Chemotherapy versus chemotherapy plus hormonotherapy in postmenopausal advanced breast cancer patients. A randomized trial.

Abstract:

:One hundred seventeen postmenopausal advanced breast cancer patients previously untreated with chemotherapy were randomized to receive: cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), CMF and tamoxifen (TMX), and CMF and medroxyprogesterone (MAP). Treatments B and C induced a greater proportion of responses than treatment A. No effect was identified on the number of complete responses. After treatment failure, patients from groups A and C received Adriamycin (doxorubicin) (ADX) vincristine (VCR), and TMX and patients from group B received ADM, VCR, and MAP. No differences were found between the branches in the response rates to the second protocol. Responders to both treatments had a longer survival experience than nonresponders or responders to only one of the treatments. Survival was independent of the treatment group.

journal_name

Cancer

journal_title

Cancer

authors

Viladiu P,Alonso MC,Avella A,Beltrán M,Borrás J,Ojeda B,Bosch FX

doi

10.1002/1097-0142(19851215)56:12<2745::aid-cncr282

subject

Has Abstract

pub_date

1985-12-15 00:00:00

pages

2745-50

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验

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