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Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field.

Abstract：

BACKGROUND:Single-walled carbon nanotubes (SWNTs) have remarkable physicochemical properties that may have several medical applications. The authors have discovered a novel property of SWNTs-heat release in a radiofrequency (RF) field-that they hypothesized may be used to produce thermal cytotoxicity in malignant cells. METHODS:Functionalized, water-soluble SWNTs were exposed to a noninvasive, 13.56-megahertz RF field, and heating characteristics were measured with infrared thermography. Three human cancer cell lines were incubated with various concentrations of SWNTs and then treated in the RF field. Cytotoxicity was measured by fluorescence-activated cell sorting. Hepatic VX2 tumors in rabbits were injected with SWNTs or with control solutions and were treated in the RF field. Tumors were harvested 48 hours later to assess viability. RESULTS:The RF field induced efficient heating of aqueous suspensions of SWNTs. This phenomenon was used to produce a noninvasive, selective, and SWNT concentration-dependent thermal destruction in vitro of human cancer cells that contained internalized SWNTs. Direct intratumoral injection of SWNTs in vivo followed by immediate RF field treatment was tolerated well by rabbits bearing hepatic VX2 tumors. At 48 hours, all SWNT-treated tumors demonstrated complete necrosis, whereas control tumors that were treated with RF without SWNTs remained completely viable. Tumors that were injected with SWNTs but were not treated with RF also were viable. CONCLUSIONS:The current results suggested that SWNTs targeted to cancer cells may allow noninvasive RF field treatments to produce lethal thermal injury to the malignant cells. Now, the authors are developing SWNTs coupled with cancer cell-targeting agents to enhance SWNT uptake by cancer cells while limiting uptake by normal cells.

journal_name

Cancer

journal_title

Cancer

authors

Gannon CJ,Cherukuri P,Yakobson BI,Cognet L,Kanzius JS,Kittrell C,Weisman RB,Pasquali M,Schmidt HK,Smalley RE,Curley SA

doi

10.1002/cncr.23155

subject

Has Abstract

pub_date

2007-12-15 00:00:00

pages

2654-65

issue

eissn

0008-543X

issn

1097-0142

journal_volume

110

pub_type

杂志文章

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Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field.