Detection of bone marrow relapse in patients with small cell carcinoma of the lung.

Abstract:

:From a total of 874 patients with small cell lung cancer (SCC), a series of 104 patients were reviewed to determine if bone marrow relapses are detectable by routine clinical investigations. Autopsy, including microscopical bone marrow examination, was performed in all the 104 patients and bone metastases were disclosed in 36 patients (35%). After retrospective evaluation it was concluded that dose modification, occurrence of leukopenia plus fever, need of blood transfusion, leukopenia, and thrombopenia during treatment all were without predictive value in the detection of bone marrow relapse. Increased concentrations of lactate dehydrogenase and alkaline phosphatase were, however, positively correlated to the finding of bone marrow relapse.

journal_name

Cancer

journal_title

Cancer

authors

Kristjansen PE,Osterlind K,Hansen M

doi

10.1002/1097-0142(19861201)58:11<2538::aid-cncr282

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

2538-41

issue

11

eissn

0008-543X

issn

1097-0142

journal_volume

58

pub_type

杂志文章

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