Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation.

abstract：:The frequency and significance of hyperprolactinemia was studied in 21 consecutive, untreated male patients with bronchogenic carcinoma. Seven patients (33%) were found to have elevated serum prolactin (hPRL) levels. No correlation was demonstrated between increased hPRL levels, tissue histology, or tumor burden. L-do...

journal_title：Cancer

authors： Davis S,Proper S,May PB,Ertel NH

更新日期：1979-08-01 00:00:00

abstract：:Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...

journal_title：Cancer

authors： Herbst WM,Kummer W,Hofmann W,Otto H,Heym C

更新日期：1987-11-15 00:00:00

abstract：:The exact nature of the association between hormones and the development of breast cancer remains uncertain. Studies of endogenous hormone levels and breast cancer suggest a possible role of estrogens and androgens in the cause of breast cancer. Numerous studies have been conducted to assess the risk of breast cancer ...

journal_title：Cancer

authors： Helzlsouer KJ,Couzi R

更新日期：1995-11-15 00:00:00

abstract：:Patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) were treated with a combination of alpha-interferon and gamma-interferon. Recombinant alpha-2a-interferon (Roferon-A, Hoffmann-LaRoche, Inc., Nutley, NJ) and recombinant gamma-interferon (Genentech, Inc., South San Francisco, CA) were ad...

journal_title：Cancer

authors： Talpaz M,Kurzrock R,Kantarjian H,Rothberg J,Saks S,Evans L,Gutterman JU

更新日期：1991-11-15 00:00:00

abstract：BACKGROUND:A retrospective clinicopathologic study was performed to identify the influence of diagnostic and therapeutic procedures on the outcomes of patients with the follicular variant of papillary thyroid carcinoma (FVPTC). METHODS:The results of 37 patients with FVPTC were compared with those of 37 randomly selec...

journal_title：Cancer

authors： Tielens ET,Sherman SI,Hruban RH,Ladenson PW

更新日期：1994-01-15 00:00:00

abstract：BACKGROUND:Although flow cytometry (FCM) has become a widely used technique for the measurement of DNA content in solid tumors, the correlation of ploidy analysis by FCM with cytogenetic analysis (CGA) is not well described. The sensitivities of G-banded CGA and FCM were compared to determine the accuracy of the DNA in...

journal_title：Cancer

authors： Dressler LG,Duncan MH,Varsa EE,McConnell TS

更新日期：1993-09-15 00:00:00

abstract：BACKGROUND:The prognostic impact of DNA mismatch repair (MMR) status remains controversial in patients with stage III colon cancer who are treated with adjuvant chemotherapy (AC). The aim of this study was to evaluate the survival outcome of AC in deficient mismatch repair (dMMR)/microsatellite instable (MSI) stage III...

journal_title：Cancer

authors： Shaib WL,Zakka KM,Jiang R,Yan M,Alese OB,Akce M,Wu C,Behera M,El-Rayes BF

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Amplification of erb-B2 and myc shows prognostic value in patients with operable breast cancer. Amplification is usually detected in tumor samples remaining after pathologic work-up, preventing the examination of small tumors. METHODS:Tumor imprints that contained low numbers of contaminating normal cells w...

journal_title：Cancer

authors： Lönn U,Lönn S,Nilsson B,Stenkvist B

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:The primary objective of this study was to clarify the significance of p21WAF1/CIP1(p21) gene expression in the tumorgenicity of hepatitis B virus (HBV) and hepatitis C virus (HCV) infected human hepatocelluar carcinoma (HCC). METHODS:The authors performed Northern blot hybridization to compare the p21 mess...

journal_title：Cancer

authors： Kobayashi S,Matsushita K,Saigo K,Urashima T,Asano T,Hayashi H,Ochiai T

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:This study was designed to assess the toxicity of pelvic radiation therapy, 5-fluorouracil (5-FU) administered by protracted venous infusion, and leucovorin. METHODS:Pelvic radiation therapy consisted of 50.4-54 gray (Gy) administered in 28-30 fractions. Systemic treatment consisted of leucovorin (10 mg dai...

journal_title：Cancer

authors： Martenson JA,Shanahan TG,O'Connell MJ,Cobau CD,Schroeder G,Burch PA,Levitt R,Rowland KM Jr

更新日期：1999-08-15 00:00:00

abstract：BACKGROUND:The aim was to determine the long-term outcome for patients with FIGO stage IV epithelial ovarian carcinoma (EOC) treated with intraperitoneal (IP) chemotherapy after second-look assessment. METHODS:By using data from a retrospective cohort of 433 patients who received IP therapy after second-look assessmen...

journal_title：Cancer

authors： Zivanovic O,Barakat RR,Sabbatini PJ,Brown CL,Konner JA,Aghajanian CA,Abu-Rustum NR,Levine DA

更新日期：2008-06-15 00:00:00

abstract：:If health professionals wish to help increase the number of older adults who get screened regularly to detect cancer at an early stage, they must first understand the barriers to screening that older people experience. This paper discusses the barriers older women face regarding mammography screening. Data from Americ...

journal_title：Cancer

authors： Rubenstein L

更新日期：1994-10-01 00:00:00

abstract：:The potential role of paraneoplastic Cushing's syndrome (CS) was assessed on the clinical course of patients with small cell lung cancer. A retrospective comparison was done of complications and survival rates according to the presence or absence of CS in patients with small cell lung cancer who died within 90 days of...

journal_title：Cancer

authors： Dimopoulos MA,Fernandez JF,Samaan NA,Holoye PY,Vassilopoulou-Sellin R

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Pleomorphic liposarcoma (PLS) is a rare high-grade sarcoma that has lipoblastic differentiation. In this study, the authors evaluated PLS natural history, patient outcomes, and commonly deregulated protein biomarkers. METHODS:Medical records from patients (n = 155) who had PLS from 1993 to 2010 were reviewe...

journal_title：Cancer

authors： Ghadimi MP,Liu P,Peng T,Bolshakov S,Young ED,Torres KE,Colombo C,Hoffman A,Broccoli D,Hornick JL,Lazar AJ,Pisters P,Pollock RE,Lev D

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The purpose of the current study was to describe a population of young patients with breast carcinoma, their characteristics at the time of diagnosis, and the association of these characteristics with disease recurrence and survival. METHODS:Four hundred fifty-two women age < or = 35 years with breast carci...

journal_title：Cancer

authors： Gonzalez-Angulo AM,Broglio K,Kau SW,Eralp Y,Erlichman J,Valero V,Theriault R,Booser D,Buzdar AU,Hortobagyi GN,Arun B

更新日期：2005-06-15 00:00:00

abstract：BACKGROUND:Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone-refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. METHODS:Twenty-three patients with ...

journal_title：Cancer

authors： Roth BJ,Yeap BY,Wilding G,Kasimis B,McLeod D,Loehrer PJ

更新日期：1993-10-15 00:00:00

abstract：:The case of a patient who underwent a left lower lobe lobectomy for adenocarcinoma of the lung and developed a metachronous squamous cell carcinoma of the right lung eight years later, is presented. The unusual nature of the case is emphasized utilizing a review of the literature. The criteria for diagnosing metachron...

journal_title：Cancer

authors： Coffman B,Crum E,Forman WB

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Two-thirds of cancer cases are associated with two lifestyle practices: 35% with the typical American diet, and 30% with tobacco use. In contrast to the field of tobacco control, research and resources dedicated to the field of nutrition have been limited, in part because dietary change has been considered c...

journal_title：Cancer

authors： Bal DG,Foerster SB

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:The authors analyzed the secretion of extracellular matrix-degrading proteinases, including urinary-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2, gelatinase A), and MMP-9 (gelatinase B), by short term primary cultures of epithelial ovarian carcinoma cells derived from primary ovarian ...

journal_title：Cancer

authors： Fishman DA,Bafetti LM,Banionis S,Kearns AS,Chilukuri K,Stack MS

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:The difficulties adolescents and young adults (AYAs) encounter during a cancer experience may result in a reduction in or absence of empowerment. The aims of the current study were to assess levels of empowerment and associated (demographic, clinical, or psychological) factors and examine the association bet...

journal_title：Cancer

authors： Kaal SEJ,Husson O,van Duivenboden S,Jansen R,Manten-Horst E,Servaes P,Prins JB,van den Berg SW,van der Graaf WTA

更新日期：2017-10-15 00:00:00

abstract：:Four courses of ifosfamide with mesna given by intravenous infusions were combined with bolus doxorubicin in a phase II trial to treat patients with breast cancer. Ifosfamide can deplete intracellular glutathione levels and because doxorubicin resistance may be associated with elevated levels of intracellular glutathi...

journal_title：Cancer

authors： Millward MJ,Harris AL,Cantwell BM

更新日期：1990-06-01 00:00:00

abstract：:In 1963 an electron beam became available, making irradiation of the chest wall technically easy. In addition to peripheral lymphatic irradiation in patients with positive axillary nodes and/or the tumor in the inner quadrants or centrally located, patients with tumor larger than 5 cm or with grave signs and/or a sign...

journal_title：Cancer

authors： Tapley ND,Spanos WJ Jr,Fletcher GH,Montague ED,Schell S,Oswald MJ

更新日期：1982-03-15 00:00:00

abstract：BACKGROUND:Shared decision-making (SDM) occurs when a patient partners with their oncologist to integrate personal preferences and values into treatment decisions. A key component of SDM is the elicitation of patient preferences and values, yet little is known about how and when these are elicited, communicated, priori...

journal_title：Cancer

authors： Williams CP,Miller-Sonet E,Nipp RD,Kamal AH,Love S,Rocque GB

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Early stage lung cancer has a variable prognosis, and there are currently no markers that predict which patients will recur. This study examined the relation between tumor-regulatory T (Treg) cells and total tumor-infiltrating T-cell lymphocytes (TIL) to determine whether they correlated with recurrence. ME...

journal_title：Cancer

authors： Petersen RP,Campa MJ,Sperlazza J,Conlon D,Joshi MB,Harpole DH Jr,Patz EF Jr

更新日期：2006-12-15 00:00:00

abstract：:The role of palliative radiation treatment of prostate cancer is well recognized. Appreciation of the value of definitive radiation therapy in management of locally advanced prostate cancer is increasing. Optimal management requires careful patient selection with multidiscipline evaluation to provide accurate grading ...

journal_title：Cancer

authors： Taylor WJ

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Meeting quality of care standards in oncology is recognized as important by physicians, professional organizations, and payers. Data from a population-based cohort of patients with prostate cancer were used to examine whether receipt of care was consistent with published consensus metrics and whether receivi...

journal_title：Cancer

authors： Holmes JA,Bensen JT,Mohler JL,Song L,Mishel MH,Chen RC

更新日期：2017-01-01 00:00:00

abstract：:One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...

journal_title：Cancer

authors： Ng EH,Pollock RE,Romsdahl MM

更新日期：1992-03-15 00:00:00

abstract：BACKGROUND:In patients with locoregional carcinoma of the esophagus or esophagogastric junction who underwent preoperative chemoradiation, it is unclear whether survival was better predicted by pretherapy clinical stage or by posttherapy pathologic stage. METHODS:The authors studied 235 consecutive patients with preth...

journal_title：Cancer

authors： Chirieac LR,Swisher SG,Ajani JA,Komaki RR,Correa AM,Morris JS,Roth JA,Rashid A,Hamilton SR,Wu TT

更新日期：2005-04-01 00:00:00

abstract：:Two patients developed extremely bizarre (pseudomalignant) granulation-tissue reactions in the larynx and facial sinuses, following radiation therapy for carcinoma. Containing pleomorphic spindle cells and numerous (sometimes atypical) mitotic figures, both tumefactive lesions simulated high grade malignancies. While ...

journal_title：Cancer

authors： Weidner N,Askin FB,Berthrong M,Hopkins MB,Kute TE,McGuirt FW

更新日期：1987-04-15 00:00:00

abstract：BACKGROUND:Response rates in chronic myeloid leukemia (CML) are now reported based on the cumulative incidence of a single-time best response. The study aim was to examine the significance of different response criteria for CML on imatinib therapy. METHODS:In all, 276 patients with chronic phase CML on imatinib therap...

journal_title：Cancer

authors： Kantarjian H,O'Brien S,Shan J,Huang X,Garcia-Manero G,Faderl S,Ravandi-Kashani F,Verstovsek S,Beth Rios M,Cortes J

更新日期：2008-02-15 00:00:00