Abstract:
:From a total of 874 patients with small cell lung cancer (SCC), a series of 104 patients were reviewed to determine if bone marrow relapses are detectable by routine clinical investigations. Autopsy, including microscopical bone marrow examination, was performed in all the 104 patients and bone metastases were disclosed in 36 patients (35%). After retrospective evaluation it was concluded that dose modification, occurrence of leukopenia plus fever, need of blood transfusion, leukopenia, and thrombopenia during treatment all were without predictive value in the detection of bone marrow relapse. Increased concentrations of lactate dehydrogenase and alkaline phosphatase were, however, positively correlated to the finding of bone marrow relapse.
journal_name
Cancerjournal_title
Cancerauthors
Kristjansen PE,Osterlind K,Hansen Mdoi
10.1002/1097-0142(19861201)58:11<2538::aid-cncr282subject
Has Abstractpub_date
1986-12-01 00:00:00pages
2538-41issue
11eissn
0008-543Xissn
1097-0142journal_volume
58pub_type
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