Abstract:
:High dose methotrexate followed by citrovorum factor reversal has been utilized in twenty-six patients with advanced cancer. Four of 10 patients with head and neck cancer had an objective response. One of 7 patients with metastatic osteosarcoma to the lungs had stabilization with twenty treatments over 23 months. One patient with acute lymphocytic leukemia developed marrow aplasia but did not attain remission. The regimen was well tolerated when meticulous attention was paid to hydration, urine alkalinization, renal function and third space fluid accumulation. Life-threatening or lethal toxicity was encountered when these phenomena were not scrupulously observed.
journal_name
Cancerjournal_title
Cancerauthors
Ambinder EP,Perloff M,Ohnuma T,Biller HF,Holland JFdoi
10.1002/1097-0142(197904)43:4<1177::aid-cncr282043subject
Has Abstractpub_date
1979-04-01 00:00:00pages
1177-82issue
4eissn
0008-543Xissn
1097-0142journal_volume
43pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Hypercalcemia has rarely been reported in patients with Richter's syndrome (RS). In this article, the authors report four cases with complementary pathophysiologic examinations. METHODS:Four patients with hypercalcemia that indicated RS were admitted to the study unit between 1980 and 1994 with the followin...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-15 00:00:00
abstract::This article describes the clinicopathologic features of six cases of uterine papillary serous carcinoma (UPSC), which developed several years after radiation therapy (RT) for cervical carcinoma. The possible etiologic role of radiation is discussed, and the literature on endometrial carcinomas developing after RT is ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920115)69:2<496::aid-cncr28206
更新日期:1992-01-15 00:00:00
abstract:BACKGROUND:Screening colonoscopy (SC) for colorectal cancer (CRC) is underused by Latino individuals. The current randomized clinical trial examined the impact of 3 interventions: 1) patient navigation; 2) patient navigation plus standard Centers for Disease Control and Prevention print materials; and 3) patient naviga...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.32541
更新日期:2020-02-15 00:00:00
abstract:BACKGROUND:The current study determined the efficacy and toxicity of weekly paclitaxel in combination with estramustine phosphate (EMP) in patients with androgen-independent prostate carcinoma (AIPC). METHODS:Patients with progressive AIPC received 90 mg/m2 paclitaxel by 1-hour intravenous infusion weekly for 3 weeks,...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.11956
更新日期:2004-02-15 00:00:00
abstract:BACKGROUND:Patients with advanced cancer often experience frequent and prolonged hospitalizations; however, the factors associated with greater health care utilization have not been described. We sought to investigate the relation between patients' physical and psychological symptom burden and health care utilization. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30912
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Nipple duct lavage (NDL) may be useful for breast cancer risk stratification. Published guidelines recommend that women with a 5-year Gail risk >/=1.7% should consider undergoing lavage for any fluid-yielding ducts, but it is not known whether increased breast cancer risk or nipple fluid production predict l...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22538
更新日期:2007-04-01 00:00:00
abstract::Tumor-associated antigens (TAA) excreted into the urine of sarcoma patients can be detected by the complement-fixation assay. The authors prospectively measured TAA levels in the urine of 50 sarcoma patients postoperatively to determine whether reappearance of antigen in the urine would be predictive of disease recurr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840315)53:6<1306::aid-cncr2820
更新日期:1984-03-15 00:00:00
abstract:BACKGROUND:Historically, patients with nonmetastatic renal cell carcinoma (RCC) involving adjacent organs have been considered inoperable and incurable. The oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of RCC patients. Further, an attempt was made to define the clinica...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22629
更新日期:2007-05-15 00:00:00
abstract:BACKGROUND:The Tecumseh Community Health Study (TCHS), initiated in 1959 at the University of Michigan School of Public Health, has provided a resource for long term prospective studies of the incidence of cancer in the setting of a midwestern rural farming community. METHODS:A survey of total and site specific cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.1996.2820770402
更新日期:1996-02-15 00:00:00
abstract::A previously unreported association of Brenner and adenomatoid tumor found in the tunica vaginalis testis is presented. Many ultrastructural features found in mesothelial cells such as intercellular spaces, deeply indented nuclei, tonofilaments and tight desmosomes, were also shared by cells present in both neoplastic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197902)43:2<539::aid-cncr2820430
更新日期:1979-02-01 00:00:00
abstract::Bladder cancer is one of the malignancies for which considerable information is available regarding molecular pathogenesis and genetic predictors of natural history, as well as response to treatment. Loss of heterozygosity of chromosome 9 appears to be essential to the genesis of superficial bladder cancer, and mutati...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.11281
更新日期:2003-04-15 00:00:00
abstract::Twenty-five patients with advanced measurable adenocarcinoma of the lung were treated with combination chemotherapy consisting of 5-fluorouracil, adriamycin, and mitomycin-C (FAM). Objective response (1CR, 8PR) was obtained in 36% of patients. The median duration of response was 7.0 months and the median survival for ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1183::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:The improved efficacy of imipenem over other beta-lactam antibiotics in the treatment of febrile neutropenic patients has been attributed to its broad spectrum of activity. METHODS:A prospective, randomized, clinical trial was performed comparing vancomycin 1 g every 12 hours plus imipenem/cilassatin 500 mg...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(SICI)1097-0142(19960401)77:7<1386::AID-CN
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:The combination of a platinating agent and etoposide has induced responses in various pediatric tumors. The study estimated the maximum tolerated dose (MTD) of an oxaliplatin and etoposide regimen in children with recurrent solid tumors. METHODS:Oxaliplatin was administered on Day 1 and etoposide on Days 1 ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24054
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:To describe continuing care and rehabilitation needs of cancer patients, a longitudinal design (6 months) was performed among patients 50 years of age and older with solid tumors. The study examined how age, type of treatment, site of cancer, and symptom experience affect physical functioning and their menta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941001)74:7+<2128::aid-cncr282
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:To evaluate the hearing preservation rate and to determine its prognostic factors after gamma knife (GK) stereotactic radiosurgery (SRS) in patients with vestibular schwannoma, the authors used a prospective study design to analyze these patients. METHODS:Between December 1997 and January 2002, 25 patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21190
更新日期:2005-08-01 00:00:00
abstract::The case of a European patient with a malignant lymphoepithelial lesion of epithelial type is presented. This type of tumor has an exceptionally high incidence among Eskimos. To the authors' knowledge this is the first case reported with an ultrastructural study that demonstrates the squamous nature of the tumor cells...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<289::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract::During the past decade, one of the major changes in the field of oncology has been in the surgical approach to primary and secondary cancer of the liver. As a result of data and experience gained in liver transplantation programs and with the application of vascular surgical principles, resectability rates have been i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810501)47:9<2162::aid-cncr2820
更新日期:1981-05-01 00:00:00
abstract::The adolescent and young adult (AYA) oncology population has seen inferior progress in cancer survival compared with younger children and older adults over the past 25 years. Previously, AYAs had the best survival rates due to the prevalence of highly curable diseases including Hodgkin lymphoma and germ cell tumors, y...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23060
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:The National Quality Forum endorses the recommendation of examining at least 12 lymph nodes (LNs) from colorectal cancer (CRC) specimens. However, heterogeneity in LN harvest exists. The objective of this study was to investigate the clinicopathologic factors that influence LN yield. METHODS:The authors use...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25032
更新日期:2010-06-01 00:00:00
abstract::One hundred seventeen postmenopausal advanced breast cancer patients previously untreated with chemotherapy were randomized to receive: cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), CMF and tamoxifen (TMX), and CMF and medroxyprogesterone (MAP). Treatments B and C induced a greater proportion of responses ...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19851215)56:12<2745::aid-cncr282
更新日期:1985-12-15 00:00:00
abstract::A prospective randomized trial by CALGB examined the relative value of four chemotherapy regimens in 537 patients with stage III B and IV Hodgkin's disease. A new combination BOPP, derived by substitution of BCNU for nitrogen mustard in the MOPP regimen, was compared to MOPP and to two 3-drug regimens, derived by remo...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197901)43:1<31::aid-cncr28204301
更新日期:1979-01-01 00:00:00
abstract::Cancer is the second most common cause of death among those aged > or =65 years, and is a major cause of morbidity. There is some evidence that screening, by detecting precancerous lesions in asymptomatic patients, is effective in reducing cancer-related morbidity and mortality among older men and women. The objective...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23938
更新日期:2008-12-15 00:00:00
abstract::Testicular function was studied in 26 men with sarcoma who received adjuvant treatment with doxorubicin, cyclophosphamide, and high-dose methotrexate (with or without radiotherapy). Testicular size, sperm output, and serum FSH, LH and testosterone levels were assessed after treatment. Five of 17 men who received chemo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2368::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract:BACKGROUND:The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. METHODS:A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cance...
journal_title:Cancer
pub_type: 共识发展会议,杂志文章,评审
doi:10.1002/cncr.30380
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Medullary thyroid carcinoma (MTC), a rare malignancy with a variety of morphologic appearances, can mimic both primary and metastatic lesions of the thyroid gland and give rise to diagnostic problems when these tumors are aspirated. Although cytopathologic features of MTC have been well described, this study...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-02-25 00:00:00
abstract:BACKGROUND:There is global variation in the onset of hepatocellular carcinoma (HCC). The objective of the current study was to investigate the impact of country of birth on age at the time of HCC diagnosis in the United States. METHODS:Incident HCC cases diagnosed between 2000 and 2012 in the Surveillance, Epidemiolog...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30246
更新日期:2017-01-01 00:00:00
abstract::Non-Hodgkin's lymphoma confined to the liver is unusual in adults and has not been reported in children. Two children with primary hepatic and one with hepatosplenic NHL are described. All three patients are males, and both tumors examined for cell surface markers were of B-cell origin. Two patients, treated with chem...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831215)52:12<2285::aid-cncr282
更新日期:1983-12-15 00:00:00
abstract:BACKGROUND:Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in the tissue, allow BLM delivery inside the cells, and increase BLM cytotoxicity. As an extension of our initial Phase I...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0142(19960301)77:5<956::aid-cnc
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Chemotherapy intensification may lead to new forms of toxicity such as hemolytic uremic syndrome. METHODS:Three patients are described who developed this complication 4 to 6 months after high dose chemotherapy followed by autologous stem cell support. The literature on this subject is reviewed. RESULTS:One...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19951201)76:11<2338::aid-cncr282
更新日期:1995-12-01 00:00:00