Management of asparaginase induced hemorrhagic pancreatitis complicated by pseudocyst.

Abstract:

:Asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. Severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18-year-old patient with acute lymphoblastic leukemia following treatment with asparaginase. There was a dramatic response to high flow peritoneal lavage with rapid recovery within 24 hours from a moribund state. The subsequent development of a pseudocyst, with progressive increase in size and development of obstructive symptoms, required surgical decompression. Transgastric cystogastrostomy was successfully carried out.

journal_name

Cancer

journal_title

Cancer

authors

Greenstein R,Nogeire C,Ohnuma T,Greenstein A

doi

10.1002/1097-0142(197902)43:2<718::aid-cncr2820430

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

718-22

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

43

pub_type

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