Immunohistologic studies of cytoplasmic immunoglobulins in rheumatic diseases including two patients with monoclonal patterns and subsequent lymphoma.

Abstract:

:Tissue specimens from five patients with rheumatic disease who developed lymphadenopathy were studied by an immunoperoxidase method; available biopsy material was examined for cytoplasmic immunoglobulin determinants. Three patients had follicular hyperplasia of lymph nodes with polyclonal patterns. Two patients with Sjogren's syndrome had monoclonal patterns; both of these patients subsequently developed lymphoma with similar monoclonal patterns. Implications of the monoclonal patterns with regard to the biology of these lymphoproliferative disorders are discussed.

journal_name

Cancer

journal_title

Cancer

authors

Humphrey DM,Cortez EA,Spiva DA

doi

10.1002/1097-0142(19820515)49:10<2049::aid-cncr282

subject

Has Abstract

pub_date

1982-05-15 00:00:00

pages

2049-69

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

49

pub_type

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