Abstract:
:In 1982, more than 125,000 cancer cases in the United States should be preventable. Every physician should advise all patients to eliminate all tobacco use, moderate alcohol use, avoid the use of drugs which are carcinogenic, minimize sun and x-ray exposure, maintain an ideal weight, and follow a "prudent" diet. Secondary prevention efforts would include the American Cancer Society recommendations for the early detection of cancer in asymptomatic persons. Worldwide epidemiologic studies suggest that over 80% of human cancer is due to factors in the environment such as diet, life style, and synthetic chemical contaminants, and perhaps a complex interaction of factors including genetic susceptibility. Current research into the mechanisms of carcinogenesis and in the role of diet in cancer cause, are underway. Chemoprevention of cancer may someday be possible using retinoids, vaccines, and diet alteration.
journal_name
Cancerjournal_title
Cancerauthors
McKenna RJdoi
10.1002/1097-0142(19830615)51:12+<2430::aid-cncr28subject
Has Abstractpub_date
1983-06-15 00:00:00pages
2430-9issue
12 Suppleissn
0008-543Xissn
1097-0142journal_volume
51pub_type
杂志文章相关文献
CANCER文献大全abstract::A series of consecutive trials were undertaken to determine whether higher doses of intravenous metoclopramide and combinations of metoclopramide, dexamethasone, and diphenhydramine would improve antiemetic control or decrease treatment-related side effects in patients receiving cisplatin at 120 mg/m2. Metoclopramide ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19850201)55:3<527::aid-cncr28205
更新日期:1985-02-01 00:00:00
abstract::The prognostic importance of various factors was analyzed for 347 patients registered by the Mycosis Fungoides Cooperative Group (MFCG). Extent of skin involvement at the time of registration and number of sites of clinically enlarged lymph nodes were clearly the most important prognostic variables, and were combined ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810601)47:11<2671::aid-cncr282
更新日期:1981-06-01 00:00:00
abstract::The case of a man who developed a leiomyosarcoma in association with a surgically created arteriovenous fistula is reported. This unusual complication of a dialysis fistula is the first reported case of a leiomyosarcoma occurring in a surgically created fistula. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830715)52:2<390::aid-cncr28205
更新日期:1983-07-15 00:00:00
abstract::The authors evaluated specific gamma-GTP isoenzyme (specific gamma-GTP) found in sera of patients with hepatocellular carcinoma (HCC). In addition to band II and II' which had been reported in our previous publication, band I' also had a high specificity for HCC. One or more of these bands were detectable in 109 (55%)...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830115)51:2<327::aid-cncr28205
更新日期:1983-01-15 00:00:00
abstract:BACKGROUND:Few previous articles have analyzed the relation between infection with Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. METHODS:Resected and biopsied specimens from 237 patients with primary gastric lymphoma were investigated for H. pylori using hematoxylin and eo...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Dual tracer scintigraphy (DTS) (technetium 99m [99mTc] sulfur colloid and gallium 67 citrate [67 gallium citrate]) of the liver and computer subtraction studies (SS) were performed in 26 patients subsequently proven to have hepatocellular carcinoma (HCC) and 32 patients with cirrhosis and focal defects on the colloid ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880215)61:4<667::aid-cncr28206
更新日期:1988-02-15 00:00:00
abstract::Fifty-seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820
更新日期:1985-11-01 00:00:00
abstract::Interest in the elderly population, persons 65 years of age or older, as a target group for cancer control has not been great. Age recommendations rarely are made for prevention and early detection of cancer for elderly persons. However, cancer incidence and mortality rates are known to rise rapidly with increasing ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881015)62:1+<1823::aid-cncr282
更新日期:1988-10-15 00:00:00
abstract:BACKGROUND:The incidence of hepatocellular carcinoma (HCC) has been rising rapidly in the United States. California is an ethnically diverse state with the largest number of incident HCC cases in the country. Characterizing HCC disparities in California may inform priorities for HCC prevention. METHODS:By using data f...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31598
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:A previous study found that medroxyprogesterone acetate (MPA) delayed the in vivo growth of three (AsPC-1, Capan-2, and MiaPaCa-2) of nine human pancreatic carcinoma cell lines transplanted into nude mice (Cancer 1995; 75:1263-72). The current study was undertaken to evaluate the basis for this inhibitor. M...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:The results of a Phase II study of concurrent chemotherapy and accelerated fractionation radiation therapy followed by surgical resection for patients with both adenocarcinoma and squamous cell carcinoma of the esophagus are presented. Pretreatment and postinduction staging were correlated with pathologic fi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-09-15 00:00:00
abstract:BACKGROUND:Approximately 30% of breast carcinoma patients with negative lymph nodes die of their disease. Biologic markers such p53 protein and c-erb B-2 have been related to tumor progression, but their prognostic value remains controversial. METHODS:Two large series of a total of 613 lymph node negative breast carci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000215)88:4<804::aid-cnc
更新日期:2000-02-15 00:00:00
abstract::Cancer of the penis is infrequent in the United States because of good genital hygiene and circumcision of male babies at birth. In other countries, it represents 11-12% of all cancer in males. Tumors of the penis consist mainly of squamous cell carcinoma. Mesenchymal tumors are rare. The treatment is based on the sur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.1980.45.s7.1973
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:Increasing knowledge of cancer genomes has triggered the development of specific targeted inhibitors, thus providing a valuable therapeutic pool. METHODS:In this report, the authors analyze the presence of targetable alterations in 136 tumor samples from 92 patients with melanoma using a comprehensive appro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31843
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Health insurance is a key mediator of health care disparities. Outcomes in bladder cancer, one of the costliest diseases to treat, may be especially sensitive to a patient's insurance status. METHODS:The Surveillance, Epidemiology, and End Results registry and the National Cancer Data Base were used to iden...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32562
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Cyclins, cyclin dependent kinases (cdks), and their inhibitors act in combination to regulate progression through the cell cycle and often are dysregulated in carcinoma. The authors hypothesized that cyclin E plays an important role in ovarian carcinogenesis and that its overexpression may be an indicator of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21767
更新日期:2006-05-01 00:00:00
abstract::Three patients had supratentorial malignant brain tumors 7 to 9 years after prophylactic central nervous system (CNS) treatment for acute lymphocytic leukemia or malignant T-cell lymphoma. Therapy was administered at the age of 3 to 8 years and included cranial irradiation (total dose, 1800 to 2400 cGy) and intratheca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920501)69:9<2385::aid-cncr2820
更新日期:1992-05-01 00:00:00
abstract::In order to validate xenografted small cell lung carcinomas (SCLC) for biological studies, the authors established 12 lung neuroendocrine (NE) tumors (eight typical SCLC and four atypical NE tumors [ANE]) by heterotransplantation onto nude mice. Their characterization was performed using serial ultrastructural, enzyma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890915)64:6<1238::aid-cncr2820
更新日期:1989-09-15 00:00:00
abstract:BACKGROUND:: Survival rates for gastrointestinal (GI) and bronchopulmonary (BP) neuroendocrine tumors (NETs) have not altered significantly (5-year survival rate: GI NETs, 64.1%; BP NETs, 87%-89%) in 30 years (from 1973 to 2004). No effective or specific antineoplastic agents are available to date, although somatostati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24533
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Because of morphologic similarities, the differential diagnosis of granulocytic sarcoma (GS) in fine-needle aspiration (FNA) specimens includes non-Hodgkin or Hodgkin lymphoma, extramedullary hematopoiesis, poorly differentiated carcinoma, and infection. METHODS:Twenty-six FNAs and 1 pleural effusion fluid ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-12-25 00:00:00
abstract:BACKGROUND:To optimize fotemustine chemotherapy, the authors considered how to combine independent Phase II trials to predict the risk of first occurrence of severe toxicity as a function of initial patient characteristics. METHODS:Clinical data from six Phase II trials were collected. Of the 478 patients enrolled 442...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:
更新日期:1996-11-01 00:00:00
abstract::Historically coal mining populations have been reported to have elevated stomach cancer incidence rates. To identify which factors might be associated with cases who reside in these high risk areas, and specifically if particulate exposures from coal mining and coal utilization are associated with risk, a mining area ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850801)56:3<703::aid-cncr28205
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND:Historically, patients with nonmetastatic renal cell carcinoma (RCC) involving adjacent organs have been considered inoperable and incurable. The oncologic efficacy of an aggressive surgical approach was evaluated in a selected subpopulation of RCC patients. Further, an attempt was made to define the clinica...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22629
更新日期:2007-05-15 00:00:00
abstract:BACKGROUND:Over the past 2 decades, significant progress has been made in the field of metastatic colorectal cancer (mCRC) regarding new imaging techniques, surgical interventions, and systemic therapy. It is not known whether the benefit from these interventions has extended overall survival (OS) within the general mC...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28143
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Patients with renal cell carcinoma brain metastases (RCCBM) are frequently excluded from trials and to the authors' knowledge no guidelines currently exist regarding central nervous system (CNS) surveillance or treatment. The objective of the current study was to assist in the creation of treatment guideline...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23769
更新日期:2008-10-01 00:00:00
abstract::Improvement in the management of acute leukemia in adults has not progressed nearly so rapidly as has the treatment of childhood leukemia. One important difference is that most adults have myeloblastic or related forms of the disease (AML), whereas the majority of children have lymphoblastic leukemia (ALL). However, e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197508)36:2+<775::aid-cncr282036
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND:Social needs may affect cancer survivors' health-related quality of life (HRQOL) above and beyond sociodemographic and cancer-related factors. The purpose of this study was to estimate associations between social needs and HRQOL. METHODS:Results included data from 1754 participants in the Detroit Research o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33286
更新日期:2021-02-01 00:00:00
abstract::Fifty-four patients with advanced squamous, large-cell or adeno-carcinoma of the lung were treated with a three drug regimen of high-dose cisplatin, vindesine and a four-day bleomycin infusion (CVB). All patients had measurable disease; none had previously received chemotherapy. Of 52 patients evaluable for response, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830315)51:6<1050::aid-cncr2820
更新日期:1983-03-15 00:00:00
abstract::Two trials of leucovorin (LV) and 5-fluorouracil (5-FU) in patients with metastatic colorectal cancer were done, both using a 3-day loading dose and then weekly doses to minimize toxicity. The first trial used LV administered by intravenous infusion with a constant dose of 5-FU 400 mg/m2, and the second trail used ora...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890315)63:6+<1031::aid-cncr282
更新日期:1989-03-15 00:00:00
abstract::Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870601)59:11<1866::aid-cncr282
更新日期:1987-06-01 00:00:00