Abstract:
BACKGROUND:The prognostic value of flow cytometric analysis of DNA content is contradictory in renal cell carcinoma (RCC). METHODS:Flow cytometric analysis was performed on 72 patients with RCC, and the relationship between the DNA content and pathologic or clinical features was investigated. RESULTS:Aneuploidy was observed in 36 (50%) of these patients. Two tissue samples from primary tumors of 12 patients were analyzed, and heterogeneity was found in 7 (58%) of these patients. The incidence of aneuploidy was significantly higher in high-grade than in low-grade tumors (P = 0.0328). All five tumors with a maximum diameter of 2.5 cm or smaller (T1N0M0) were diploid, and a trend for more aneuploid tumors among high-stage diseases was observed. The survival rate of patients with diploid tumors was not significantly different from that of those with aneuploid tumors in the low- or high-stage group. CONCLUSIONS:DNA ploidy assessed with one sample is not a prognostic factor, and heterogeneity between different samples of a given tumor indicates that one sample is not enough for DNA flow cytometry in RCC.
journal_name
Cancerjournal_title
Cancerauthors
Nakano E,Kondoh M,Okatani K,Seguchi T,Sugao Hdoi
10.1002/1097-0142(19930815)72:4<1319::aid-cncr2820subject
Has Abstractpub_date
1993-08-15 00:00:00pages
1319-23issue
4eissn
0008-543Xissn
1097-0142journal_volume
72pub_type
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