Abstract:
:The cytogenetic findings in 31 liposarcomas from 26 patients are reported. Four other tumors did not grow. Three histologic types are represented in this analysis. The well-differentiated liposarcomas were characterized by telomeric associations, large marker chromosomes and ring chromosomes, and in some cases, double minutes. The pleomorphic liposarcomas contained very high clonal chromosomal numbers with near-tetraploid modes and numerous variable, often unidentifiable, chromosomal abnormalities. The myxoid liposarcomas were characterized primarily by a t(12;16)(q13;p11) as the sole abnormality or additional changes. These results indicate that cytogenetic findings may provide a new criterion, not only for establishing the diagnosis of liposarcoma, but also for differentiating confusing histologic types of liposarcoma and these lesions from other types of sarcomas.
journal_name
Cancerjournal_title
Cancerauthors
Sreekantaiah C,Karakousis CP,Leong SP,Sandberg AAdoi
10.1002/1097-0142(19920515)69:10<2484::aid-cncr282subject
Has Abstractpub_date
1992-05-15 00:00:00pages
2484-95issue
10eissn
0008-543Xissn
1097-0142journal_volume
69pub_type
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