Abstract:
:The role of hyperthermic isolation perfusion in the treatment of advanced melanoma of the limbs is clearly important. However, attention has in the past been focussed mainly on surgical aspects of the procedure. Whereas, equivalent interest in chemotherapy considerations has been lacking. A group of 15 patients have been treated by hyperthermic isolated perfusion for advanced melanoma of the limbs. The chemotherapeutic agent used was cisplatin. The follow-up period was 6 to 60 months. None of these patients had any sign or symptoms of toxicity from the drug. Twelve of these 15 patients are free of disease currently. There was one case of mortality due to unrelated cause and two cases of mortality due to disseminated disease which developed 6 months and 30 months, respectively, posttreatment. Since not uncommon toxic side effects from other drugs used for this procedure is significant, these results suggest that cisplatin may be used as an alternative chemotherapeutic agent in isolation perfusion for advanced melanoma of the extremities.
journal_name
Cancerjournal_title
Cancerauthors
Klein ES,Ben-Ari GYdoi
10.1002/1097-0142(19870315)59:6<1068::aid-cncr2820subject
Has Abstractpub_date
1987-03-15 00:00:00pages
1068-71issue
6eissn
0008-543Xissn
1097-0142journal_volume
59pub_type
杂志文章相关文献
CANCER文献大全abstract::Breast cancer tissue from 12 male patients was evaluated for the presence of estrogen receptors (ER), and at least 10 of 12 were found to be high in ER (ER+). A combination of previously published cases and our own experience indicates that 80% of patients (37/47) have ER+ tumors. This incidence of ER positivity in me...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810101)47:1<134::aid-cncr28204
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:The development of novel therapeutic approaches for cancer therapy is important, especially for tumors that have poor response or develop resistance to standard chemotherapy and radiation. We discovered that noninvasive radiofrequency (RF) fields can affect cancer cells but not normal cells, inhibit progress...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28895
更新日期:2014-11-01 00:00:00
abstract::Despite proven benefits of neoadjuvant chemotherapy in patients with locally advanced, invasive breast cancer, no regimen is recommended as the treatment of choice. Neoadjuvant chemotherapy regimens encompass single-agent and combination therapy and sequential treatment. For this report, the author reviewed the litera...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23083
更新日期:2007-12-01 00:00:00
abstract::A case is presented of a man with ulcerating skin nodules who was diagnosed by histologic and immunohistologic analysis of skin biopsy specimens as having lymphomatoid granulomatosis (LYG). Phenotypic studies showed the majority of the infiltrating cells to be activated CD4+ T-lymphocytes. The disease followed a rapid...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890215)63:4<652::aid-cncr28206
更新日期:1989-02-15 00:00:00
abstract:BACKGROUND:This survey documents the strategies used by pain control physicians in the selection of opioid drugs and routes of administration in the management of inpatients referred to a cancer pain service. METHODS:The following approaches were prospectively evaluated during the treatment of 100 consecutive inpatien...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951001)76:7<1283::aid-cncr2820
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:The prognostic significance of molecular phenotype in breast cancer is well established in the literature. Recent studies have demonstrated that subgross lesion distribution (unifocal, multifocal, and diffuse) and disease extent also carry prognostic significance in this disease. However, the correlation of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27877
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Ideally, screening detects cancer at a more curable stage and, as a result, decreases the rate of subsequent diagnosis at a late stage. Although it is suggested that some cancer screening tests have led to substantial increases in early-stage incidence with only marginal reductions in late-stage incidence (e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28794
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:The first step of colorectal carcinoma spread depends on the ability of the tumor cells to degrade and invade the extracellular matrix (ECM). The objectives of the current study were to evaluate the serum pattern of laminin, C-terminal peptide of Type I (PIP), and N-terminal peptide of Type III (PIIIP) proco...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19970401)79:7<1299::aid-cn
更新日期:1997-04-01 00:00:00
abstract::A 24-year-old woman was found to have a diffuse large cell lymphoma arising within thyroid tissue within a mature cystic teratoma of the ovary. To the authors' knowledge, this is the first reported case of malignant lymphoma arising within a teratoma of the ovary. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861201)58:11<2459::aid-cncr282
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Complete maturation (cytodifferentiation) of treated metastatic Wilms' tumor is an infrequent occurrence. In a large series of reports, Wilms' metastases have generally contained malignant blastemic elements admixed with lesser amounts of cytodifferentiated mesenchyme. The authors describe a patient in whom ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19970415)79:8<1629::aid-cn
更新日期:1997-04-15 00:00:00
abstract::Peanut agglutinin (PNA) receptors were studied in 37 cases of reactive follicular hyperplasia and 66 follicular lymphomas, using the unlabeled peroxidase-antiperoxidase (PAP) method on paraffin embedded material. Based on the binding sites of the lectin, positively stained cells were easily recognized as either cytopl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830501)51:9<1631::aid-cncr2820
更新日期:1983-05-01 00:00:00
abstract::Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune activation and dysregulation resulting in extreme and often life-threatening inflammation. HLH has been well recognized in pediatric populations, and most current diagnostic and therapeutic guidelines are based on pediatric HLH. Recently there has...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.30826
更新日期:2017-09-01 00:00:00
abstract::A Chinese patient with documented hepatocellular carcinoma (HCC) satisfied the criteria of Everson and Cole for spontaneous regression of malignant tumors. Subsequently he survived a tumor-free period of at least 13 years. During the period of regression, shrinkage of liver coincided with a rise of SGOT to a level com...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820715)50:2<332::aid-cncr28205
更新日期:1982-07-15 00:00:00
abstract::109 cases of breast cancer were treated by tumorectomy and radiotherapy or radiotherapy alone. Almost 30% with small tumors (T1, T2) were considered inoperable for medical reasons and 70% refused mastectomy. Over the past five years the number of patients refusing mastectomy has definitely increased. 59 cases of surgi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197810)42:4<2054::aid-cncr282042
更新日期:1978-10-01 00:00:00
abstract:BACKGROUND:Aggressive angiomyxoma is an uncommon mesenchymal tumor that preferentially involves the pelvic and perineal regions of females. Since its initial description in 1983, approximately 65 cases have been reported in the English literature. METHODS:The clinical and pathologic features of 29 cases of aggressive ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960701)78:1<79::AID-CNCR
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:The psychological adaptation to a cancer diagnosis is characterized by significant distress. Although distress levels in cancer patients have been reported to be the highest shortly after diagnosis and before treatment, few attempts have been made to study emotional adjustment during the diagnostic period of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10564
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:PD-L1 (programmed death ligand 1, B7-H1) is a cell surface glycoprotein that can impair T-cell function. PD-L1 is aberrantly expressed by multiple human malignancies and has been shown to carry a highly unfavorable prognosis in patients with kidney cancer. The role of PD-L1 was evaluated as a mechanism for l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22588
更新日期:2007-04-15 00:00:00
abstract:BACKGROUND:The reported frequency of gastrointestinal (GI) tract involvement in patients with mantle cell lymphoma (MCL) is 15-30%. However, this figure most likely is an underestimate because most patients with MCL involving the GI tract previously reported were examined endoscopically only if they had GI tract sympto...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11096
更新日期:2003-02-01 00:00:00
abstract::A system for staging the clinical status of patients with soft tissue sarcomas is presented, based on the clinical characteristics of the primary tumor (size, extension), the involvement of lymph nodes, the presence of metastases, and the grade of the tumor. This represents the TNM system with grade of tumor (G) added...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4<1562::aid-cncr282040
更新日期:1977-10-01 00:00:00
abstract::From November 1987 to April 1989, 1000 women 40 years or older underwent screening vaginal sonography at the University of Kentucky Medical Center (Lexington, KY). Patients included in this investigation were all asymptomatic and had no known pelvic abnormalities. Each ovary was measured in three planes and ovarian vo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900201)65:3<573::aid-cncr28206
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Although Kaposi sarcoma (KS) initially was described over a century ago, its biology remains enigmatic and conflicting. Whereas the classic type occurs mainly in older men of Mediterranean or Eastern European backgrounds and is not linked to impairment of the host immune response, iatrogenic and human immuno...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:A Phase II study with carboplatin, methotrexate, and vinblastine (CAMV) was conducted with patients who had advanced urothelial cancer to investigate the activity and toxicity of carboplatin when used in combination chemotherapy. METHODS:Thirty-six patients with advanced urothelial cancer were treated with ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19940401)73:7<1932::aid-cncr2820
更新日期:1994-04-01 00:00:00
abstract::A study of primary epithelial neoplasms of the appendix (with the exception of classical carcinoids), produced 24 adenocarcinomas and 42 benign lesions from the files of the Laboratory of Surgical Pathology of Columbia University. Invasive adenoarcinomas were often complicated by appendicitis and were then unexpectedl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197605)37:5<2493::aid-cncr282037
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:Brain metastases from soft tissue sarcoma (STS) are uncommon. To the authors' knowledge limited information is available regarding the influence of the initial STS site, the significance of parenchymal versus leptomeningeal metastases, and the role of surgical resection. METHODS:STS patients evaluated betwe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10554
更新日期:2002-05-15 00:00:00
abstract:BACKGROUND:Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The Univ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31112
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Natural killer (NK) cells are a group of effector cells that act nonspecifically against tumor cells. The correlation between intratumoral NK cell infiltration and clinicopathologic features remains unclear. METHODS:The authors selected 146 patients with gastric carcinoma who underwent gastrectomy at Kagosh...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::A previously unreported association of Brenner and adenomatoid tumor found in the tunica vaginalis testis is presented. Many ultrastructural features found in mesothelial cells such as intercellular spaces, deeply indented nuclei, tonofilaments and tight desmosomes, were also shared by cells present in both neoplastic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197902)43:2<539::aid-cncr2820430
更新日期:1979-02-01 00:00:00
abstract::From 1975 until 1984 37 children with newly diagnosed Hodgkin's disease were treated with six mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) courses with or without involved field radiotherapy (25 Gy) independent of the stage of their disease. Patients with small lymph node tumors (less than 4 cm) r...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870601)59:11<1870::aid-cncr282
更新日期:1987-06-01 00:00:00
abstract::An extrarenal malignant rhabdoid tumor (MRT) of the pelvis in a 14-year-old girl is described. The location of the tumor and age of the patient appear to be unique. The neoplasm is histologically and ultrastructurally identical to malignant rhabdoid tumor of the kidney seen in infants and very young children. The tumo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850501)55:9<1963::aid-cncr2820
更新日期:1985-05-01 00:00:00
abstract::In 79 cases of histologically verified anaplastic giant-cell carcinoma, symptoms, treatment, and prognosis were documented. Seventy-eight patients are dead, the mean survival time being 2.5 months. One patient is cured. It was concluded that surgery and/or radiotherapy alone are not sufficient. The results from an add...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197505)35:5<1293::aid-cncr282035
更新日期:1975-05-01 00:00:00