Abstract:
:One hundred four endocrine tumors found in the body and tail of the pancreas of a patient with the Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia (MEN-I) were investigated by immunohistochemistry for insulin, glucagon, somatostatin, pancreatic polypeptide (PP), and gastrin. The results for each tumor were scored into six grades according to the frequency of immunoreactive cells. Pancreatic polypeptide, glucagon, insulin, and somatostatin were demonstrated in 96, 80, 62, and 42 tumors, respectively. When only the higher scores of cell frequency (3-5) were considered, PP and glucagon (accounting for 71 and 49 tumors, respectively) differed markedly from insulin (two tumors) and somatostatin (0). The frequency of PP-immunoreactive cells was higher in tumors of large size whereas that of glucagon cells was higher in the smaller neoplasms. No significant associations of the tumoral hormonal expressions were found with the type of histologic structure (trabecular versus gyriform), the occurrence of stromal fibrosis, and the intrapancreatic location of the neoplasms, except for a higher number of somatostatin cells in fibrotic tumors. Gastrin-immunoreactive cells never were found in the tumors in spite of the concomitant hypergastrinemia. In conclusion, the nonrandom expression of the hormonal phenotype by the neoplastic islet cells, as shown by the immunohistochemical, semiquantitative analysis of a large number of tumors, suggests that in our MEN-I patient the genetically determined neoplasms also are affected by other mechanisms, possibly nongenetic.
journal_name
Cancerjournal_title
Cancerauthors
Pilato FP,D'Adda T,Banchini E,Bordi Cdoi
10.1002/1097-0142(19880501)61:9<1815::aid-cncr2820subject
Has Abstractpub_date
1988-05-01 00:00:00pages
1815-20issue
9eissn
0008-543Xissn
1097-0142journal_volume
61pub_type
杂志文章相关文献
CANCER文献大全abstract::Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871115)60:10<2465::aid-cncr282
更新日期:1987-11-15 00:00:00
abstract::Between August 1978 and November 1981, 33 boys with acute lymphocytic leukemia (ALL) (26 non-T, 7 T-cell) younger than 16 years underwent bilateral wedge testicular biopsies at the time of initial diagnosis. Seven (4 non-T, 3 T-cell) demonstrated focal leukemic infiltrates. Rebiopsy after successful induction therapy ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860301)57:5<1038::aid-cncr2820
更新日期:1986-03-01 00:00:00
abstract::Growth kinetics of 102 breast carcinomas were studied by immunohistochemical analysis with the monoclonal antibody Ki-67, which reacts with a nuclear antigen in proliferating cells. The results were correlated with ploidy and S-phase fraction (SPF) analyzed by DNA flow cytometric study and with mitotic count analyzed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900301)65:5<1180::aid-cncr2820
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c
更新日期:1999-06-01 00:00:00
abstract::Two patients with superior vena cava syndrome (SVCS) recurring after maximum-tolerance radiation were treated by placing a Gianturco expandable wire stent (GEWS) into the obstructed superior vena cava. The SVCS symptoms rapidly disappeared and good short-term (6 months) palliation was achieved. GEWS placement is a pro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1243::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract:BACKGROUND:An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT). METHODS:Patients were stratified as follows: stra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22241
更新日期:2006-11-01 00:00:00
abstract::A primary yolk-sac (endodermal sinus) tumor of the prostate occurring in a 51-year-old man is described, and the difficulties associated with classification of this tumor are discussed. Yolk-sac tumors have been reported to arise in several extragonadal sites, but to our knowledge this is the first documented case of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197804)41:4<1395::aid-cncr282041
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) play a crucial role in carcinogenesis; however, it largely remains unclear whether miRNAs in gastric juice, which is specific for gastric tissues, can be used as biomarkers for gastric cancer. The objective of the current study was to investigate the feasibility of using gastric juice miRN...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27903
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:A hypothesis generated a retrospective analysis of the improvement of survival over time in patients with cutaneous melanoma (CM) in order to identify factors contributing to this progress. METHODS:A cohort of 4791 patients diagnosed with primary CM in southern Germany between 1976 and 2001 was analyzed. Ka...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22511
更新日期:2007-03-15 00:00:00
abstract:BACKGROUND:The authors undertook a prospective evaluation of the clinical value of 2-fluoro [18-]-2-deoxyglucose positron emission tomography (FDG-PET) in the detection and staging of malignant lymphoma compared with computed tomography (CT) and bone marrow biopsy (BMB). METHODS:Fifty-two consecutive patients with unt...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2001-03-01 00:00:00
abstract::Forty patients with disseminated malignant melanoma were treated with triple combination chemotherapy consisting of Imidazole Carboxamide, BCNU and Vincristine. Seventeen of 40 patients (42.5%) showed significant responses including three complete responses. Responses were seen in cutaneous, lymph node and pulmonary m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197701)39:1<41::aid-cncr28203901
更新日期:1977-01-01 00:00:00
abstract::All patients with a diagnosis of cutaneous malignant melanoma (CMM) in Western Australia from 1980 to 1981 were observed for up to 6 years to determine vital status and to detect the development of local recurrences of the primary lesion. Approximately 35% of all patients had their tumors excised with surgical margins...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920115)69:2<421::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract:BACKGROUND:A Phase II prospective trial was performed to study the efficacy of combination therapy with dexamethasone, calcitriol (1,25-dihydroxyvitamin D3), and carboplatin in patients with hormone-refractory prostate cancer (HRPC). Preclinical data from prostate cancer cell lines suggested a synergistic effect of the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21982
更新日期:2006-07-15 00:00:00
abstract::The results of assay for estrogen receptor (ER) in the tumor cytosol and thymidine labeling indices (TLI) of 63 primary invasive carcinomas of the breast were analyzed. The ER assay was performed by using dextran-charcoal to adsorb unbound tritiated estradiol-17beta (E2) in cytosol. The TLI was measured as the number ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197711)40:5<2290::aid-cncr282040
更新日期:1977-11-01 00:00:00
abstract::Computed tomography (CT) has emerged from the 1980s to play a dominant role in the pretreatment staging of renal and adrenal carcinomas. For detection, definition (staging), and determination of resectability or recurrence, CT with intravenous contrast enhancement, and more recently, magnetic resonance imaging (MRI) w...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910215)67:4+<1199::aid-cncr282
更新日期:1991-02-15 00:00:00
abstract::Eighty-one female patients with phyllodes tumors of the breast, surgically treated from 1974 to 1983, were studied. Their age ranged from 9 to 88 years. According to histology, the series was divided into three groups, of 28 (34.5%) benign tumors, 32 (39.5%) border-line tumors, and 21 (25.9%) malignant tumors. Because...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890615)63:12<2532::aid-cncr282
更新日期:1989-06-15 00:00:00
abstract::The 136 patients who underwent total laryngectomy as the primary treatment for squamous cell carcinoma of the glottis at the Mayo Clinic in 1970 through 1981 were followed by retrospective record review for at least 4 years or until death, local recurrence, neck recurrence, or delayed neck metastasis. Cancer recurred ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890701)64:1<143::aid-cncr28206
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:China's lung cancer (LC) burden plays a pivotal role in the global cancer epidemic. Comparing LC burden and population attributable fractions (PAFs) of risk factors between China and other countries/regions is essential to inform effective intervention. The Global Burden of Disease (GBD) study provides a uni...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33078
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant chemotherapy after surgical resection administered exclusively in older patients. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29360
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Although Kaposi sarcoma (KS) initially was described over a century ago, its biology remains enigmatic and conflicting. Whereas the classic type occurs mainly in older men of Mediterranean or Eastern European backgrounds and is not linked to impairment of the host immune response, iatrogenic and human immuno...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::The possible effect of oral contraceptive (OC) use on the prognosis of established breast cancer was investigated in 154 young women aged 35 and younger. No significant differences were found between the study group of 59 OC users, and the control group of 95 nonusers in age, parity and gravidity, family history of br...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850401)55:7<1556::aid-cncr2820
更新日期:1985-04-01 00:00:00
abstract::Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<245::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract:BACKGROUND:Neurofibroma of the urinary bladder is rare. Only isolated case reports have appeared. Information regarding the long term follow-up of patients with neurofibroma is limited. METHODS:The authors studied 4 cases of neurofibroma of the bladder diagnosed at Mayo Clinic from 1965 through 1990. Immunostains for ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-08-01 00:00:00
abstract::Over the years, there has been a continuous increase in clinically relevant driver mutations in patients with non-small cell lung cancer (NSCLC). Among these, dysregulated activation of the MET tyrosine kinase receptor has gained importance due to the recent development of quite effective treatments. MET dysregulation...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.33159
更新日期:2020-11-15 00:00:00
abstract:BACKGROUND:There is global variation in the onset of hepatocellular carcinoma (HCC). The objective of the current study was to investigate the impact of country of birth on age at the time of HCC diagnosis in the United States. METHODS:Incident HCC cases diagnosed between 2000 and 2012 in the Surveillance, Epidemiolog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30246
更新日期:2017-01-01 00:00:00
abstract::This protocol study (SWOG-7431) combining adriamycin and methyl CCNU (MAD) for metastatic sarcomas was initially used on patients who were refractory to cytoxan, vincristine, and/or actinomycin-D. After the initial good results, the study was expanded to include any untreated patients with metastatic sarcoma. The init...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800801)46:3<446::aid-cncr28204
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Validation of the prognostic indices for the recurrence-free interval of patients with parotid carcinoma, the development of which was described in a previous report, is needed to be confident of their generalizability and justified prospective use. METHODS:The Dutch Cooperative Group on Head and Neck Cance...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11254
更新日期:2003-03-15 00:00:00
abstract:BACKGROUND:Conditional survival is clinically useful, particularly for patients with malignant disease who have a poor prognosis. However, there are no published data on the conditional median survival of patients with advanced carcinoma on a population basis. METHODS:Data on 217,573 patients with breast, colorectal, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011015)92:8<2211::aid-cncr1565
更新日期:2001-10-15 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(20010201)91:3<484::aid-cncr1026>
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:It is believed that in the early stages of hepatocarcinogenesis, some adenomatous hyperplasias (AH) progress to early hepatocellular carcinoma (eHCC), and that many eHCC develop into overt hepatocellular carcinoma (HCC) through nodule-in-nodule formation. However, the proliferative activity of these small no...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940115)73:2<289::aid-cncr28207
更新日期:1994-01-15 00:00:00