Abstract:
BACKGROUND:Ribonucleotide reductase M1 (RRM1) is an important molecule in different types of cancer. The objective of this study was to evaluate the predictive roles of RRM1 in the survival of patients with resectable pancreatic adenocarcinoma who received treatment with gemcitabine or nongemcitabine adjuvant therapy. METHODS:In total, 122 patients underwent tumor resection for pancreatic adenocarcinoma at the authors' institution from October 1999 to December 2007. Total RNA was isolated from microdissected, paraffin-embedded tumors. RRM1 expression levels were measured using quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) and were dichotomized using recursive partitioning analysis. The Kaplan-Meier method was used to estimate overall survival and progression-free survival, and the predictive value of RRM1 expression on survival was examined using Cox proportional hazards regression. RESULTS:RRM1 expression did not have significant prognostic value in the entire cohort regarding overall survival (P = .2) or progression-free survival (P = .7). In the subgroup of 44 patients who received adjuvant gemcitabine, patients who had low RRM1 expression had longer overall survival (median, 47.8 months vs 14.1 months; P = .005) and a trend toward longer progression-free survival (median not reached vs 12.9 months; P = .06). In contrast, in the subgroup of 35 patients who received nongemcitabine adjuvant therapy, patients who had high RRM1 expression had significantly longer overall survival (median, 41.9 months vs 19.8 months; P = .01) and progression-free survival (median, 70.0 months vs 11.8 months; P = .04). These results were confirmed in Cox proportional hazards multivariable analysis. CONCLUSIONS:In patients with resectable pancreatic adenocarcinoma, low RRM1 expression in the tumor predicted an overall survival benefit of adjuvant gemcitabine; and high RRM1 expression predicted the survival benefit of nongemcitabine adjuvant therapy.
journal_name
Cancerjournal_title
Cancerauthors
Xie H,Jiang W,Jiang J,Wang Y,Kim R,Liu X,Liu Xdoi
10.1002/cncr.27715subject
Has Abstractpub_date
2013-01-01 00:00:00pages
173-81issue
1eissn
0008-543Xissn
1097-0142journal_volume
119pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:To explore the potential role of infiltrating benign B cells in classic Hodgkin disease (HD) lesions in supporting the survival of malignant Hodgkin and Reed-Sternberg (H/RS) cells, the authors initiated a pilot study of rituximab. Rituximab is used to primarily deplete normal B cells from HD lesions. METHO...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11511
更新日期:2003-07-15 00:00:00
abstract::Oral submucous fibrosis (OSF) is a chronic disease of the oral mucosa characterized by inflammation and a progressive fibrosis of the lamina propria and deeper connective tissues. It is a condition predominantly seen among people of Indian origin, and an epidemiologic survey done a decade ago showed no less than 250,0...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920415)69:8<2011::aid-cncr2820
更新日期:1992-04-15 00:00:00
abstract::To surgery, radiation, and chemotherapy for cancer has been added a fourth modality: multidisciplinary therapy, which is improving the survival and cure rate among children. Specialists working together in a coordinated effort suspect, confirm, then treat cancer; follow and rehabilitate the patient; analyze and report...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3+<876::aid-cncr282035
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:LAMP3 is a newly described hypoxia regulated gene of potential interest in hypoxia-induced therapy resistance and metastasis. The prognostic value of LAMP3 in breast cancer was investigated. METHODS:Expression levels of LAMP3 in breast cancer cell lines and patient tissues were determined by real-time polym...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25938
更新日期:2011-08-15 00:00:00
abstract::Fatigue has been described as the most common, most debilitating side effect of cancer treatment and is frequently reported as a long-term complication of treatment as well. Despite the prevalence of fatigue and its profoundly negative effect on patients' quality of life, little is known about the specific mechanisms ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20010915)92:6+<1699::aid-cncr150
更新日期:2001-09-15 00:00:00
abstract::Although improvements in the management of adults with acute leukemia have lagged behind those seen in the treatment of children, there are clear reasons for optimism. Combination chemotherapy for acute myeloblastic leukemia (AML) and acute lymphoblastic leukemia (ALL) in adults results in complete remissions in 50-85...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12+<2460::aid-cncr28
更新日期:1983-06-15 00:00:00
abstract::The case of a European patient with a malignant lymphoepithelial lesion of epithelial type is presented. This type of tumor has an exceptionally high incidence among Eskimos. To the authors' knowledge this is the first case reported with an ultrastructural study that demonstrates the squamous nature of the tumor cells...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<289::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract:BACKGROUND:While acute pancreatitis is a recognized complication of numerous drugs, cytarabine's role in causing this complication is controversial. Approximately 15 cases have been reported to the Food and Drug Administration linking cytarabine with pancreas-related toxicities. Previous case reports have been complica...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960615)77:12<2588::AID-C
更新日期:1996-06-15 00:00:00
abstract::Identification of BCR-ABL as the defining leukemogenic event in chronic myelogenous leukemia (CML) revolutionized the treatment of the disease. Imatinib, a potent BCR-ABL inhibitor, is the standard of care for the first-line treatment of patients with chronic-phase CML because of its high long-term response rates and ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24928
更新日期:2010-03-15 00:00:00
abstract::Bladder cancer is one of the malignancies for which considerable information is available regarding molecular pathogenesis and genetic predictors of natural history, as well as response to treatment. Loss of heterozygosity of chromosome 9 appears to be essential to the genesis of superficial bladder cancer, and mutati...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.11281
更新日期:2003-04-15 00:00:00
abstract:BACKGROUND:Cyclin-dependent kinases (CDK) and cyclins constitute the subunits of the maturation-promoting factor that controls the process of cell division. High levels of these proteins have been reported in human malignancies of the stomach, colon, breast, and lung, and have been implicated in aberrant cell division ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970815)80:4<753::aid-cnc
更新日期:1997-08-15 00:00:00
abstract:BACKGROUND:Serum alpha-L-fucosidase activity is considered a marker of hepatocellular carcinoma. To the authors' knowledge, its clinical usefulness in the early detection of hepatocellular carcinoma in the follow-up of cirrhotic patients has not been reported previously. METHODS:The authors prospectively studied serum...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-12-15 00:00:00
abstract::A 49-year-old white woman with refractory anemia subsequently developed acute myelomonocytic leukemia with paraproteinemia 12 months later. The paraprotein was characterized as immunoglobulin G, type kappa, and the Bence Jones protein as free kappa chains. Further studies, including electron microscopy, cytochemistry,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1359::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract::Available information suggests that individuals with breast cancer gain weight during adjuvant treatment and that this weight gain may be associated with poor prognosis. Exploration of the factors which affect weight gain may aid in developing weight control interventions for these patients. To determine the factors w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910401)67:7<1954::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:The lack of comparable metrics to evaluate prevention and early detection patient navigation programs impeded the ability to identify best practices. METHODS:The Prevention and Early Detection Workgroup of the Patient Navigation Leadership Summit was charged with making recommendations for common clinical m...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26267
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS:The association between lung carcinoma risk an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11242
更新日期:2003-04-01 00:00:00
abstract::The ultrastructure of a chondroid syringoma is described. The tumor nests are formed by clumps, solid cords and tubular structures distributed diffusely throughout a stroma of varying density. Two different types of cells form this tumor: dark cells forming the inner layer of the tubuloalveolar and ductal structures a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197907)44:1<148::aid-cncr2820440
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:Information regarding prognostic factors and survival in elderly women with metastatic breast cancer treated with tamoxifen is limited. METHODS:The data from 4 prospective clinical trials were analyzed, including information on 396 postmenopausal women with advanced breast cancer who received tamoxifen as i...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0142(19960215)77:4<683::aid-cnc
更新日期:1996-02-15 00:00:00
abstract::Human prostate specimens from 25 patients provided 15 normal, four benign prostatic hypertrophy (BPH), and seven adenocarcinoma samples which were studied using a polyclonal antibody against prostatic specific antigen (PSA) and protein A-gold complex. Our study showed the presence of gold particles in cytoplasmic vesi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870915)60:6<1288::aid-cncr2820
更新日期:1987-09-15 00:00:00
abstract::The authors present a retrospective review of 90 cases of Stage III endometrial carcinoma seen over a 10-year period at the Princess Margaret Hospital, Toronto. Overall 5-year survival was 45.5% and disease-free survival was 36.0%. Prognostic factors identified within Stage III were tumor grade, geographic distributio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851115)56:10<2519::aid-cncr282
更新日期:1985-11-15 00:00:00
abstract::Many investigators have regarded Stage III lymphomas as a generalized form of disease and have accordingly recommended systemic treatment programs. Between 1961 and 1973, 68 patients with clinical or pathologic Stage III non-Hodgkin's lymphomas were seen in the Division of Radiation Therapy at Stanford University Medi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197606)37:6<2806::aid-cncr282037
更新日期:1976-06-01 00:00:00
abstract:BACKGROUND:An increase in resting energy expenditure (REE) is considered to contribute to the weight loss experienced by patients with cancer. However, alternations in basal metabolism vary among patients with different neoplasms. REE in patients with hepatocellular carcinoma (HCC), a common malignant tumor in Taiwan, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940201)73:3<590::aid-cncr28207
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Primary lymphomas of the uterus or cervix are so rare that treatment series of single institutions consist of very small numbers of patients, making standard treatment difficult to define. The outcome of patients treated with a combination of chemotherapy and radiation therapy was analyzed for all but patien...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950501)75:9<2392::aid-cncr2820
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Parathyroid hormone-related protein (PTHrP) has been shown to be the principal cause of humoral hypercalcemia associated with renal cell carcinoma (RCC). Recent studies have demonstrated that the amino-terminal region of PTHrP has growth factor-like activities, suggesting it may play a role in the developmen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990915)86:6<1028::aid-cn
更新日期:1999-09-15 00:00:00
abstract::We counted the number of toluidine blue positive mast cells within and around the tumor in 44 patients with soft tissue sarcomas (STS). Irrespective of their histologic types, these cases were broadly divided into the following two groups: (1) low count (less than 20 mast cells/10 high-power fields [HPF]) and (2) high...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881201)62:11<2416::aid-cncr282
更新日期:1988-12-01 00:00:00
abstract::Forty-nine specimens of carcinoma of the breast were analyzed for estrogen receptor content using the sucrose gradient method and a histochemical method using a conjugate of estradiol (6-BSA-Fluor-CMO-17 beta-estradiol). The specimens analyzed by the histochemical method were graded for fluorescent intensity, percenta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820515)49:10<2148::aid-cncr282
更新日期:1982-05-15 00:00:00
abstract::Cases of childhood cancer (less than 15 years of age at diagnosis), diagnosed between 1960 and 1984, were obtained from the Hawaii Tumor Registry, a population-based Surveillance, Epidemiology, and End Results (SEER) participant covering the entire State of Hawaii. During the 25 years of data collection, cancer was di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891015)64:8<1758::aid-cncr2820
更新日期:1989-10-15 00:00:00
abstract::Ultrastructural examination of an alveolar rhabdomyosarcoma revealed that the bulk of the tumor was composed of small polygonal cells containing polyribosomes, short strands of rough endoplasmic reticulum, and variable amounts of glycogen; the cells were joined by small desmosome-like structures. Similar cells, as wel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197804)41:4<1355::aid-cncr282041
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Because the prostatic capsule is often indistinct, recognition of extraprostatic extension by carcinoma depends heavily on the identification of carcinoma cells in the periprostatic adipose tissue. However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively. MET...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11231
更新日期:2003-04-01 00:00:00
abstract::A case of pancreatoblastoma, arising in the tail of the pancreas with metastases to the right radius, in an 8-year-old boy is reported. The serum alpha-fetoprotein (AFP) level was over 13 times the normal value before surgery, but returned to normal after removal of the primary tumor. Furthermore, AFP was detected in ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860501)57:9<1833::aid-cncr2820
更新日期:1986-05-01 00:00:00