 to 6.9+/-4.4 ng/mL (P < 0.05). Although serum calcium, parathyroid hormone, and 25-hydroxyvitamin D measurements remained unchanged, serum bone Gla-protein concentrations and urinary deoxypyridinolene excretion rates increased significantly (P < 0.01, respectively). Mean lumbar spine QCT decreased by 6.6+/-1.5% from 76.5 mg/cm3 (95% confidence interval [95% CI, 57-96 mg/cm3) to 73.9 mg/cm3 (95% CI, 55-93 mg/cm3) (P < 0.001) and mean femoral neck DXA decreased by 6.5+/-1.3% from 0.94 g/cm2 (95% CI, 0.81-1.07 g/cm2) to 0.91 g/cm2 (95% CI, 0.79-1.04 g/cm2) (P < 0.001). After treatment with adjuvant intermittent cyclic etidronate, mean lumbar spine QCT increased by 7.8+/-3.7% to a final value of 75 mg/cm3 (95% CI, 48.7-101 mg/cm3) (P=0.001 compared with the initial 6 months without intermittent cyclic etidronate therapy). Significant increases in BMD also were observed in the femoral neck and Ward's triangle. CONCLUSIONS:Androgen receptor blocking agents have an established role in the treatment of disseminated prostate carcinoma. However, combined androgen blockade in elderly men with disseminated prostate carcinoma results in high bone turnover with significant cancellous bone loss. The results of this study show that adjuvant therapy with intermittent cyclic etidronate may prevent these changes and decrease the risk of spinal fractures.
journal_name
Cancerjournal_title
Cancerauthors
Diamond T,Campbell J,Bryant C,Lynch Wsubject
Has Abstractpub_date
1998-10-15 00:00:00pages
1561-6issue
8eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19981015)83:8<1561::AID-CNjournal_volume
83pub_type
杂志文章相关文献
CANCER文献大全abstract::Fifty-nine colorectal carcinomas of patients with verified cancer family syndrome (CFS) were analyzed for DNA ploidy using flow cytometry. Sixty-eight percent of the tumors were diploid, and 32% were aneuploid. The aneuploid tumors had a median DNA index of 1.24 (range, 1.12-1.97). In 90% of all tumors the DNA index w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900415)65:8<1825::aid-cncr2820
更新日期:1990-04-15 00:00:00
abstract:BACKGROUND:The authors compared the relative efficacy and safety of low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) for the initial treatment of venous thromboembolism (VTE) between patients with and without cancer. METHODS:By using Cochrane methodology for systematic reviews, separate meta-analys...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23814
更新日期:2008-10-01 00:00:00
abstract::Two hundred seventy-nine consecutive patients with Stage II osteogenic sarcoma of the appendicular skeleton treated between 1976 and 1986 were studied to identify predictors of long-term survival. Survival was 77% and 73% at 5 and 10 years, respectively, with continuously disease-free survival being 70% and 69%. On un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920201)69:3<698::aid-cncr28206
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.23689
更新日期:2008-09-15 00:00:00
abstract::Histologic examination of bone-marrow from the posterior iliac crest was routinely done as a pretreatment staging procedure in 203 consecutive patients with small-cell anaplastic carcinoma of the lung. Subtyping of the patients according to the WHO classification included 27.8% with "fusiform" cell type (WHO II,1), 28...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197706)39:6<2563::aid-cncr282039
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:RAS/RAF/mitogen-activated protein kinase activation is common in myeloid malignancies. Trametinib, a mitogen-activated protein kinase kinase 1 (MEK1)/MEK2 inhibitor with activity against multiple myeloid cell lines at low nanomolar concentrations, was evaluated for safety and clinical activity in patients wi...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.29986
更新日期:2016-06-15 00:00:00
abstract:BACKGROUND:The runt-related transcription factor RUNX3 plays essential roles in various types of tumors, including gastric cancer. Epigenetic changes in the methylation of the RUNX3 proximal promoter, but not common genetic changes in RUNX3, have been associated with both changes in the gene expression and development ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26161
更新日期:2011-11-15 00:00:00
abstract:BACKGROUND:US breast cancer mortality is declining, but thousands of women still die each year. METHODS:Two established simulation models examine 6 strategies that include increased screening and/or treatment or elimination of obesity versus continuation of current patterns. The models use common national data on inci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28087
更新日期:2013-07-15 00:00:00
abstract::Pleural fluid and serum protein electrophoresis and quantitative immunoglobulin measurements were carried out in patients with pleural effusions. The mean pleural fluid/serum ratios of IgA, IgG, and IgM were elevated in patients with malignant pleural effusions compared with patients with nonmalignant pleural effusion...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831201)52:11<2151::aid-cncr282
更新日期:1983-12-01 00:00:00
abstract::A case of thymoma in a 12-year-old boy is presented. The patient had a history of thymic irradiation in infancy, and a family history of leukemia. The mass was readily resected and the patient is well 10 years later. The tumor contained an unusual admixture of normal thymic tissue with the neoplastic epithelial elemen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<953::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract::A controlled trial of surgical adjuvant chemotherapy for breast cancer was carried out using 551 Japanese patients. Single or combined treatment with mitomycin C (0.2 mg/kg i.v. three times within five days postoperatively) and cyclophosphamide (100 mg postoperatively daily for four months or longer) was used after ra...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19801201)46:11<2373::aid-cncr282
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Expression of oncofetal fibronectin (oncFN) and normal fibronectin (norFN) in colorectal cancer specimens was examined to investigate the correlation between fibronectin localization and histologic grade, liver metastasis, and prognosis. METHODS:Immunohistochemical staining of oncFN and norFN was performed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950615)75:12<2802::aid-cncr282
更新日期:1995-06-15 00:00:00
abstract:BACKGROUND:Leptomeningeal disease (LMD) involves the spread of malignant cells from solid tumors to the cerebrospinal fluid or to the leptomeninges. LMD has a very poor prognosis and it is difficult to diagnose and follow with traditional diagnostic tools. The purposes of this study were to characterize cognitive funct...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10816
更新日期:2002-09-15 00:00:00
abstract:BACKGROUND:This study was performed to clarify the clinicopathologic features of hepatocellular carcinoma (HCC) patients surviving >10 years after hepatic resection. METHODS:Between January 1971 and April 1987, 142 patients underwent hepatic resection. Thirty-nine patients who died of surgical morbidity (surgical mort...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract::To assess the value in Ewing's sarcoma of a new multiagent therapy (vincristine, cyclophosphamide, Adriamycin, (doxorubicin) procarbazine), 30 children with a localized tumor (eight distal, nine proximal, 13 central lesions) treated at the Institut Gustave-Roussy between 1973 and 1976 (E3), were pair-matched by site o...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19830801)52:3<415::aid-cncr28205
更新日期:1983-08-01 00:00:00
abstract::The incidence of breast cancer rose about 1% per year between 1940 and 1980 according to data in the Connecticut Tumor Registry. A sharp increase of 32% was reported between 1980 and 1987 in the Surveillance, Epidemiology and End Results Program of the National Cancer Institute. Data from this program shows that the i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820741304
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:The authors evaluated the two indicators of metastatic proclivity (namely, virulence [V; the rate of appearance of distant metastases] and metastagenicity [M; the ultimate likelihood of developing distant metastases]) of breast carcinoma in elderly women. The authors then compared these characteristics with ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20206
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in situ carcinoma provides an op...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990701)86:1<31::aid-cncr
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Image-directed biopsies may be collected as histologic or cytologic specimens. METHODS:In 34 patients, the results of aspiration cytologic examination were compared prospectively with core tissue biopsy findings obtained and diagnosed independently using the same image-guided procedure. RESULTS:Cytologic e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921015)70:8<2187::aid-cncr2820
更新日期:1992-10-15 00:00:00
abstract::Malignant salivary gland neoplasms in children are rare. Such tumors usually occur in the parotid gland of older children. Sixteen cases of major salivary gland malignancy are reviewed, 14 occurring in the parotid gland and two in the submandibular gland. Adenoid cystic carcinoma was the most common malignancy encount...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850415)55:8<1730::aid-cncr2820
更新日期:1985-04-15 00:00:00
abstract:BACKGROUND:To study the correlation of environmental exposure to potentially mutagenic agents and the clinicopathologic picture in acute myeloid leukemia (AML), clinical features, morphologic characteristics, immunophenotype, and cytogenetics were studied in 59 patients with newly diagnosed AML. METHODS:Based on inter...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920701)70:1<77::aid-cncr282070
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:The human papillomavirus (HPV) E2 protein is a transcriptional repressor of the oncogenes E6/E7 and loss of E2 function is considered a key step in carcinogenesis. Integration of HPV into the host genome may disrupt the E2 gene. Furthermore, methylation of CpG dinucleotides in E2-binding sites (E2BSs) in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29315
更新日期:2015-06-15 00:00:00
abstract:BACKGROUND:Trimetrexate is an antifol that differs from methotrexate in ways that may be clinically important. Because methotrexate has activity in advanced bladder cancer, this trial was initiated. METHODS:Ambulatory patients with advanced urothelial carcinoma were treated with the nonclassic antifol trimetrexate at ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19940201)73:3<688::aid-cncr28207
更新日期:1994-02-01 00:00:00
abstract::Two cases of Wilms' tumor in adolescent males are presented. The clinical and radiographic findings were unusual and both presented atypical gross and microscopic features that could be correlated with the radiographic findings. Histologic examination of both tumors showed evidence of tubular and glomerular maturation...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1532::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) was measured in extracts of cell suspensions from tumors of the colon, stomach, breast, lung and kidney. Cell suspensions were also obtained from normal tissue surrounding the primary tumors. The number of neoplastic cells in each cell suspension was determined by cytologic criteria. Hig...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197708)40:2<808::aid-cncr2820400
更新日期:1977-08-01 00:00:00
abstract:BACKGROUND:The lack of comparable metrics to evaluate prevention and early detection patient navigation programs impeded the ability to identify best practices. METHODS:The Prevention and Early Detection Workgroup of the Patient Navigation Leadership Summit was charged with making recommendations for common clinical m...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26267
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Interferon-alpha (IFN-alpha) has shown significant activity in the treatment of BCR-ABL-negative myeloproliferative disorders (MPDs), particularly essential thrombocythemia (ET) and polycythemia vera (PV). PEG-IFN-alpha-2b is a pegylated IFN-alpha-2b with a significant advantage over nonpegylated form in tha...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23018
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:The authors conducted this study to update their experience with patients who have ovarian serous borderline tumors with noninvasive peritoneal implants, with the objectives of gaining additional insight into the biologic behavior of these tumors and understanding better the effects of postoperative treatmen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19981115)83:10<2157::aid-c
更新日期:1998-11-15 00:00:00
abstract:BACKGROUND:The authors attempted to obtain shared proteins among lung carcinoma cells by column chromatographies. A glycoprotein with approximately 500 kDa isolated from QG56 cells showed an identical amino acid sequence to 90K/Mac-2 binding protein (M2BP). This protein has been reported to be highly expressed and to m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10899
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Although pediatric cancer mortality and survival have improved in the United States over the past 40 years, differences exist by age, race/ethnicity, cancer site, and economic status. To assess progress, this study examined recent mortality and survival data for individuals younger than 20 years. METHODS:Ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33080
更新日期:2020-10-01 00:00:00