Abstract:
:A new human lymphoblastic lymphoma cell line was established (designated HT-1) from the pleural fluid lymphoma cells of a patient with lymphoblastic lymphoma of T-cell type. The HT-1 cells expressed CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD57, and terminal deoxynucleotidyl transferase (TdT) but lacked B-cell-associated antigens and myeloid-associated antigens. In addition, HT-1 cells had rearranged T-cell receptor (TCR) beta-chain gene and gamma-chain gene but retained germlines of immunoglobulin (Ig) heavy chain gene. These findings indicate that HT-1 cell line represents a common thymocyte in the T-cell lineage. Cytogenetic studies revealed that HT-1 cells carry an inversion (inv) of the long arm of chromosome 14. This cell line is the second T-cell line carrying inv(14) chromosome and may be useful for the molecular investigation of the cytogenetic break points of inv(14).
journal_name
Cancerjournal_title
Cancerauthors
Abe M,Tasaki K,Nozawa Y,Tominaga K,Fukuhara S,Ohsato T,Wakasa Hdoi
10.1002/cncr.2820690527subject
Has Abstractpub_date
1992-03-01 00:00:00pages
1235-40issue
5eissn
0008-543Xissn
1097-0142journal_volume
69pub_type
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