Phase I study of 5-fluorouracil administered by protracted venous infusion, leucovorin, and pelvic radiation therapy.

abstract：:If radical surgery is the only rational policy for most cases of rectal cancer, the problem of local treatment in poor surgical risk patients should be discussed in selected cases. Only limited, fairly-well-differentiated tumors, still confined to the rectal wall may have a sufficiently low probability of lymphatic sp...

journal_title：Cancer

authors： Papillon J

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Patients with basal cell carcinoma (BCC) demonstrate marked variation in clinical phenotype, suggesting the presence of distinct subgroups. Patients with truncal lesions comprise an interesting subgroup, because, although the pathogenesis of these tumors is unclear, there is evidence to suggest that their de...

journal_title：Cancer

authors： Ramachandran S,Fryer AA,Smith A,Lear J,Bowers B,Jones PW,Strange RC

更新日期：2001-07-15 00:00:00

abstract：BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...

journal_title：Cancer

authors： Turner BC,Gumbs AA,Carbone CJ,Carter D,Glazer PM,Haffty BG

更新日期：2000-03-01 00:00:00

abstract：:A Phase I/II accelerated fractionation study for high-grade cerebral astrocytomas began in October 1987. Forty-two patients, 25 men and 17 women, were entered in the study. Median age was 58.5 years of age (range, 32 to 78 years). Performance status was 0, 1, 2, and 3 on Eastern Cooperative Oncology Group (ECOG) scale...

journal_title：Cancer

authors： Shenouda G,Souhami L,Freeman CR,Hazel J,Lehnert S,Joseph L

更新日期：1991-05-01 00:00:00

abstract：:Hepatoblastoma differs from the adult type of hepatoma in clinical and pathologic features. The ratio of fucosylation of serum alpha-fetoprotein (AFP) was determined in seven patients with hepatoblastoma and in 21 infants and children with otherwise elevated serum AFP, using the improved technique of lentil agglutinin...

journal_title：Cancer

authors： Tsuchida Y,Honna T,Fukui M,Sakaguchi H,Ishiguro T

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer. However, the mechanism of peritoneal metastasis remains unclear. We therefore investigated the interaction between gastric cancer cells and peritoneal fibroblasts, in vivo and in vitro. METHODS:A human scirrhous gastric...

journal_title：Cancer

authors： Yashiro M,Chung YS,Nishimura S,Inoue T,Sowa M

更新日期：1996-04-15 00:00:00

abstract：:Esophageal dilation by means of guided Neoplex (Medoc) tubes in 38 patients with malignant obstruction of the esophagus was analyzed. Peroral dilation proved to be a simple, well-tolerated primary procedure in the management of malignant strictures. Most patients have a temporary improvement of dysphagic symptoms, but...

journal_title：Cancer

authors： Aste H,Munizzi F,Martines H,Pugliese V

更新日期：1985-12-01 00:00:00

abstract：:We report the clinical and pathologic features of two cases of adenosarcoma. Our first case occurred in the ovary of a 51-year-old woman with extensive pelvic involvement. She was treated vigorously with radiation and chemotherapy and at the present time almost 9 years later the patient is free of disease. This repres...

journal_title：Cancer

authors： Valdez VA,Planas AT,Lopez VF,Goldberg M,Herrera NE

更新日期：1979-04-01 00:00:00

abstract：:Human prostate specimens from 25 patients provided 15 normal, four benign prostatic hypertrophy (BPH), and seven adenocarcinoma samples which were studied using a polyclonal antibody against prostatic specific antigen (PSA) and protein A-gold complex. Our study showed the presence of gold particles in cytoplasmic vesi...

journal_title：Cancer

authors： Sinha AA,Wilson MJ,Gleason DF

更新日期：1987-09-15 00:00:00

abstract：BACKGROUND:Stomatitis has been found to be a major dose-limiting toxicity from bolus 5-fluorouracil-based (5-FU) chemotherapy regimens, despite the use of oral cryotherapy. Pursuant to preliminary data which suggested that a chamomile mouthwash might ameliorate this toxicity, a prospective trial was developed to test c...

journal_title：Cancer

authors： Fidler P,Loprinzi CL,O'Fallon JR,Leitch JM,Lee JK,Hayes DL,Novotny P,Clemens-Schutjer D,Bartel J,Michalak JC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:DNA ploidy and S-phase fraction measured by DNA flow cytometry were shown to correlate with several clinicopathologic characteristics in several types of tumors. METHODS:DNA flow cytometry was performed on 329 samples (164 normal mucosa, 165 tumors) obtained from 165 patients (112 men) with stomach cancer, ...

journal_title：Cancer

authors： Lee KH,Lee JS,Suh C,Ahn MJ,Kim SW,Doh BS,Min YI,Kim BS,Park KC,Lee IC

更新日期：1993-09-15 00:00:00

abstract：:A new human lymphoblastic lymphoma cell line was established (designated HT-1) from the pleural fluid lymphoma cells of a patient with lymphoblastic lymphoma of T-cell type. The HT-1 cells expressed CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD57, and terminal deoxynucleotidyl transferase (TdT) but lacked B-cell-associated an...

journal_title：Cancer

authors： Abe M,Tasaki K,Nozawa Y,Tominaga K,Fukuhara S,Ohsato T,Wakasa H

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Cytologic distinction between follicle center lymphoma (FCL) and mantle cell lymphoma (MCL) is difficult with cytomorphology alone and requires immunophenotyping. The current study describes the distinction between follicle center and mantle cell lymphoma made with fine-needle aspiration (FNA) material. MET...

journal_title：Cancer

authors： Rassidakis GZ,Tani E,Svedmyr E,Porwit A,Skoog L

更新日期：1999-08-25 00:00:00

abstract：:Management of testis cancer in children differs from that in adults due to the histological types and varying tolerances to chemotherapy agents. Embryonal adrenocarcinoma (endodermal sinus tumor, Teilum's tumor) is a tumor of infancy and young children and less aggressive than other testis cancers. Most cases require ...

journal_title：Cancer

authors： Exelby PR

更新日期：1980-04-01 00:00:00

abstract：:Selective adsorption of several common "monospecific" HLA typing sera with HLA typed platelets, purified B lymphocytes, cultured lymphoid cells, or lymphocytes from patients with active chronic lymphocytic leukemia demonstrated that many of these sera contain antibodies to non-HLA antigens. Antibodies were detected to...

journal_title：Cancer

authors： Pollack MS,DuBois D

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:The clinical features and natural history of adrenocortical carcinoma are highly dependent on the type of center reporting their experience. Observations from oncology services suggest a high incidence of nonfunctioning tumors, whereas reports from endocrine clinics emphasize excessive corticoid and androgen...

journal_title：Cancer

authors： Wajchenberg BL,Albergaria Pereira MA,Medonca BB,Latronico AC,Campos Carneiro P,Alves VA,Zerbini MC,Liberman B,Carlos Gomes G,Kirschner MA

更新日期：2000-02-15 00:00:00

abstract：:Lymphoblasts from "null cell" acute lymphocytic leukemia (ALL) were analyzed for the pattern of proliferation displayed in a mixed lymphocyte reaction (MLR), the presence of a B cell surface antigen, and for the presence of intracytoplasmic immunoglobulin (ICIg). "Null cell" ALL was defined by cytologic and cytochemic...

journal_title：Cancer

authors： Davey FR,Dock NL,Wolos JA,Terzian JA,Gottlieb AJ

更新日期：1979-11-01 00:00:00

abstract：:Utah cancer mortality for the years 1950-1969 and morbidity for the years 1966-1970 are reported. Utah had 18% fewer cases of cancer than expected based on the Third National Cancer Survey, and 24% fewer cancer deaths than expected based on national mortality data. Cancer sites associated with cigarette smoking and al...

journal_title：Cancer

authors： Lyon JL,Gardner JW,Klauber MR,Smart CR

更新日期：1977-06-01 00:00:00

abstract：:Hereditary cancer represents approximately 5-10% of the total cancer burden and may account for 60,000 to 120,000 new cancer occurrences this year in the United States. New developments in molecular genetics and the cloning of cancer-prone genes have intensely fueled interest in dealing with hereditary forms of cancer...

journal_title：Cancer

authors： Lynch HT,Watson P,Shaw TG,Lynch JF,Harty AE,Franklin BA,Kapler CR,Tinley ST,Liu B

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor 3 (VEGFR-3). By contrast, lymphatic spread is an important prognostic factor in patients with nonsmall cell lung carcinoma (NSCLC). The objective of the current study was to determine whethe...

journal_title：Cancer

authors： Arinaga M,Noguchi T,Takeno S,Chujo M,Miura T,Uchida Y

更新日期：2003-01-15 00:00:00

abstract：BACKGROUND:The human papillomavirus (HPV) E2 protein is a transcriptional repressor of the oncogenes E6/E7 and loss of E2 function is considered a key step in carcinogenesis. Integration of HPV into the host genome may disrupt the E2 gene. Furthermore, methylation of CpG dinucleotides in E2-binding sites (E2BSs) in the...

journal_title：Cancer

authors： Reuschenbach M,Huebbers CU,Prigge ES,Bermejo JL,Kalteis MS,Preuss SF,Seuthe IM,Kolligs J,Speel EJ,Olthof N,Kremer B,Wagner S,Klussmann JP,Vinokurova S,von Knebel Doeberitz M

更新日期：2015-06-15 00:00:00

abstract：:A growing body of research shows that a majority of patients with cancer report having religious and spiritual (R/S) beliefs, engaging in R/S behaviors, or deriving comfort from R/S experiences. These studies have been reviewed but not subjected to rigorous critical analysis. A meta-analytic approach is needed to prov...

journal_title：Cancer

authors： Salsman JM,Fitchett G,Merluzzi TV,Sherman AC,Park CL

更新日期：2015-11-01 00:00:00

abstract：:The ability of infantile hypercalcemic tumors (three rhabdoid renal tumors, one cellular mesoblastic nephroma, and one hepatoblastoma) to produce parathyroid hormone (PTH) was tested using RNA-DNA hybridization. Results were compared with those obtained in one lung epidermoid carcinoma and one parathyroid adenoma from...

journal_title：Cancer

authors： Rousseau-Merck MF,de Keyzer Y,Bourdeau A,Cournot G,Mercier F,Nezelof C

更新日期：1988-07-15 00:00:00

abstract：BACKGROUND:Although lenalidomide maintenance therapy has demonstrated improved outcomes after autologous hematopoietic stem cell transplantation (auto-HCT) for patients with multiple myeloma (MM), the impact of the duration of this therapy is not clearly known. METHODS:This study retrospectively analyzed all MM patien...

journal_title：Cancer

authors： Mian I,Milton DR,Shah N,Nieto Y,Popat UR,Kebriaei P,Parmar S,Oran B,Shah JJ,Manasanch EE,Orlowski RZ,Shpall EJ,Champlin RE,Qazilbash MH,Bashir Q

更新日期：2016-12-15 00:00:00

abstract：:Associations were sought between specific histocompatibility antigens (HLA) of the human major histocompatibility complex and the incidence of head and neck squamous cell carcinoma (SqCC). Seventy sequential patients with SqCC and 217 control subjects from the same geographic region were typed for HLA-A, HLA-B, and HL...

journal_title：Cancer

authors： Houck JR,Romano PJ,Bartholomew M,Smith PJ,Kloszewski F,Vesell ES

更新日期：1992-05-01 00:00:00

abstract：:111Indium-Bleomycin (111In-Blm), a new radiopharmaceutical, was administered intravenously to 37 patients with benign and malignant breast lesions. Early and delayed images of both the breasts and axillae were made, and results were correlated with physical examination, histopathology of the excised lesion, mammograph...

journal_title：Cancer

authors： Silverstein MJ,Verma RC,Greenfield L,Morton DL

更新日期：1976-01-01 00:00:00

abstract：:Four cases of non-Hodgkin's lymphoma (NHL) limited to the larynx are described. All were diffuse, high-grade, B-cell lymphomas of large lymphoid cell type (three centroblastic and one immunoblastic). Immunocytochemistry was performed on three cases; two showed monoclonal cytoplasmic immunoglobulin and one showed monoc...

journal_title：Cancer

authors： Morgan K,MacLennan KA,Narula A,Bradley PJ,Morgan DA

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the patterns of recurrence, various prognostic factors, and the role of radioiodine in the treatment of patients with follicular thyroid carcinoma (FTC). METHODS:The clinical outcomes of 215 patients with FTC who were treated at a single institution were analyz...

journal_title：Cancer

authors： Chow SM,Law SC,Mendenhall WM,Au SK,Yau S,Yuen KT,Law CC,Lau WH

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Retrospective studies suggest that dose intensity is an important determinant of outcome in the treatment of patients with a variety of malignant diseases such as breast cancer, ovarian cancer, and lymphoma. Unfortunately, these results have not been clearly substantiated in prospective randomized trials. On...

journal_title：Cancer

authors： Long GD,Negrin RS,Hoyle CF,Kusnierz-Glaz CR,Schriber JR,Blume KG,Chao NJ

更新日期：1995-09-01 00:00:00

abstract：:Malignant melanoma can potentially involve any organ system in the body once it metastasizes beyond the regional lymph nodes. A survey of the radiographic and associated clinical manifestations of metastatic melanoma is presented. The findings from 74 autopsies of patients who died of metastatic melanoma are included....

journal_title：Cancer

authors： Meyer JE

更新日期：1978-07-01 00:00:00