Abstract:
BACKGROUND:The authors examined the "real-world" effectiveness of rituximab (R) maintenance therapy (R-maintenance) compared with observation after R-based induction therapy in patients with previously untreated follicular lymphoma (FL) in the United States. METHODS:The National LymphoCare Study is a prospective, multicenter, observational study that enrolled > 2700 untreated patients with FL diagnosed from 2004 to 2007 at 265 sites in the United States. Among these, patients who achieved at least stable disease after R-based induction therapy were eligible for the current analysis. Patients who initiated R-maintenance within 215 days of completing induction therapy were categorized as the R-maintenance group, and those who did not initiate therapy during this period were categorized as the observation group. The objective of the current study was to determine the effect of R-maintenance on progression-free survival (PFS), time to next treatment (TTNT), and overall survival (OS). RESULTS:A total of 1439 patients completed R-based induction therapy, 1186 of whom met all inclusion criteria (541 patients received R-maintenance and 645 patients were observed). Characteristics that were found to be predictive of receiving R-maintenance were histology grade (1/2), Ann Arbor stage of disease (III/IV), geographic region (region other than the West), and practice setting (community practice). With a median follow-up of 5.7 years, R-maintenance was associated with superior PFS (hazards ratio [HR], 0.68; 95% confidence interval [95% CI], 0.56-0.84 [P = .0003]) and TTNT (HR, 0.66; 95% CI, 0.52-0.84 [P = .0007]). No significant difference in OS was observed (HR, 0.81; 95% CI, 0.58-1.14 [P = .23]). CONCLUSIONS:R-maintenance in patients with FL and at least stable disease after R-based induction therapy provided significantly longer PFS and TTNT in comparison with observation, but no significant difference in OS was observed with 5-years of follow-up. This comparative effectiveness study aligns with the results of randomized trials suggesting that similar outcomes occur with R-maintenance in FL with the treatment variations observed in clinical practice.
journal_name
Cancerjournal_title
Cancerauthors
Nastoupil LJ,Sinha R,Byrtek M,Zhou X,Taylor MD,Friedberg JW,Link BK,Cerhan JR,Dawson K,Flowers CRdoi
10.1002/cncr.28659subject
Has Abstractpub_date
2014-06-15 00:00:00pages
1830-7issue
12eissn
0008-543Xissn
1097-0142journal_volume
120pub_type
杂志文章,多中心研究相关文献
CANCER文献大全abstract:BACKGROUND:Primary small cell carcinoma arising in organs other than the lung were thought to be relatively rare. However, with the increasing technical sophistication of pathology departments, tumors with foci of small cell neuroendocrine components are being identified more frequently. The pattern of disease involvem...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941215)74:12<3159::aid-cncr282
更新日期:1994-12-15 00:00:00
abstract::A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in wh...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197802)41:2<682::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract::Both cytogenetic analysis and flow cytometry (FCM) have prognostic efficacy in the analysis of transitional cell carcinoma (TCC) of urinary bladder. To correlate results of the two methods, we studied a unique group of patients whose tumors had undergone prospective conventional cytogenetic analysis. Paraffin blocks o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860415)57:8<1594::aid-cncr2820
更新日期:1986-04-15 00:00:00
abstract:BACKGROUND:Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant chemotherapy after surgical resection administered exclusively in older patients. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29360
更新日期:2015-08-01 00:00:00
abstract::Venous thromboembolism (VTE) is a frequent complication of cancer and cancer treatment and is associated with multiple clinical consequences, including recurrent VTE, bleeding, and an increase in the risk of death. Although the risks associated with VTE have been well recognized in surgical cancer patients, there is a...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24665
更新日期:2009-12-15 00:00:00
abstract:BACKGROUND:Bloody nipple discharge is a significant clue in the detection of ductal carcinoma of the breast. In the past, pathologic diagnoses were obtained exclusively via excision, but recently developed mammoscopic techniques have been found to yield valuable information relating to the diagnosis of intraductal lesi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20657
更新日期:2004-11-15 00:00:00
abstract:BACKGROUND:The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (CRC). beta-catenin up-regulates c-Myc and cyclin D1, which antagonize the association of the cyclin-dependent kinase (Cdk) inhibitor, p27(kip1), with Cdk2, thus allowing cell cycle ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10986
更新日期:2002-12-15 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor-C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor-3 (VEGFR-3). Lymphatic spread is an important prognostic factor in patients with lung adenocarcinoma. The aim of the current study was to determine whether the expression of VEGF-C and VEGFR...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21366
更新日期:2005-10-15 00:00:00
abstract::Census data indicate that Cambodian Americans are economically disadvantaged and linguistically isolated. In addition, cancer registry data show that Southeast Asians experience several cancer-related health disparities (e.g., markedly elevated risks of cervical and liver cancer). The Seattle regional Asian American N...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21515
更新日期:2005-12-15 00:00:00
abstract::A 21-year-old patient, after radiation therapy to the mediastinum for Hodgkin's disease, died six years later of a spinal cord glioma, believed to be caused by irradiation therapy. That the x-ray therapy provoked neoplastic changes seems likely, although it could be coincidental. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800415)45:8<2051::aid-cncr2820
更新日期:1980-04-15 00:00:00
abstract:BACKGROUND:The goal of the current study was to assess the toxicity, safety, and efficacy of pentostatin in patients with T-cell lymphoid malignancies. METHODS:Patients were eligible if they had biopsy-proven T-cell lymphoma or leukemia and failure to respond to previous therapy or an expected complete response rate t...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11899
更新日期:2004-01-15 00:00:00
abstract:BACKGROUND:Natural killer (NK) cells are a group of effector cells that act nonspecifically against tumor cells. The correlation between intratumoral NK cell infiltration and clinicopathologic features remains unclear. METHODS:The authors selected 146 patients with gastric carcinoma who underwent gastrectomy at Kagosh...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Chordoma and chondrosarcoma of the skull base are frequently amalgamated because of similar anatomic location, clinical presentation, and radiologic findings. The chondroid chordoma variant has been reported to carry a better prognosis. The objective of the current study was to investigate the distinctions b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23073
更新日期:2007-12-01 00:00:00
abstract::Delayed cutaneous hypersensitivity to 2,3-dinitrochlorobenzene (DNCB) was tested in 419 patients with malignant melanoma to determine whether DNCB reactivity was associated with prognosis. At the time of definitive surgery, a positive DNCB test was seen in 82% of the patients in State I (regional lymph node histologic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810515)47:10<2446::aid-cncr282
更新日期:1981-05-15 00:00:00
abstract:BACKGROUND:Quantified, human hemoglobin (Hb)-specific, immunochemical fecal occult blood test (IFOBT) measurements are now used for colorectal cancer (CRC) screening. The objective was to evaluate sensitivity and specificity for CRC and advanced adenomatous polyps (APs) by the fecal Hb threshold used to determine a pos...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25012
更新日期:2010-05-01 00:00:00
abstract::With increasing numbers of survivors from cancer at a young age, the issue of fertility preservation has assumed greater importance. This review describes normal ovarian and testicular function and summarizes what is known about the effect of chemotherapy and radiotherapy on the gonads and uterus. All young patients w...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26045
更新日期:2011-05-15 00:00:00
abstract::In 1982, more than 125,000 cancer cases in the United States should be preventable. Every physician should advise all patients to eliminate all tobacco use, moderate alcohol use, avoid the use of drugs which are carcinogenic, minimize sun and x-ray exposure, maintain an ideal weight, and follow a "prudent" diet. Secon...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12+<2430::aid-cncr28
更新日期:1983-06-15 00:00:00
abstract:BACKGROUND:Widespread disparities in care have been documented in women with gynecologic cancer in the United States. This study was designed to determine whether structural barriers to optimal care were present during the preoperative period for patients with gynecologic cancer. METHODS:A retrospective review was con...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29859
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:Hispanics comprise almost one-third of the population of California, are the most rapidly increasing racial/ethnic group in the state, and represent almost one-third of all Hispanics in the U.S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21654
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Children of different racial/ethnic backgrounds have varying risks of cancer. However, to the authors' knowledge, few studies to date have examined cancer occurrence in children of mixed ancestry. METHODS:This population-based case-control study examined cancer among children aged <15 years using linked can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25099
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:Carfilzomib improves survival in patients with recurrent myeloma. Given the strict eligibility criteria in clinical trials, the actual frequency of cardiac adverse events (CAEs) and pulmonary adverse events (PAEs) and the risk factors associated with these AEs in the general population need to be established...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32601
更新日期:2020-02-15 00:00:00
abstract:BACKGROUND:The authors undertook a prospective evaluation of the clinical value of 2-fluoro [18-]-2-deoxyglucose positron emission tomography (FDG-PET) in the detection and staging of malignant lymphoma compared with computed tomography (CT) and bone marrow biopsy (BMB). METHODS:Fifty-two consecutive patients with unt...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Several investigators have reported the ability to establish xenografts in nude mice from children with neuroblastomas, but a correlation of prognosis with this establishment and the growth patterns of the neuroblastomas has not been reported. METHODS:Tumor specimens from 58 children with neuroblastomas wer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931201)72:11<3331::aid-cncr282
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Response rates in chronic myeloid leukemia (CML) are now reported based on the cumulative incidence of a single-time best response. The study aim was to examine the significance of different response criteria for CML on imatinib therapy. METHODS:In all, 276 patients with chronic phase CML on imatinib therap...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23238
更新日期:2008-02-15 00:00:00
abstract:BACKGROUND:Osteosarcoma is the most common malignant bone tumor in children and young people. Efficacy of multiagent MAP (methotrexate, doxorubicin [Adriamycin], cisplatin) chemotherapy may be influenced by multiple cellular pathways. This pilot study aimed to investigate the association of 36 candidate genetic polymor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26472
更新日期:2012-04-01 00:00:00
abstract::The clinical course of melanoma of the skin diagnosed during pregnancy was compared with a control population of women with melanoma that occurred during the childbearing years, as recorded by the Connecticut Tumor Registry. The survival at three and five years for the 12 patients whose melanoma developed during pregn...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<407::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract:BACKGROUND:Poor accrual to cancer clinical trials may contribute to the lower improvement in survival observed for adolescents and young adults (AYAs) (those aged 15-39 years) with cancer. This has been difficult to quantify without reliable mechanisms to link incident cases with study enrollments. Using unique resourc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29669
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:The authors conducted a comprehensive review of the efficacy of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) in the detection of primary tumors in patients with disseminated carcinoma of unknown primary site. METHODS:Ten studies (involving a total of 221 patients) tat were publish...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.22410
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:The demonstration of the monoclonality of immunoglobulin heavy chain (IgH) gene rearrangement is an indispensable method for the diagnosis of B-cell lymphoma as well as histocytochemical analysis. For the detection of IgH gene rearrangement, the extraction of DNA from a homogenous cell population is necessar...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.11331
更新日期:2003-08-25 00:00:00
abstract::Clinicians can shed new light on the genetic and environmental origins of cancer, particularly multiple primary malignancies, by asking additional questions at the bedside. Areas to explore include occupational history, personal habits, residence, and medical and family histories with emphasis on subtle clues of disor...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197710)40:4+<1867::aid-cncr28204
更新日期:1977-10-01 00:00:00